A cryo formulation-based microneedle device for ocular delivery of bioactive therapeutic agents. The microneedle device includes: one or more microneedle patches each including an array of miniaturized needles, wherein each miniaturized needle defining a base end and a tip; and a substrate to which the base end of the array of miniaturized needles is attached or integrated thereto; wherein the microneedle patch is in a cryo status; wherein each of the one or more microneedle patch is adapted to be applied on cornea of an eye, in which the miniaturized needles penetrates into the eye; and wherein the miniaturized needles is further arranged to melt so as to release one or more bioactive therapeutic agents into the eye to achieve a targeted therapeutic effect.

Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and/or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and/or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.

A tethered system for cryogenic treatment is disclosed in which a hand piece having an elongate probe with a distal tip and a flexible length, at least one infusion lumen positioned through or along the elongate probe, and a liner may be tethered to a base station having a reservoir of a cryoablative fluid via a connection having an elongate flexible body. The connection defines at least one fluid lumen for delivery of the cryoablative fluid from the reservoir and to the infusion lumen within the hand piece.

A medical device having a catheter and a fluid delivery conduit entirely disclosed within a portion of the catheter. The catheter may have a thermally transmissive region in fluid communication with the fluid delivery conduit and a rod disposed within at least a portion of the fluid delivery conduit. The medical device may control variable fluid flow with the ability to modify the effective cross-sectional area of the fluid delivery conduit available for fluid flow. Additional configurations provided herein may allow for the selective manipulation of a footprint or therapeutic pattern achievable with the medical device during a single procedure, negating the need for the removal and insertion of multiple devices to achieve the same variations in treatment geometry or characteristics.

The present invention discloses a cryoablation catheter, including: a main tube having a distal end, a proximal end, and at least one lumen; an expansion element, with which the distal end of the main tube is sleeved; a fluid delivery tube extending into an expansion element through the lumen of the main tube, an opening being provided at a distal end of the fluid delivery tube, and a cryogenic fluid being ejected out through the opening; a fluid recovery passage extending into the expansion element through the lumen of the main tube, a distal end of the fluid recovery passage being communicated with a recovery hole at the distal end of the main tube, and the cryogenic fluid flowing into the fluid recovery passage through the recovery hole; wherein the opening is linearly disposed in a length direction of the distal end of the main tube. With the cryoablation catheter according to the present invention, an ablation line may be formed on tissue to be ablated, and through single entirely-lined ablation or a few times of entirely lined continuous ablation, the one-time success rate of ablation is close to the success rate of a surgery.

An applicator for applying cryogenic fluid to a treatment area is described, the applicator comprising: a reservoir (12) configured to contain a cryogenic fluid comprising a gas phase (G) and a liquid phase (L). A nozzle (20) extends from a proximal end arranged in fluid communication with the reservoir (12) to an open distal end (21) for application of fluid to a treatment area. An actuatable valve is provided to selectively allow a flow of cryogenic fluid from the reservoir (12) through the distal end of the nozzle (20). A spacer (14) extends distally beyond the distal end (21) of the nozzle (20), the spacer (14) comprising a skin contacting surface (14a) at its distal end. A porous material (16) is provided between the distal end (21) of the nozzle (20), at least between the open end of the nozzle and the skin contacting surface of the spacer.

Ablation catheters and systems include flexible catheter tips with a distal needle or ports for delivery of an ablative agent to a target tissue. Pressure monitoring during ablation ensure operation is performed within safe limits and with desired efficacy. Positioning elements help maintain the devices in the proper position with respect to the target tissue and also prevent the passage of ablative agent to normal tissues.

Provided are medical devices that comprise first and second tubes with a sealed insulating space formed therebetween, the devices being steerable and configured to deliver a fluid to a treatment site on or within a subject. The tubes of the devices can include corrugations so as to allow for bendability of the devices. Also provided are methods of using the disclosed devices.

In an example, a cryotherapy system includes a base station, a cryotherapy applicator, and a cryogen conduit configured to couple the cryotherapy applicator to the base station and supply a cryogen from the base station to the cryotherapy applicator. The base station includes a housing including a canister receptacle that is configured to receive a canister containing the cryogen. The cryotherapy applicator includes a handle, a shaft extending from the distal end of the handle, and an end-effector coupled to the shaft. The end-effector is configured to use the cryogen to ablate a target tissue. An entirety of the cryotherapy applicator is movable relative to an entirety of the base station while the cryogen conduit couples the cryotherapy applicator to the base station.

The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCR) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.