An isoxazoline compound, a preparation method therefor and an application thereof. The compound has a structured as represented by general formula I. Also provided is use of the compound represented by general formula I as an insecticide and acaricide as well as an animal parasite control agent.

##STR00001##

Disclosed are an isoxazoline compound and an application thereof. The structure of the compound is as shown in general formula (I). The definitions of substituents in the formula are described in the description. The description also discloses use of the compound of general formula (I) as an insecticide, acaricide and animal parasite control agent.

##STR00001##

An isoxazolin-5-one derivative represented by formula (1) below:

##STR00001## wherein R.sup.1 represents a C1-C6 haloalkyl group, Q represents a C3-C8 cycloalkyl group substituted with a C1-C6 alkoxy group, each of R.sup.2, R.sup.3 and X represents a certain substituent or the like, and n represents an integer of 1 to 4, wherein X's may be different from each other when n represents an integer of 2 to 4, and a herbicide containing the isoxazolin-5-one derivative as an active ingredient are provided.

An isoxazolin-5-one derivative represented by formula (1) below:

##STR00001## wherein R.sup.1 represents a C1-C6 haloalkyl group, Q represents a C3-C8 cycloalkyl group substituted with a C1-C6 alkoxy group, each of R.sup.2, R.sup.3 and X represents a certain substituent or the like, and n represents an integer of 1 to 4, wherein X's may be different from each other when n represents an integer of 2 to 4, and a herbicide containing the isoxazolin-5-one derivative as an active ingredient are provided.

The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.

##STR00001##

The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.

##STR00001##

12(S)-hydroxyeicosatrienoic acid (12(S)-HETrE) compounds and compositions comprising the same are disclosed. Methods of using the compounds in the prevention and treatment of thrombosis and thrombotic disorders are also disclosed.

An isoxazolin-5-one derivative represented by the following (1): ##STR00001##
wherein R.sup.1 represents a C1-C6 haloalkyl group, and R.sup.2 to R.sup.4 and X each represents a certain substituent or the like; and n represents an integer of 1 to 4, wherein X's may be different from each other when n represents an integer of 2 to 4, and an herbicide containing the isoxazolin-5-one derivative as an active ingredient are provided.

An isoxazolin-5-one derivative represented by the following (1): ##STR00001##
wherein R.sup.1 represents a C1-C6 haloalkyl group, and R.sup.2 to R.sup.4 and X each represents a certain substituent or the like; and n represents an integer of 1 to 4, wherein X's may be different from each other when n represents an integer of 2 to 4, and an herbicide containing the isoxazolin-5-one derivative as an active ingredient are provided.

The invention provides compounds that inhibit FTO (fat mass and obesity), including pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof, particularly obesity, with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.