The disclosure relates to compounds that are, e.g., PAP Associated Domain Containing 5 (PAPD5) inhibitors and methods of use thereof.

The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway

##STR00001##

wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.

The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway

##STR00001##

wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.

There is provided compounds of formula (I), or pharmaceutically-acceptable salts thereof, wherein R.sup.1 to R.sup.4 and X.sup.1 to X.sup.5 have meanings provided in the description, which compounds are useful in the treatment of cancers.

##STR00001##

There is provided compounds of formula (I), or pharmaceutically-acceptable salts thereof, wherein R.sup.1 to R.sup.4 and X.sup.1 to X.sup.5 have meanings provided in the description, which compounds are useful in the treatment of cancers.

##STR00001##

Compounds of the formula (I)

##STR00001## wherein the substituents are as defined in claim 1, useful as a pesticides, especially as fungicides.

Compounds of the formula (I)

##STR00001## wherein the substituents are as defined in claim 1, useful as a pesticides, especially as fungicides.

The present invention provides PI3K protein kinase modulators of Formula (I) ##STR00001##
wherein R, n, R.sup.1, R.sup.2, L.sup.1, Cy.sup.1 and Cy.sup.2 are as defined herein, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

The present invention provides PI3K protein kinase modulators of Formula (I) ##STR00001##
wherein R, n, R.sup.1, R.sup.2, L.sup.1, Cy.sup.1 and Cy.sup.2 are as defined herein, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

The present disclosure is concerned with xanthine analogs, methods of making xanthine analogs, and methods of treating West Nile virus using these analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.