The present invention relates to a process for preparing sordidin, comprising a step of preparing 4-(2-ethyl-1,3-dioxolan-2-yl)pentan-2-one by means of a reaction in which 2-ethyl-2-(pent-4-en-2-yl)-1,3-dioxolane is oxidized in the presence of a catalyst chosen from the group comprising organometallic complexes of transition metals.

The present invention relates to a process for preparing sordidin, comprising a step of preparing 4-(2-ethyl-1,3-dioxolan-2-yl)pentan-2-one by means of a reaction in which 2-ethyl-2-(pent-4-en-2-yl)-1,3-dioxolane is oxidized in the presence of a catalyst chosen from the group comprising organometallic complexes of transition metals.

Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid of Formula (I), and methods for making such non-natural amino acids and polypeptides.

Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid of Formula (I), and methods for making such non-natural amino acids and polypeptides.

The coupling of aryl, heteroaryl, and vinyl halides with ,-difluoroketones or silyl ethers or siylenol ethers of ,-difluoroketones and ,-difluoroamides and esters are described. Further derivatization of the coupling products (such as ketone cleavage and Baeyer-Villiger oxidation) is also described.

The coupling of aryl, heteroaryl, and vinyl halides with ,-difluoroketones or silyl ethers or siylenol ethers of ,-difluoroketones and ,-difluoroamides and esters are described. Further derivatization of the coupling products (such as ketone cleavage and Baeyer-Villiger oxidation) is also described.

Novel molecules and novel fragrance molecules are disclosed, with the series of related molecules all containing a cyclic acetal or dioxepane sub-structure in combination with a carbonyl sub-structure and a cyclic structure which may be a phenyl or non-phenyl substituent. The molecules may contain further substitutions or modifications. The molecules compose or modify the sensory qualities of a fragrance, flavor, or a scented or flavored product. Further information is given on the predicted olfactory receptor activity of the invention and a method for composing novel molecular structures with regard to particular receptors of interest in order to improve the pleasantness, multidimensionality, and utility of olfactory molecules.

Novel molecules and novel fragrance molecules are disclosed, with the series of related molecules all containing a cyclic acetal or dioxepane sub-structure in combination with a carbonyl sub-structure and a cyclic structure which may be a phenyl or non-phenyl substituent. The molecules may contain further substitutions or modifications. The molecules compose or modify the sensory qualities of a fragrance, flavor, or a scented or flavored product. Further information is given on the predicted olfactory receptor activity of the invention and a method for composing novel molecular structures with regard to particular receptors of interest in order to improve the pleasantness, multidimensionality, and utility of olfactory molecules.

To provide an industrial method for producing a substituted benzoic acid compound useful as an intermediate of pharmaceutical and agricultural chemicals with high purity and high yield. A compound represented by the formula (II): ##STR00001##
(wherein Q is a 5- or 6-membered saturated heterocyclic group (the heterocyclic group may be substituted by alkyl) containing one or two of at least one type of hetero atom selected from the group consisting of an oxygen atom and a sulfur atom, or dialkoxymethyl, T is trifluoromethyl, nitro, cyano, SOA.sup.1, SO.sub.2A.sup.1, PO(OA.sup.1)(OA.sup.2), COA.sup.1, CO.sub.2A.sup.1 or CONA.sup.1A.sup.2, each of A.sup.1 and A.sup.2 which are independent of each other, is a hydrogen atom, alkyl or haloalkyl, X is halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, dialkylaminosulfonyl, di(haloalkyl)aminosulfonyl, nitro or cyano, Y is a chlorine atom, a bromine atom or an iodine atom, and n is an integer of from 1 to 6), carbon monoxide and a compound represented by the formula ROH (wherein R is alkyl) are reacted, followed by hydrolysis to obtain a compound represented by the formula (I): ##STR00002##
wherein Q, T, X and n are as defined above.

To provide an industrial method for producing a substituted benzoic acid compound useful as an intermediate of pharmaceutical and agricultural chemicals with high purity and high yield. A compound represented by the formula (II): ##STR00001##
(wherein Q is a 5- or 6-membered saturated heterocyclic group (the heterocyclic group may be substituted by alkyl) containing one or two of at least one type of hetero atom selected from the group consisting of an oxygen atom and a sulfur atom, or dialkoxymethyl, T is trifluoromethyl, nitro, cyano, SOA.sup.1, SO.sub.2A.sup.1, PO(OA.sup.1)(OA.sup.2), COA.sup.1, CO.sub.2A.sup.1 or CONA.sup.1A.sup.2, each of A.sup.1 and A.sup.2 which are independent of each other, is a hydrogen atom, alkyl or haloalkyl, X is halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, dialkylaminosulfonyl, di(haloalkyl)aminosulfonyl, nitro or cyano, Y is a chlorine atom, a bromine atom or an iodine atom, and n is an integer of from 1 to 6), carbon monoxide and a compound represented by the formula ROH (wherein R is alkyl) are reacted, followed by hydrolysis to obtain a compound represented by the formula (I): ##STR00002##
wherein Q, T, X and n are as defined above.