A device for therapeutic neuromodulation in a nasal region can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

A cryoablation system is provided that can assume a directional activated state and includes a cryoablation probe and a controller. The cryoablation probe has an active region that includes a cooling compartment and an opposing heating compartment that are thermally insulated from one another to minimize energy losses therebetween such that ice is selectively and directionally formed at the target site. The cooling compartment can include a temperature sensor and an exhaust tube to guide a fluid or gas that exhibits a Joule Thomson cooling effect through the probe. The heating compartment can include a temperature sensor and a heater cartridge having a heater zone. The controller of the cryoablation system can process temperature measurement data from the sensors of the heating and cooling compartments and regulate the heater zone based on the temperature measurement data processing to maintain a temperature that is sufficiently constant to mitigate or prevent formation of ice on the heating compartment.

The present disclosure relates to an ablation device, which relates to the technical field of cryoablation treatments, and is used for solving the technical problem of an excessive burden on an operator caused by the volume of a delivery device being too large. The ablation device of the disclosure comprises an ablation needle and a working medium transmission device connected to the ablation needle. The working medium transmission device comprises a first delivery tube and a second delivery tube. The first delivery tube and the second delivery tube are configured to be of split structures that are independent of each other, such that the structure of the working medium delivery device at the rear end of the ablation needle is smaller and lighter, and thus the burden on the operator's operation can be reduced, making the operation to be more flexible and convenient.

Provided are devices and methods for anesthetizing a patient undergoing surgery, and/or pain block procedures. In certain embodiments the disclosure provides a curved cryoneurolysis needle. In some forms, the methods include inserting at least one cryoneurolysis needle into a target region of the patient, and cooling the cryo-needle to inhibit the target intercostal nerve.

A handpiece including a cooling device for a skin care device used for improving or treating a skin. The handpiece includes: a case; a cooling head part mounted at a fore-end inside the case and configured to generate cooling energy; a cooling plate part which has a rear end for receiving the cooling energy from the cooling head part and has a fore-end that cools a treatment site through the contact with the skin; a needle part which includes needles for penetrating into the skin during the procedure for skin care; and a linear motor unit which includes a driving unit configured to penetrate the cooling head part is coupled to the needle, and a motor unit located at a rear of the cooling head part and inducing a linear movement of the needle part by a forward and backward movement of a driving unit.

A method for anesthetizing a human patient undergoing surgery and/or pain block procedure, the method comprising sterilizing the patient's skin including a target region, the target region including a surgical site including the patient's spine; inserting at least one cryo-needle into a first tissue region, the cryo-needle having a distal end configured to cool surrounding patient tissue, the first tissue region comprising soft tissue superficial to the one or more vertebra and on a first lateral side of the patients spine; cooling the distal end of the cryo-needle to cause cooling of surrounding patient tissue thus inhibiting one or more sensory nerves in the surrounding patient tissue; thereafter, performing spinal surgery on the patient's spine at the surgical site; and, thereafter, performing an erector spinae plane block to further inhibit nerves post-operatively in the target region.

Embodiments described herein are directed to a system for providing alternating freeze and thaw cycles. The system includes a controller, a vessel for holding a working fluid, a pressure generator, a cooler, a cooler heat exchanger, a heater, a heater heat exchanger, a check valve, and a treatment instrument. In some embodiments, the treatment instrument includes a distal end, a proximal end, a connecting portion adjacent to the proximal end, a needle element adjacent the distal end, a handle portion disposed between the proximal and distal end, and a depth-limiting element to limit an injection depth of the needle element.

Disclosed herein are devices, systems, and methods for monitoring a formation of an iceball at a cryoablation needle. An example method includes receiving an impedance from at least one electrode in an electrode arrangement that is disposed at a cryoablation needle distal portion. The electrode arrangement is configured to engage the iceball as the iceball is formed over the cryoablation needle distal portion so as to cause a change in the impedance. The example method includes determining one or more physical attributes of the iceball based on a rate of the change in the impedance.

A system for deploying needles in tissue includes a controller and a visual display. A treatment probe has both a needle and tines deployable from the needle which may be advanced into the tissue. The treatment probe also has adjustable stops which control the deployed positions of both the needle and the tines. The adjustable stops are coupled to the controller so that the virtual treatment and safety boundaries resulting from the treatment can be presented on the visual display prior to actual deployment of the system.

A cryosurgical instrument includes a feed line for conveying fluid into an expansion chamber. The feed line has a capillary line section that terminates in the expansion chamber and forms an aperture for the fluid to undergo the Joule-Thomson effect. The flow cross-section of the feed line decreases in at least one transition section of the feed line in the form of a funnel. Following each transition section there preferably follows a step section, in which latter section the flow cross-section is preferably largely constant. The last step section is preferably formed by the capillary line section. Due to the acceleration of the fluid in the transition sections and the abating of pressure fluctuations in the capillary tube section and, optionally in the additional step sections, the expansion range in the expansion chamber is increased, without impeding the backflow of the expanded gas out of the expansion chamber.