The present invention relates to prevention of congenital deformations. The invention further relates to cancer inhibition and prevention. The invention further relates to methods and compositions to modulate, antagonize, or agonize disparate signaling pathways that may converge to regulate patterning events and gene expression during prenatal development, post-natal development, and during development in the adult organism. The invention also relates to activators or deactivators of pyruvate kinase M2 (PKM2) for the treatment, prevention, or amelioration of diseases related to PKM2 function.

Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.

Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.

The present disclosure relates to a preparation method of a porous super absorbent polymer exhibiting excellent absorption performance and improved absorption rate due to a novel pore structure, and a porous super absorbent polymer prepared therefrom. The porous super absorbent polymer includes a base resin powder including a cross-linked polymer of a water soluble ethylene-based unsaturated monomer containing acidic groups which are at least partially neutralized, and an inorganic filler contained in the cross-linked structure of the cross-linked polymer, wherein the base resin powder includes a plurality of pores having a diameter of a sub-micron (sub-m) scale in the cross-linked structure, and an interconnected pore structure in the form of an open channel in which 90% or more of the pores are connected to each other.

The present disclosure relates to a preparation method of a porous super absorbent polymer exhibiting excellent absorption performance and improved absorption rate due to a novel pore structure, and a porous super absorbent polymer prepared therefrom. The porous super absorbent polymer includes a base resin powder including a cross-linked polymer of a water soluble ethylene-based unsaturated monomer containing acidic groups which are at least partially neutralized, and an inorganic filler contained in the cross-linked structure of the cross-linked polymer, wherein the base resin powder includes a plurality of pores having a diameter of a sub-micron (sub-m) scale in the cross-linked structure, and an interconnected pore structure in the form of an open channel in which 90% or more of the pores are connected to each other.

Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.

Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.

An electrolyte and an electrochemical device, which relates to the field of energy storage materials. The electrolyte includes an additive A, an additive B and an additive C, the additive A selected from a group consisting of multi-cyano six-membered N-heterocyclic compounds represented by Formula I-1, Formula I-2 or Formula I-3, and combinations thereof, the additive B is at least one sulfonate compound, and the additive C is at least one halogenated cyclic carbonate compound. The electrochemical device includes the above electrolyte. The electrolyte of the present disclosure can effectively passivate the surface activity of the positive electrode material, inhibit the oxidation of the electrolyte, and effectively reduce gas production of a battery, meanwhile the electrolyte can be also adsorbed catalytically active of the graphite surface to form a more stable SEI film, thereby effectively reducing side reactions ##STR00001##

An electrolyte and an electrochemical device, which relates to the field of energy storage materials. The electrolyte includes an additive A, an additive B and an additive C, the additive A selected from a group consisting of multi-cyano six-membered N-heterocyclic compounds represented by Formula I-1, Formula I-2 or Formula I-3, and combinations thereof, the additive B is at least one sulfonate compound, and the additive C is at least one halogenated cyclic carbonate compound. The electrochemical device includes the above electrolyte. The electrolyte of the present disclosure can effectively passivate the surface activity of the positive electrode material, inhibit the oxidation of the electrolyte, and effectively reduce gas production of a battery, meanwhile the electrolyte can be also adsorbed catalytically active of the graphite surface to form a more stable SEI film, thereby effectively reducing side reactions ##STR00001##

The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.