The present invention contemplates a method for synthesizing [.sup.18F] fluoride complexes suitable for performing radio-labeling reactions to generate [.sup.18F] fluorinated species for use as imaging agents. The present invention further contemplates kits for making [.sup.18F] fluoride complexes suitable for performing radio-labeling reactions to generate [.sup.18F] fluorinated species. The present invention further contemplates a method of using [.sup.18F] fluoride prosthetic group for targeted tissue and disease imaging.

The present invention contemplates a method for synthesizing [.sup.18F] fluoride complexes suitable for performing radio-labeling reactions to generate [.sup.18F] fluorinated species for use as imaging agents. The present invention further contemplates kits for making [.sup.18F] fluoride complexes suitable for performing radio-labeling reactions to generate [.sup.18F] fluorinated species. The present invention further contemplates a method of using [.sup.18F] fluoride prosthetic group for targeted tissue and disease imaging.

Provided is a method for purifying a phosphorus-containing olefin compound salt as a raw material or an intermediate that is useful to increase the purity of a target product in a method for producing an olefin compound and that can be applied to the production method, and a method for producing an olefin compound using a purified product obtained thereby. Specifically, provided is a method for purifying a phosphorus-containing olefin compound salt, comprising reprecipitating and/or recrystallizing a solid comprising at least one phosphorus-containing olefin compound salt selected from the group consisting of: a phosphorus-containing olefin compound salt A represented by the following formula (1): ##STR00001## wherein X.sub.1 and X.sub.2 are each independently F, Cl, Br, I, or H; W.sup.+s are the same or different and each is a monovalent cation comprising PR.sub.3 or P(OR).sub.3, provided that Rs are groups having a saturated or unsaturated structure containing C and H, are optionally bonded together to form a ring, and optionally contain an atom other than C and H; three Rs included in R.sub.3 and (OR).sub.3 are optionally the same or different; and M.sup. is a monovalent anion comprising an atom or a compound; and a phosphorus-containing olefin compound salt B represented by the following formula (2): ##STR00002## wherein X.sub.1, X.sub.2, W.sup.+, and M.sup. are as defined above, and Y is F, Cl, Br, I, H, an alkyl group, an alkyl ether group, a fluoroalkyl group, or a fluoroalkyl ether group; in a solvent, thereby obtaining a purified product of the phosphorus-containing olefin compound salt.

Provided is a method for purifying a phosphorus-containing olefin compound salt as a raw material or an intermediate that is useful to increase the purity of a target product in a method for producing an olefin compound and that can be applied to the production method, and a method for producing an olefin compound using a purified product obtained thereby. Specifically, provided is a method for purifying a phosphorus-containing olefin compound salt, comprising reprecipitating and/or recrystallizing a solid comprising at least one phosphorus-containing olefin compound salt selected from the group consisting of: a phosphorus-containing olefin compound salt A represented by the following formula (1): ##STR00001## wherein X.sub.1 and X.sub.2 are each independently F, Cl, Br, I, or H; W.sup.+s are the same or different and each is a monovalent cation comprising PR.sub.3 or P(OR).sub.3, provided that Rs are groups having a saturated or unsaturated structure containing C and H, are optionally bonded together to form a ring, and optionally contain an atom other than C and H; three Rs included in R.sub.3 and (OR).sub.3 are optionally the same or different; and M.sup. is a monovalent anion comprising an atom or a compound; and a phosphorus-containing olefin compound salt B represented by the following formula (2): ##STR00002## wherein X.sub.1, X.sub.2, W.sup.+, and M.sup. are as defined above, and Y is F, Cl, Br, I, H, an alkyl group, an alkyl ether group, a fluoroalkyl group, or a fluoroalkyl ether group; in a solvent, thereby obtaining a purified product of the phosphorus-containing olefin compound salt.

The present invention relates to an analytical method that includes providing a sample potentially containing a chiral analyte that can exist in stereoisomeric forms, and providing a probe selected from the group consisting of coumarin-derived Michael acceptors, dinitrofluoroarenes and analogs thereof, arylsulfonyl chlorides and analogs thereof, arylchlorophosphines and analogs thereof, aryl halophosphites, and halodiazaphosphites. The sample is contacted with the probe under conditions to permit covalent binding of the probe to the analyte, if present in the sample; and, based on any binding that occurs, the absolute configuration of the analyte in the sample, and/or the concentration of the analyte in the sample, and/or the enantiomeric composition of the analyte in the sample is/are determined. The probe may be a coumarin-derived Michael acceptor, a di nitrofluoroarene or analog thereof, an arylsulfonyl chloride or analog thereof, an arylchlorophosphine or analog thereof, an aryl halophosphite, or a halodiazaphosphite.

The present invention relates to an analytical method that includes providing a sample potentially containing a chiral analyte that can exist in stereoisomeric forms, and providing a probe selected from the group consisting of coumarin-derived Michael acceptors, dinitrofluoroarenes and analogs thereof, arylsulfonyl chlorides and analogs thereof, arylchlorophosphines and analogs thereof, aryl halophosphites, and halodiazaphosphites. The sample is contacted with the probe under conditions to permit covalent binding of the probe to the analyte, if present in the sample; and, based on any binding that occurs, the absolute configuration of the analyte in the sample, and/or the concentration of the analyte in the sample, and/or the enantiomeric composition of the analyte in the sample is/are determined. The probe may be a coumarin-derived Michael acceptor, a di nitrofluoroarene or analog thereof, an arylsulfonyl chloride or analog thereof, an arylchlorophosphine or analog thereof, an aryl halophosphite, or a halodiazaphosphite.