C07D239/10

PROCESS TO PREPARE PROPYLENE AMINES AND PROPYLENE AMINE DERIVATIVES

A process is provided to prepare propylene amines of the formula NH.sub.2(ANH).sub.pR, wherein R is a hydrogen atom or an alkyl group, p is at least 1 when R is an alkyl group, and at least 2 when R is a hydrogen atom, or derivatives or precursors thereof wherein one or more units NHANH may be present as a cyclic urea unit

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or a cyclic unit

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or between two units NHANH a carbonyl bond is present, each unit A can be independently an alkylene unit and at least one unit A is a C.sub.3H.sub.6 unit, wherein each C.sub.3H.sub.6 unit can be linear or branched. The process includes reacting (i) at least one of a hydroxy-functional compound chosen from the alkanolamine-functional compounds, and dihydroxyalkylene compounds, with (ii) an amine-functional compound, in the presence of (iii) a carbon oxide delivering agent, wherein at least one of the alkanolamine-functional compound, the amine-functional compound and/or the carbon oxide delivering agent contains at least one alkylene unit (A) that is a propylene unit

NADPH Oxidase Inhibitors and Uses Thereof

This disclosure relates to compounds and methods of treating or preventing a Nox related disease or condition comprising administering to a subject in need thereof a Nox inhibitor or pharmaceutical compositions comprising a Nox inhibitor disclosed herein, derivatives, or compounds disclosed herein optionally substituted with one or more substitutes including optional salt and prodrug forms. In certain embodiments, this disclosure relates to sulfonylurea compounds and uses reported herein.

SUBSTITUTED N-PHENYLURACILS AND SALTS THEREOF, AND USE THEREOF AS HERBICIDAL ACTIVE SUBSTANCES

Substituted N-phenyluracils and salts thereof and use thereof as herbicidal agents.

The present invention relates to substituted N-phenyluracils of the general formula (I) or salts thereof,

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where the radicals in the general formula (I) conform to the definitions given in the description, and to the use thereof as herbicides, especially for control of broad-leaved weeds and/or weed grasses in crops of useful plants and/or as plant growth regulators for influencing the growth of crops of useful plants.

SUBSTITUTED N-PHENYLURACILS AND SALTS THEREOF, AND USE THEREOF AS HERBICIDAL ACTIVE SUBSTANCES

Substituted N-phenyluracils and salts thereof and use thereof as herbicidal agents.

The present invention relates to substituted N-phenyluracils of the general formula (I) or salts thereof,

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where the radicals in the general formula (I) conform to the definitions given in the description, and to the use thereof as herbicides, especially for control of broad-leaved weeds and/or weed grasses in crops of useful plants and/or as plant growth regulators for influencing the growth of crops of useful plants.

PROCESS FOR PREPARATION OF MAVACAMTEN AND SOLID STATE FORMS THEREOF

The present application relates to process for preparation of Mavacamten, preparative methods of various crystalline forms of Mavacamten and amorphous form of Mavacamten, its preparative method, and pharmaceutical compositions thereof. The present application also relates to solid dispersions of Mavacamten, their preparative methods and pharmaceutical compositions containing solid dispersions of Mavacamten.

PROCESS FOR PREPARATION OF MAVACAMTEN AND SOLID STATE FORMS THEREOF

The present application relates to process for preparation of Mavacamten, preparative methods of various crystalline forms of Mavacamten and amorphous form of Mavacamten, its preparative method, and pharmaceutical compositions thereof. The present application also relates to solid dispersions of Mavacamten, their preparative methods and pharmaceutical compositions containing solid dispersions of Mavacamten.

Luminescent janus-type, two-coordinated metal complexes

The co-linear or near co-linear structure of bimetallic Janus-type two-coordinated metal complexes may allow for a large transition dipole moment that can enhance the radiative lifetime. The symmetric nature of the bimetallic Janus complexes diminishes or eliminates the polar nature of the monometallic carbene-metal-amide/arene complexes.

Luminescent janus-type, two-coordinated metal complexes

The co-linear or near co-linear structure of bimetallic Janus-type two-coordinated metal complexes may allow for a large transition dipole moment that can enhance the radiative lifetime. The symmetric nature of the bimetallic Janus complexes diminishes or eliminates the polar nature of the monometallic carbene-metal-amide/arene complexes.

URACIL COMPOUND CONTAINING CARBOXYLATE FRAGMENT, PREPARATION METHOD THEREFOR, AND HERBICIDAL COMPOSITION AND USE THEREOF

A uracil compound containing a carboxylate fragment, a preparation method therefor, and a herbicidal composition and use thereof are provided. The preparation method includes a contact reaction between a carboxylic acid compound and different substituted alcohol, halogenated, or sulfonate compound in a presence of a solvent. The uracil compound containing a carboxylate fragment provided by the present invention has better herbicidal activity compared with the prior art.

URACIL COMPOUND CONTAINING CARBOXYLATE FRAGMENT, PREPARATION METHOD THEREFOR, AND HERBICIDAL COMPOSITION AND USE THEREOF

A uracil compound containing a carboxylate fragment, a preparation method therefor, and a herbicidal composition and use thereof are provided. The preparation method includes a contact reaction between a carboxylic acid compound and different substituted alcohol, halogenated, or sulfonate compound in a presence of a solvent. The uracil compound containing a carboxylate fragment provided by the present invention has better herbicidal activity compared with the prior art.