Disclosed herein are compounds having the following structure useful as inhibitors of carbonic anhydrase IX (CAIX) and XII, and particularly useful for reducing or eliminating metastases see Formula (I). ##STR00001##

Disclosed herein are compounds having the following structure useful as inhibitors of carbonic anhydrase IX (CAIX) and XII, and particularly useful for reducing or eliminating metastases see Formula (I). ##STR00001##

The present disclosure relates to compounds that are capable of inhibiting PRMT8 and/or upregulating SirT1. The disclosure further relates to methods of treating neurodegenerative diseases and disorders (e.g., Alzheimer's disease).

The present disclosure relates to compounds that are capable of inhibiting PRMT8 and/or upregulating SirT1. The disclosure further relates to methods of treating neurodegenerative diseases and disorders (e.g., Alzheimer's disease).

The present disclosure relates to compounds, pharmaceutical compositions comprising such compounds, and use of such compounds in methods of treatment or in medicaments for treatment of inflammatory diseases and certain neurological disorders that are related to inflammatory signaling processes, including but not limited to misfolded proteins.

##STR00001##

A composite amine absorbent to absorb at least one of CO.sub.2 and H.sub.2S in a gas includes: a chain monoamine; a diamine; a cyclic compound represented by the following chemical formula:

##STR00001##

where R.sup.1: any one of hydrogen, a hydrocarbon group having a carbon number of 1 to 4, and a hydroxyalkyl group, R.sup.2: oxygen or NR.sup.3, and R.sup.3: any one of hydrogen, a hydrocarbon group having a carbon number of 1 to 4, and a hydroxyalkyl group; and water.

A compound of Formula I: ##STR00001##
or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of Formula (I) as selective inhibitors of indoleamine 2,3-dioxygenase. The invention also relates to the use of the compounds of Formula (I) for the treatment or prevention of diseases cancer, infections, central nervous system disease or disorder, and immune-related disorders, either as a single agent or in combination with other therapies.

A compound of Formula I: ##STR00001##
or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of Formula (I) as selective inhibitors of indoleamine 2,3-dioxygenase. The invention also relates to the use of the compounds of Formula (I) for the treatment or prevention of diseases cancer, infections, central nervous system disease or disorder, and immune-related disorders, either as a single agent or in combination with other therapies.

The invention relates to a compound of formula (I), wherein: A1 and A.sub.2 represent, independently of one another, a binding group comprising at least one nitrogen atom; Q.sub.1 and Q.sub.2 represent, independently of one another, a linkage group; and x is an integer between 2 and 6, preferably between 3 and 6. The invention also relates to a rubber composition comprising said compound.

The invention relates to a compound of formula (I), wherein: A1 and A.sub.2 represent, independently of one another, a binding group comprising at least one nitrogen atom; Q.sub.1 and Q.sub.2 represent, independently of one another, a linkage group; and x is an integer between 2 and 6, preferably between 3 and 6. The invention also relates to a rubber composition comprising said compound.