Methods for treating hypertension and associated systems and methods are disclosed herein. One aspect of the present technology, for example, is directed to methods for therapeutic renal neuromodulation that partially inhibit sympathetic neural activity in renal nerves proximate a renal blood vessel of a human patient having a 24-hour heart rate at or above a median heart rate for a population of hypertensive patients. This reduction in sympathetic neural activity is expected to therapeutically treat one or more conditions associated with hypertension of the patient. Renal sympathetic nerve activity can be modulated, for example, using an intravascularly positioned catheter carrying a neuromodulation assembly, e.g., a neuromodulation assembly configured to use electrically-induced, thermally-induced, and/or chemically-induced approaches to modulate the renal nerves.

Provided herein are catheter devices, systems, and methods to ablate a tissue location. The devises, systems, and methods disclosed herein include ablation systems including a catheter system with inner and outer shafts that deliver an ablation medium (e.g., a cryogenic ablation medium) to a body lumen and evacuate the ablation medium from the body lumen. In some embodiments, devices, systems, and methods disclose herein include expandable structures that facilitate in positioning of nozzles and/or evacuation of ablation medium from a body lumen.

Temperature sensing catheters and systems that can be used during cardiac ablation procedures to measure and monitor temperatures, and the rate and spread of temperature changes in the heart. The temperature data can be used to calculate temperature gradients, which may be used to estimate if and when certain regions of heart may undergo injury due to thermal exposure. The temperature data can be used to limit or cut-off power delivery to an ablation catheter, or otherwise modify the ablation procedure, to prevent injury to certain regions of heart. In some cases, the temperature data is used to control aspects of the ablation in a feedback loop control scheme.

A non-invasive and permeable RF diagnosis and treatment equipment and its catheter are provided. The catheter which comprises a tube body, a RF electrode array and a flexible protecting net has a retractable cavity, and the RF electrode array is attached to an outer surface of the retractable cavity; the flexible protecting net surrounding outside of the RF electrode array has a connector connected with the tube body and multiple holes. The retractable cavity has a smaller volume contraction state and a larger volume expansion state. Using the catheter, when inserting or pulling out the catheter, the RF electrode array will not contact the inner wall of the organ, but the flexible protecting net contacts the inner wall of the organ. In this way, the scratch of the inner wall of the organ caused by the RF electrode array can be minimized or even avoided through the flexible protecting net.

An intravascular ablation device, including a flexible elongate body; an expandable element positioned on the elongate body; a radiofrequency or electroporation treatment segment located distally of the expandable element; a cryogenic coolant source in fluid communication with an interior of the expandable element; and a radiofrequency or electroporation energy source in communication with the radiofrequency or electroporation treatment segment.

A device for therapeutic neuromodulation in a nasal region can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

A cryoablation system is provided that can assume a directional activated state and includes a cryoablation probe and a controller. The cryoablation probe has an active region that includes a cooling compartment and an opposing heating compartment that are thermally insulated from one another to minimize energy losses therebetween such that ice is selectively and directionally formed at the target site. The cooling compartment can include a temperature sensor and an exhaust tube to guide a fluid or gas that exhibits a Joule Thomson cooling effect through the probe. The heating compartment can include a temperature sensor and a heater cartridge having a heater zone. The controller of the cryoablation system can process temperature measurement data from the sensors of the heating and cooling compartments and regulate the heater zone based on the temperature measurement data processing to maintain a temperature that is sufficiently constant to mitigate or prevent formation of ice on the heating compartment.

A left atrial appendage (LAA) occluder and an occluding system are provided. The LAA occluder includes a sealing portion and an ablation portion arranged in the sealing portion, as well as a hollow proximal connector at a proximal end of the sealing portion. The ablation portion is connected to the proximal connector. The ablation portion is used to freeze an LAA after being injected with cryogen so as to form an annular isolation band on an inner wall of the LAA for blocking the conduction of electrical signals between the LAA and a left atrium.

Transducer-based systems and methods may be configured to display a graphical representation of a transducer-based device, the graphical representation including graphical elements corresponding to transducers of the transducer-based device, and also including between graphical elements respectively associated with a set of the transducers and respectively associated with a region of space between the transducers of the transducer-based device. Selection of graphical elements and/or between graphical elements can cause activation of the set of transducers associated with the selected elements. Transducer activation characteristics, such as initiation time, activation duration, activation sequence, and energy delivery characteristics, can vary based on numerous factors. Visual characteristics of graphical elements and between graphical elements can change based on an activation-status of the corresponding transducers. Activation requests for a set of transducers can be denied if it is determined that a transducer in the set of transducers is unacceptable for activation.

Provided herein are catheter devices, systems, and methods to ablate a tissue location. The devises, systems, and methods disclosed herein include ablation systems including a catheter system with inner and outer shafts that deliver an ablation medium (e.g., a cryogenic ablation medium) to a body lumen and evacuate the ablation medium from the body lumen. In some embodiments, devices, systems, and methods disclose herein relate to monitoring and regulating pressure, temperature, or other conditions within a body lumen during an ablation procedure.