This invention relates to compounds that are useful as cancer therapies. The compounds comprise derivatives of tetracycline antibiotics, e.g. doxycycline, having a phosphonium cation tethered to the tetracycline tetracycle. The invention also relates to methods of using said compounds and to pharmaceutical formulations comprising said compounds.

A preparation method for glufosinate or a salt, an enantiomer or a mixture of enantiomers in all ratios thereof, the method being especially suitable for the preparation of glufosinate, and greatly shortening steps in an existing preparation process. Especially in the preparation of L-glufosinate, the product can effectively retain the ee value of the raw materials.

A phosphonium-based ionic liquid compound including a particular phosphonium cation and a carboxylate anion. A lubricant composition including it, and its use as a detergent and anti-corrosion additive in a lubricant, in particular a marine lubricant.

The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: ##STR00001##
The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

Disclosed herein are the methods of using di-cationic or di-anionic compounds, which are derived from primary amine through an aza-Michael addition with an activated olefin, in a corrosion control composition to mitigate corrosion of a surface in a water system. The disclosed methods or compositions are found to be more effective than those methods or compositions including commonly used single quaternary compounds for mitigating corrosion for a metal surface in water systems.

Cationic pillar[n]arenes, e.g., positively charged poly-ammonium, poly-phosphonium and poly-imidazolium pillar[5-6]arene derivatives are capable of inhibiting or preventing biofilm formation, and facilitating existing biofilm decomposition. A composition for inhibiting or disrupting biofilm, e.g., bacterial or fungal biofilm, formation, or reducing biofilm, can include a pharmaceutically acceptable carrier, and a cationic pillar[n]ene.

A phosphorus-containing ionic liquid, a phosphorus-containing a flame retardant additive, and a preparation method thereof are provided. Also provided are co-monomer salt compositions for flame retardant polymers. Also provided are polymers that comprise the phosphorus-containing flame retardant ionic liquid or flame retardant co-monomer salt. The resin composition may be used to make various articles, including fibers, fabrics, and yarns.

The present disclosure provides a polymeric composition including a thermoplastic polymer and an ionic liquid compound, wherein the ionic liquid compound improves the melt flow rate of the polymeric composition. The present disclosure also provides a method of preparing a polymeric composition with improved melt flow rate by mixing an ionic liquid compound with a thermoplastic polymer to obtain the polymeric composition.

The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II):

##STR00001##

processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.

A process for preparing a cationic species [Cat+] for an ionic liquid, said process comprising reacting a reagent (1) H 2 N-L-[Z] with a reagent (2) LG-L 2-EDG, to form a cationic species EDG-L 2-[Z+]-L-N(L 2-EDG) 2, wherein the process is carried out in a sealed reactor at a temperature of at least 100° C.