Patent classifications
C
CHEMISTRY; METALLURGY
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C07
ORGANIC CHEMISTRY
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C07D
HETEROCYCLIC COMPOUNDS
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263/00
Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
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C07D263/02
not condensed with other rings
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C07D263/08
having one double bond between ring members or between a ring member and a non-ring member
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C07D263/16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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C07D263/28
Nitrogen atoms not forming part of a nitro radical
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C07D263/28

Dihydrooxazole and thiourea derivatives modulating the NLRP3 inflammasome pathway
12624010 · 2026-05-12 · ·

The present invention relates to novel compounds for the treatment, alleviation or prevention of a group of diseases, disorders and abnormalities which are responsive to the modulation or inhibition of the activation of a component of the NLRP3 inflammasome pathway. In particular, the component of the inflammasome pathway is a NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome. More particularly, the compounds of the present invention have the capability to modulate the NLRP3 inflammasome pathway. Further, the compounds of the present invention are suitable for the treatment, alleviation or prevention of a group of diseases, disorders and abnormalities which are responsive to the modulation, in particular decrease, IL-1 beta and/or IL-18 levels.