Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.

Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.

Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.

Compositions and methods for isolating L-glufosinate from a composition comprising L-glufosinate and glutamate are provided. The method comprises converting the glutamate to pyroglutamate followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The composition comprising L-glufosinate and glutamate is subjected to an elevated temperature for a sufficient time to allow for the conversion of glutamate to pyroglutamate, followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The glutamate alternatively may be converted to pyroglutamate by enzymatic conversion. The purified L-glufosinate is present in a final composition at a concentration of 90% or greater of the sum of L-glufosinate, glutamate, and pyroglutamate. In some embodiments, a portion of the glutamate in the starting composition may be separated from the L-glufosinate using a crystallization step. Solid forms of L-glufosinate materials, including crystalline L-glufosinate ammonium, are also described.

The present invention relates primarily to processes for preparing particular phosphorus-containing -aminonitriles of the formulae (Ia) and (Ib) defined hereinafter from corresponding phosphorus-containing cyanohydrin esters and to the use thereof for preparation of glufosinate or of glufosinate salts. The present invention further relates to a process for preparing glufosinate or glufosinate salts.

Flame retardant mixtures comprising as component (A) 30% to 99.9% by weight of dialkylphosphinic salts of the formula (II), a and b may be the same or different and are each independently 1 to 9, and where the carbon chains may be linear, branched or cyclic and M is Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Li, Na, K and/or a protonated nitrogen base and m is 1 to 4, as component (B) 0.1% to 70% by weight of alkyl hydroxyalkylphosphinyl organylcarboxylic acid salts and/or ester salts of the formula (I) where R1CyH2y+1 with y=2 to 8, R2, R3, R4, R5, R6 are the same or different and are each independently H, CxH2x+1, CxH2x1, CxH2x3, CxH2xCO2X, CxH2x2CO2X, CxH2x4CO2X, (C2H3CO2X)u and u=0 to 1000000, CO2X, CxH2x(P(O)(OM)R1), CxH2x2(P(O)(OM)R1)(CO2X) and/or CH2CO2X, where, in the R1, R2, R3, R4, R5 and R6 groups, the carbon chains may be linear, branched or cyclic, M is Mg, Ca, Al, Sb, Sn, Ge, Fe, Ti, Zr, Zn, Ce, Bi, Sr, Mn, Li, Na, K, H and/or N-containing cations, x is 1 to 25, X is H, M, CzH2z+1 and z is 1 to 8, with the proviso that at least one of the R2, R3, R4, R5, R6 groups is not H, and the compounds of formula (II) and formula (I) are different compounds.

The invention relates to agriculture, and specifically to regulators of plant growth and development that can be used for the pre-sowing treatment of cereal crop seeds and are in the form of bis(oxymethyl)phosphinic acid and biogenic metal salts thereof with the general formula (I) Me.sup.n[OP(O)(CH.sub.2OH).sub.2].sub.1, where n may be 1 or 2 and Me may be any of the following: H, Na, Ca, Mg, Co, Cu, Zn, Mn. The claimed compounds of formula I are effective regulators of plant growth and development when acting in concentrations of 1.Math.10.sup.7-1.Math.10.sup.12%. Pre-sowing treatment of the seeds of cereal crops, namely wheat, corn and rice, by means of the claimed compounds increases germination energy and germination capacity up to 13%, also increases plant vigor, and rootlet and shoot lengths increase up to 36%. Crop harvests increase and the quality of the resulting grain improves, which expands the range of effective, environmentally friendly plant growth and development regulators that act at the level of natural phytohormones.

The present invention relates to a method for preparing glufosinate or an analogue and an intermediate thereof. The method comprises: a) reacting a compound of formula (II), an alcohol of formula (III) and a compound of formula (V); and b) hydrolyzing the product of the reaction above to obtain glufosinate of formula (IV) or an analogue thereof.

The present invention relates to a method for preparing glufosinate or analogues thereof.

Solid forms of L-glufosinate materials, including crystalline L-glufosinate ammonium, are described.