[Problem]

To provide an alkenyl phosphorus compound.

[Means to Solve the Problem]

The method for manufacturing an alkenyl phosphorus compound according to the present invention is a method in which a specific phosphorus compound and a specific alkynyl compound are reacted in the presence of a transition metal complex and a Lewis acid, thereby giving an alkenyl phosphorus compound.

A compound according to Formula (I), or a pharmaceutically acceptable salt thereof:

##STR00001##

wherein R.sup.1 and R.sup.2 are each independently selected from optionally substituted C.sub.1-6-alkyl and optionally substituted aryl; R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are each independently selected from the group consisting of H, halo, optionally substituted C.sub.1-6-alkyl, and optionally substituted C.sub.1-6 alkoxy; and R.sup.7 is a phosphorus containing moiety, wherein a phosphorus atom is bonded to Au.

This application is directed to use of transition metal-ligand complexes to hydrogenate fluorinated esters and carboxamides into fluorinated hemiacetals. Methods for synthesis of certain ligands are also provided.

An object of a first aspect of the present invention is to provide a radical generating catalyst that can generate (produce) radicals under mild conditions. In order to achieve the above object, a first radical generating catalyst according to the first aspect of the present invention is characterized in that it includes ammonium and/or a salt thereof. A second radical generating catalyst according to the first aspect of the present invention is characterized in that it includes an organic compound having Lewis acidic properties and/or Brønsted acidic properties.

Provided herein are compounds of formula (II):

##STR00001##

or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein m, n, p, R.sup.1, R.sup.2, R.sup.3, L.sup.1, L.sup.2, L.sup.3, R.sup.4, X.sup.1, X.sup.2, X.sup.3, and X.sup.4 are as defined herein. Also provided are methods of preparing compounds of formula (II), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided are methods of inhibiting APOL1 and methods of treating an APOL1-mediated disease, disorder, or condition in an individual.

The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.

The present invention provides a phosphorus-containing compound characterized by being a compound represented by the following structure: ##STR00001## the compound is a novel immune cell migration inhibitor. The compound has good hydrophilicity and can be developed into eye drops. The compound has a strong inhibitory ability to immune cell migration and can relieve the symptoms of most dry-eye patients.

The present application relates to a compound of Chemical Formula 1 and an organic light emitting device including the same.

The present invention is directed to a semiconducting material comprising: i) a compound according to formula (I) wherein R.sup.1, R.sup.2 and R.sup.3 are independently selected from C.sub.1-C.sub.30-alkyl, C.sub.3-C.sub.30 cycloalkyl, C.sub.2-C.sub.30-heteroalkyl, C.sub.6-C.sub.30-aryl, C.sub.2-C.sub.30-heteroaryl, C.sub.1-C.sub.30-alkoxy, C.sub.3-C.sub.30-cycloalkyloxy, C.sub.6-C.sub.30 aryloxy, and from structural unit having general formula E-A-, wherein—A is a C.sub.6-C.sub.30 phenylene spacer unit, and—E is an electron transporting unit that is selected from C.sub.10-C.sub.60 aryl and C.sub.6-C.sub.60 heteroaryl comprising up to 6 heteroatoms independently selected from O, S, P, Si and B and that comprises a conjugated system of at least 10 delocalized electrons, and—at least one group selected from R.sup.1, R.sup.2 and R.sup.3 has the general formula E-A-; and ii) at least one complex of a monovalent metal having formula (II) wherein—M.sup.+ is a positive metal ion bearing a single elementary charge, and each of A.sup.1, A.sup.2, A.sup.3 and A.sup.4 is independently selected from H, substituted or unsubstituted C.sub.6-C.sub.20 aryl and substituted or unsubstituted C.sub.2-C.sub.20 heteroaryl, wherein a heteroaryl ring of at least 5 ring-forming atoms of the substituted or unsubstituted C.sub.2-C.sub.20 heteroaryl comprises at least one hetero atom selected from O, S and N. ##STR00001##

The embodiments provide a fluorescent rare earth complex having strong emission intensity and excellent durability, and also provide a security medium using the complex. The rare earth complex according to the embodiment comprises a rare earth ion, a diphosphine dioxide ligand and a β-diketone ligand wherein two phosphorus atoms contained in the diphosphine dioxide ligand individually have substituents different from each other.