The present invention provides a compound represented by formula (I) or a pharmaceutically acceptable salt thereof which has the effect of antagonizing the LPA1 receptor.

An object of the present invention is to provide a lactone compound having excellent radical trapping performance.

Provided is a lactone compound represented by Formula (I).

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L represents a linking group represented by Formula (L1) or Formula (L2).

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The present invention relates to the field of organic synthesis and, more specifically, it concerns a process for preparing compound of formula (I) by a hydroboration-oxidation reaction of compound of formula (II).

The present invention relates to the field of organic synthesis and, more specifically, it concerns a process for preparing compound of formula (I) by a hydroboration-oxidation reaction of compound of formula (II).

Disclosed herein are embodiments of a method for making substituted compounds with specific and selectable regiochemistry. Also disclosed are compounds made by the method. The method may comprise contacting a compound having a formula I

##STR00001##

with a compound according to formula II

##STR00002##

in the presence of a Lewis acid to form a phenol compound according to formula III and/or a benzofuranone compound according to formula IV

##STR00003##

Disclosed herein are embodiments of a method for making substituted compounds with specific and selectable regiochemistry. Also disclosed are compounds made by the method. The method may comprise contacting a compound having a formula I

##STR00001##

with a compound according to formula II

##STR00002##

in the presence of a Lewis acid to form a phenol compound according to formula III and/or a benzofuranone compound according to formula IV

##STR00003##

##STR00001##

A method for preparing a compound of Formula (1) and compounds therefrom, comprising treating a compound of Formula (2) to provide a compound of Formula (5) and treating the compound of Formula (5) with a hydroxylamine salt wherein R.sup.1, R.sup.2 and m are as defined in the specification. The compound of Formula (1), prepared by the above method, can be used to prepare a compound of Formula (8) wherein R.sup.1, R.sup.2, R.sup.3 and m are as defined in the specification.

The compound (A) is represented by formula (1).

R.sub.1O—R.sub.2—OR.sub.1   (1)

(In formula (1), each R.sub.1 independently represents a group represented by formula (2), or a hydrogen atom, and R.sub.2 represents a linear or branched alkylene group having 1 to 16 carbon atoms, or a linear or branched alkenylene group having 2 to 16 carbon atoms, provided that at least one R.sub.1 is a group represented by formula (2).)

##STR00001##

(In formula (2), -* represents a bonding hand.)

The compound (A) is represented by formula (1).

R.sub.1O—R.sub.2—OR.sub.1   (1)

(In formula (1), each R.sub.1 independently represents a group represented by formula (2), or a hydrogen atom, and R.sub.2 represents a linear or branched alkylene group having 1 to 16 carbon atoms, or a linear or branched alkenylene group having 2 to 16 carbon atoms, provided that at least one R.sub.1 is a group represented by formula (2).)

##STR00001##

(In formula (2), -* represents a bonding hand.)

An object of the present invention is to provide a lactone compound having excellent water stability.

Provided is a lactone compound represented by Formula (I).

##STR00001##

In Formula (I), R.sup.1 and R.sup.2 each independently represent a substituent which does not have a dissociative proton and has a Hammett's substituent constant σp value of −0.90 or more and −0.03 or less. R.sup.3 represents a substituent which does not have a dissociative proton and has a Hammett's substituent constant σp value of −0.90 or more and −0.03 or less, or a hydrogen atom. Y represents a substituent and n represents an integer of 1 to 4. In a case where n is an integer of 2 to 4, a plurality of Y's may be the same substituent or substituents different from each other.