Patent classifications
C07F9/572
Water soluble fluorescent or colored dyes comprising conjugating groups
Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, L.sup.1, L.sup.3, L.sup.4, L.sup.6, L.sup.7, L.sup.8, M.sup.1, M.sup.2, q, w and n are as defined herein. Methods associated with preparation and use of such compounds are also provided. ##STR00001##
Method for treating anxiety disorders, headache disorders, and eating disorders with psilocybin
- Derek John Londesbrough ,
- Christopher Brown ,
- Julian Scott Northen ,
- Gillian Moore ,
- Hemant Kashinath PATIL ,
- David E. Nichols ,
- Megan CROAL ,
- Hans Åke ERIKSSON ,
- George GOLDSMITH ,
- Molly Tabitha HICKEY ,
- Shaun HURLEY ,
- Ekaterina MALIEVSKAIA ,
- Lindsey MARWOOD ,
- Drummond E-Wen Joe MCCULLOCH ,
- Laurie Emma MEDHURST ,
- Nathan POULSEN ,
- Aslihan SELIMBEYOGLU ,
- Anaïs SOULA ,
- Amanda Tan SHUXIANG ,
- Manon Cecile Elisabeth VERAART ,
- Tobias Patrick WHELAN ,
- Lars Christian WILDE ,
- Stephen WRIGHT
The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.
PSILOCIN DERIVATIVES AS SEROTONERGIC PSYCHEDELIC AGENTS FOR THE TREATMENT OF CNS DISORDERS
The present application relates to psilocin derivatives of Formula (I), to processes for their preparation, to compositions comprising them and to their use in activation of a serotonin receptor in a cell, as well as to treating diseases, disorders or conditions by activation of a serotonin receptor in a cell.
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Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
This invention relates to the large-scale production of psilocybin for use in medicine. Move particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
The present invention provides a compound of formula (II): an inhibitor of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases. Its prodrugs are disclosed. ##STR00001##
3-pyrrolidine-indole derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
The present application relates to 3-cyclic amine-indole derivatives of general Formula (I), to processes for their preparation, to compositions comprising them and to their use in activation of a serotonin receptor in a cell, as well as to treating diseases, disorders or conditions by activation of a serotonin receptor in a cell. The diseases, disorders or conditions include, for example, psychosis, mental illnesses, and other neurological diseases, disorders and conditions. ##STR00001##
AMIDE-LINKED CONJUGATE COMPOUNDS AND USES THEREOF
The present invention relates to conjugate compounds and methods of making and using same.
AMIDE-LINKED CONJUGATE COMPOUNDS AND USES THEREOF
The present invention relates to conjugate compounds and methods of making and using same.
PSILOCIN DERIVATIVES AS SEROTONERGIC PSYCHEDELIC AGENTS FOR THE TREATMENT OF CNS DISORDERS
The present application relates to psilocin derivatives of Formula (I), to processes for their preparation, to compositions comprising them and to their use in activation of a serotonin receptor in a cell, as well as to treating diseases, disorders or conditions by activation of a serotonin receptor in a cell.
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Thermally Activated Delayed Fluorescent Material Based on 9,10-Dihydro-9,9-dimethylacridine Analogues for Prolonging Device Longevity
Thermally activated delayed fluorescent compounds and uses thereof are described. The thermally activated delayed fluorescent compounds are an analogues of 9,10-dihydro-9,9-dimethylacridine compounds.