The disclosure provides a system for production of reactive intermediates from lignocellulosic biomass. The reactive intermediates can be used as platform chemicals for biological conversions or can be further catalytically upgraded to be used as drop in reagents for fuels. The disclosure provides methods and compositions useful for processing biomass to biofuels and intermediates.

A salt of a quinazoline derivative (N-[4-(3-chlorine-4-fluoroanilino)]-7-(3-morpholinepropanol)-6-(2-fluoroacrylamide)-quinazoline, the structure thereof is as represented by formula I). Compared with a known quinazoline derivative, the salt of the quinazoline derivative has one or more improved properties and at least has better water solubility, wherein a citrate, a benzene sulfonate, and an ethanedisulphonate thereof further have better crystallinity and are not easy to absorb moisture. ##STR00001##

A salt of a quinazoline derivative (N-[4-(3-chlorine-4-fluoroanilino)]-7-(3-morpholinepropanol)-6-(2-fluoroacrylamide)-quinazoline, the structure thereof is as represented by formula I). Compared with a known quinazoline derivative, the salt of the quinazoline derivative has one or more improved properties and at least has better water solubility, wherein a citrate, a benzene sulfonate, and an ethanedisulphonate thereof further have better crystallinity and are not easy to absorb moisture. ##STR00001##

A method for preparing a metal-impregnated, carbon-supported catalyst composition is provided. The method comprises providing a carbon support particle having a smallest dimension of greater than 0.5 millimeters; contacting the carbon support particle with a basic aqueous impregnation solution comprising abase having a pK.sub.b of at most 9 and at least one first metal-containing compound, wherein the first metal-containing compound comprises at least one first metal selected from groups 8, 9 and 10 of the periodic table, to form a first metal-impregnated carbon support particle; and drying the first metal-impregnated carbon support particle.

A method for preparing a metal-impregnated, carbon-supported catalyst composition is provided. The method comprises providing a carbon support particle having a smallest dimension of greater than 0.5 millimeters; contacting the carbon support particle with a basic aqueous impregnation solution comprising abase having a pK.sub.b of at most 9 and at least one first metal-containing compound, wherein the first metal-containing compound comprises at least one first metal selected from groups 8, 9 and 10 of the periodic table, to form a first metal-impregnated carbon support particle; and drying the first metal-impregnated carbon support particle.

A method for preparing a metal-impregnated, carbon-supported catalyst composition is provided. The method comprises providing a carbon support particle having a smallest dimension of greater than 0.5 millimeters; contacting the carbon support particle with an organic impregnation solution comprising an organic solvent and at least one first metal-containing compound, wherein the first metal-containing compound comprises at least one first metal selected from groups 8, 9 and 10 of the periodic table, to form a first metal-impregnated carbon support particle; and drying the first metal-impregnated carbon support particle.

A method for preparing a metal-impregnated, carbon-supported catalyst composition is provided. The method comprises providing a carbon support particle having a smallest dimension of greater than 0.5 millimeters; contacting the carbon support particle with an organic impregnation solution comprising an organic solvent and at least one first metal-containing compound, wherein the first metal-containing compound comprises at least one first metal selected from groups 8, 9 and 10 of the periodic table, to form a first metal-impregnated carbon support particle; and drying the first metal-impregnated carbon support particle.

A method for separating a mixture of materials A and B by extractive distillation, using an extraction medium having a higher affinity to B than to A, collecting a liquid fraction on a collecting tray and heated and partially evaporated in a first indirect heat exchanger, collecting the resultant vapor is released into the column and a non-evaporated proportion of the liquid fraction in the sump of the column, and a series of heating, separation and cooling where partially cooled extraction medium fraction is used as heating medium for a heat exchanger.

A method for separating a mixture of materials A and B by extractive distillation, using an extraction medium having a higher affinity to B than to A, collecting a liquid fraction on a collecting tray and heated and partially evaporated in a first indirect heat exchanger, collecting the resultant vapor is released into the column and a non-evaporated proportion of the liquid fraction in the sump of the column, and a series of heating, separation and cooling where partially cooled extraction medium fraction is used as heating medium for a heat exchanger.

Disclosed are integrated systems and methods for the conversion of epoxides to beta lactones and to multiple C.sub.3 products and/or C.sub.4 products.