Systems for treating a subject's tissue can include a thermally conductive cup with vacuum features configured to facilitate removal of air located between the cup and the subject's skin. The vacuum features can extend along cup to provide airflow paths to a vacuum port. The applicator can cool and/or heat the retained tissue to affect targeted tissue. After the treat period, the vacuum can be reduced or stop and the applicator can be removed from the subject.

A handle for a surgical instrument, in particular a cryosurgical instrument, comprising a grip element and at least one sheathing tube that is inserted into the grip element and connected with said grip element in a fluid-tight manner in a connecting region. At least one support element is coaxially configured and arranged in the cavity of the sheathing tube such that the sheathing tube is clamped in place between the grip element and the support element in the connecting region.

The invention disclosed here generally relates to devices that can modify a property of a nerve. Specifically, the subject invention is contemplated to modify the posterior nasal nerve signal conduction in such a way so as to reduce the signals transmitted to the nasal cavity. Reduction or interruption of the nerve signals results in the reduction of the distal organ activity. In particular, embodiments of the present invention allow for increased lateral contact or apposition of the target tissue region having at least one posterior nasal nerve with the end effector surface by lateral and/or longitudinal translation of the end effector relative to the surgical probe shaft. This improved lateral surface contact has several benefits, including improved patient outcomes and patient safety as the end effector is adequately in contact with target tissue for subsequent ablation therapy.

A method and system for automated and semi-automated predictable, consistent, safe, effective, and lumen-specific and patient-specific cryospray treatment of airway tissue in which treatment duration is automatically set by the system following entry of patient information and treatment location information into the system by the user, and treatment spray is automatically stopped by the system when the automatically selected treatment duration has been achieved as determined by the system.

A cryogenic probe, comprising: (a) a handle, (b) a shaft disposed distally on the handle, the shaft comprising a generally rigid proximal portion and a generally malleable distal portion, and (c) an active tip disposed distally on the shaft, where the shaft comprises a supply conduit configured to supply a cryogenic fluid to the active tip, an exhaust conduit configured to exhaust spent cryogenic fluid from the active tip, and a vacuum insulating layer disposed around the supply conduit and the exhaust conduit.

Cryosurgery systems, delivery apparatus and methods that provide for the application of cryogen to a treatment area via a low-profile, low pressure, closed-tipped probe. Cryogen is circulated through the probe, and vented to outside of the body, optionally under vacuum pressure, which contributes to increased cryogen throughput.

A method and system for automated and semi-automated predictable, consistent, safe, effective, and lumen-specific and patient-specific cryospray treatment of airway tissue in which treatment duration is automatically set by the system following entry of patient information and treatment location information into the system by the user, and treatment spray is automatically stopped by the system when the automatically selected treatment duration has been achieved as determined by the system.

In an embodiment, a method for detecting leaks in a shaft of a cryoablation system includes placing a vacuum pump in fluid communication with a return tube and a supply tube; pulling a vacuum within the supply tube and the return tube; after pulling the vacuum for a predetermined amount of time, measuring a vacuum pressure within the supply tube and the return tube; and analysis of the vacuum pressure to assist with identifying leaks in the system.

A controller for a cooled radiofrequency ablation system is configured to sequentially activate a plurality of pump assemblies with a pump activation time delay between the activation of each of the plurality of pump assemblies, measure a temperature drop delay time for each of a plurality of cooled radiofrequency ablation probes, map each respective pump assembly of the plurality of pump assemblies to a corresponding cooled radiofrequency ablation probe of the plurality of cooled radiofrequency ablation probes based on the temperature drop delay time and an activation time of each of the plurality of pump assemblies, and confirm the mapping of each respective pump assembly to the corresponding cooled radiofrequency ablation probe by comparing, for each of the plurality of cooled radiofrequency probes, the measured temperature drop delay time to an expected temperature drop delay time.

The present invention generally relates to improved medical devices, systems, and methods. In many embodiments, devices, systems, and methods for locating and treating a target nerve with integrated cold therapy and electrical stimulation systems are provided. For example, nerve stimulation and cryoneurolysis may be delivered concurrently or alternately with the cryo-stimulation device. In some embodiments, the device may be operated by a single operator or clinician. Accordingly, embodiments of the present disclosure may improve nerve targeting during cryoneurolysis procedures. Improvements in nerve localization and targeting may increase treatment accuracy, physician confidence in needle placement during treatment, and clinical efficacy and safety. In turn, such improvements may decrease overall treatment times, the number of repeat treatments, and the re-treatment rate. Further, additional improvements in nerve localization and targeting may reduce the number of needle insertions, applied treatment cycles, and may also reduce the number of cartridge changes.