This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's Disease, familial Alzheimer's Disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.

Provided are a labelling agent including a compound of the following Formula 1, a labelling composition, a method of labelling a protein with the labelling agent, and a method of detecting the protein using the labelling agent: ##STR00001##
wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, and R.sub.8 are independently H, substituted or unsubstituted —C.sub.1-10-alkyl-, —C.sub.2-10-alkenyl, or —C.sub.2-10-alkynyl, R.sub.7 is H or —NR.sub.9R.sub.10, R.sub.9 and R.sub.10 are independently H, substituted or unsubstituted —C.sub.1-10-alkyl-, —C.sub.2-10-alkenyl, or —C.sub.2-10-alkynyl, X is —NR.sub.11, —O, or S, R.sub.11 is H, substituted or unsubstituted —C.sub.1-10-alkyl-, —C.sub.2-10-alkenyl, or —C.sub.2-10-alkynyl, Y is —OR.sub.12 or —NR.sub.13R.sub.14, R.sub.12 is H, substituted or unsubstituted —C.sub.1-10-alkyl-, —C.sub.2-10-alkenyl, or —C.sub.2-10-alkynyl, and R.sub.13 and R.sub.14 are independently H, substituted or unsubstituted —C.sub.1-10-alkyl-, —C.sub.2-10-alkenyl, or —C.sub.2-10-alkynyl.

Provided are a labelling agent including a compound of the following Formula 1, a labelling composition, a method of labelling a protein with the labelling agent, and a method of detecting the protein using the labelling agent: ##STR00001##
wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, and R.sub.8 are independently H, substituted or unsubstituted —C.sub.1-10-alkyl-, —C.sub.2-10-alkenyl, or —C.sub.2-10-alkynyl, R.sub.7 is H or —NR.sub.9R.sub.10, R.sub.9 and R.sub.10 are independently H, substituted or unsubstituted —C.sub.1-10-alkyl-, —C.sub.2-10-alkenyl, or —C.sub.2-10-alkynyl, X is —NR.sub.11, —O, or S, R.sub.11 is H, substituted or unsubstituted —C.sub.1-10-alkyl-, —C.sub.2-10-alkenyl, or —C.sub.2-10-alkynyl, Y is —OR.sub.12 or —NR.sub.13R.sub.14, R.sub.12 is H, substituted or unsubstituted —C.sub.1-10-alkyl-, —C.sub.2-10-alkenyl, or —C.sub.2-10-alkynyl, and R.sub.13 and R.sub.14 are independently H, substituted or unsubstituted —C.sub.1-10-alkyl-, —C.sub.2-10-alkenyl, or —C.sub.2-10-alkynyl.

The present invention provides a polymerizable compound that reduces, for example, the likelihood of crystals precipitating in a polymerizable composition including the polymerizable compound and enables the polymerizable composition to have high preservation stability and a polymerizable composition including the polymerizable compound which reduces the likelihood of inconsistencies being formed in a film-like polymer produced by polymerizing the polymerizable composition. Also provided are a polymer-produced by polymerizing the polymerizable composition and an optically anisotropic body including the polymer. The present invention provides the compound represented by General Formula (I), a composition including the compound, a polymer produced by polymerizing the composition, and an optically anisotropic body including the polymer.

The present invention provides a polymerizable compound that reduces, for example, the likelihood of crystals precipitating in a polymerizable composition including the polymerizable compound and enables the polymerizable composition to have high preservation stability and a polymerizable composition including the polymerizable compound which reduces the likelihood of inconsistencies being formed in a film-like polymer produced by polymerizing the polymerizable composition. Also provided are a polymer-produced by polymerizing the polymerizable composition and an optically anisotropic body including the polymer. The present invention provides the compound represented by General Formula (I), a composition including the compound, a polymer produced by polymerizing the composition, and an optically anisotropic body including the polymer.

Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use. ##STR00001##

Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use. ##STR00001##

Novel 2-substituted glutamylanides useful as modulators of ASCT2 inhibitors. Compounds of the present invention can be used to treat patients suffering from diseases caused or influenced by abnormal ASCT2 transporter dysfunction.

Novel 2-substituted glutamylanides useful as modulators of ASCT2 inhibitors. Compounds of the present invention can be used to treat patients suffering from diseases caused or influenced by abnormal ASCT2 transporter dysfunction.

The present invention relates to compounds that have ultraviolet light absorbing properties, and which can also have mesogenic properties. The present invention also relates to compositions that include one or more such compounds, and to articles of manufacture that include one or more such compounds, such as optical elements that include an optical substrate and a layer that includes at least one compound of the present invention.