Patent classifications
C
CHEMISTRY; METALLURGY
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C07
ORGANIC CHEMISTRY
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C07D
HETEROCYCLIC COMPOUNDS
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263/00
Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
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C07D263/02
not condensed with other rings
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C07D263/08
having one double bond between ring members or between a ring member and a non-ring member
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C07D263/16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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C07D263/18

NEPRILYSIN INHIBITORS
20170020904 · 2017-01-26 · ·

In one aspect, the invention relates to compounds having the formula:

##STR00001##

where R.sup.1-R.sup.6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.