Provided herein are compounds and compositions thereof for modulating bis-phosphoglycerate mutase (BPGM) for treating sickle cell disease.

The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

The present invention provides a compound represented by formula (I) [wherein L represents an oxygen atom or CH.sub.2, E represents a C2-C10 chain hydrocarbon group or the like, R.sup.1 represents a C1-C3 chain hydrocarbon group or the like, R.sup.2 represents a C1-C3 chain hydrocarbon group or the like, and n is 0, 1, 2 or 3.] or its N oxide or agriculturally acceptable salt, which is a compound that have excellent pests controlling effects.

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The present invention provides a compound represented by formula (I) [wherein L represents an oxygen atom or CH.sub.2, E represents a C2-C10 chain hydrocarbon group or the like, R.sup.1 represents a C1-C3 chain hydrocarbon group or the like, R.sup.2 represents a C1-C3 chain hydrocarbon group or the like, and n is 0, 1, 2 or 3.] or its N oxide or agriculturally acceptable salt, which is a compound that have excellent pests controlling effects.

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The invention relates to resorcinol-based compounds of formula (I), to the salts, solvates, optical and/or geometrical isomers thereof, to the use thereof as active agents for depigmenting, lightening and/or bleaching keratin materials, and/or for preventing, reducing and/or treating impairment of the skin complexion or of the colour of the semi-mucous membranes. The invention also relates to a non-therapeutic cosmetic treatment process for depigmenting, lightening and/or bleaching keratin materials, and/or for preventing, reducing and/or treating impairment of the skin complexion or the colour of the semi-mucous membranes. ##STR00001##

The invention relates to resorcinol-based compounds of formula (I), to the salts, solvates, optical and/or geometrical isomers thereof, to the use thereof as active agents for depigmenting, lightening and/or bleaching keratin materials, and/or for preventing, reducing and/or treating impairment of the skin complexion or of the colour of the semi-mucous membranes. The invention also relates to a non-therapeutic cosmetic treatment process for depigmenting, lightening and/or bleaching keratin materials, and/or for preventing, reducing and/or treating impairment of the skin complexion or the colour of the semi-mucous membranes. ##STR00001##

A method of modulating ribonucleotide reductase activity in a neoplastic cell includes administering to the cell an amount of an oxadiazole, thiazole, diazole, triazole, or tetrazole ribonucleotide reductase modulator (RRmod), the amount being effective to inhibit neoplastic cell growth.

Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.

There is herein provided a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the ring containing Q.sup.1 to Q.sup.5, and the groups R.sup.1, R.sup.2 and R.sup.3, have meanings as provided in the description. ##STR00001##