Disclosed herein are novel quinone methide analog precursors and embodiments of a method and a kit of using the same for detecting one or more targets in a biological sample. The method of detection comprises contacting the sample with a detection probe, then contacting the sample with a labeling conjugate that comprises an enzyme. The enzyme interacts with a quinone methide analog precursor comprising a detectable label, forming a reactive quinone methide analog, which binds to the biological sample proximally to or directly on the target. The detectable label is then detected. In some embodiments, multiple targets can be detected by multiple quinone methide analog precursors interacting with different enzymes without the need for an enzyme deactivation step.

An ultraviolet (UV) light stabilizing polymeric filler material includes a particle that is surface modified to include a hydroxyphenyl-benzotriazole (HPB) derivative functionality.

The present invention relates to a benzotriazole derivative, a preparation process thereof and the use thereof in preparation of the lubricating oil composition. The structure of the benzotriazole derivative of the present invention is shown by general formula (I). The benzotriazole derivative of the present invention, as the anti-wear additive for lubricating oil, not only has an excellent extreme pressure anti-wear property, but also has one or more excellent properties of thermal oxidation stability, corrosion resistance, rust resistance and anti-friction performance.

##STR00001##

In the general formula (I), each of the group(s) and the number(s) are defined as in the description.

The present invention relates to a benzotriazole derivative, a preparation process thereof and the use thereof in preparation of the lubricating oil composition. The structure of the benzotriazole derivative of the present invention is shown by general formula (I). The benzotriazole derivative of the present invention, as the anti-wear additive for lubricating oil, not only has an excellent extreme pressure anti-wear property, but also has one or more excellent properties of thermal oxidation stability, corrosion resistance, rust resistance and anti-friction performance.

##STR00001##

In the general formula (I), each of the group(s) and the number(s) are defined as in the description.

A compound represented by formula (I) and a pharmaceutically acceptable salt thereof, as well as an antifungal application of the compound.

##STR00001##

Disclosed herein are novel quinone methide analog precursors and embodiments of a method and a kit of using the same for detecting one or more targets in a biological sample. The method of detection comprises contacting the sample with a detection probe, then contacting the sample with a labeling conjugate that comprises an enzyme. The enzyme interacts with a quinone methide analog precursor comprising a detectable label, forming a reactive quinone methide analog, which binds to the biological sample proximally to or directly on the target. The detectable label is then detected. In some embodiments, multiple targets can be detected by multiple quinone methide analog precursors interacting with different enzymes without the need for an enzyme deactivation step.

Disclosed herein are novel quinone methide analog precursors and embodiments of a method and a kit of using the same for detecting one or more targets in a biological sample. The method of detection comprises contacting the sample with a detection probe, then contacting the sample with a labeling conjugate that comprises an enzyme. The enzyme interacts with a quinone methide analog precursor comprising a detectable label, forming a reactive quinone methide analog, which binds to the biological sample proximally to or directly on the target. The detectable label is then detected. In some embodiments, multiple targets can be detected by multiple quinone methide analog precursors interacting with different enzymes without the need for an enzyme deactivation step.

A compound of formula (I) for use in the prevention or treatment of a bacterial infection wherein: P.sup.X is selected from the group consisting of (P1), (P2) and (P3).

##STR00001##

A compound of Formula (II): for use in the prevention or treatment of a bacterial infection.

##STR00001##

This invention is related to the field of PCSK9 biology and the composition and methods of use of small molecule ligands for modulation of PCSK9 biological activity. In particular, the invention provides compositions of small molecule compounds that modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9. Binding these small molecule ligands to PCSK9 alters the conformation of the protein, modifying the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol. High LDL cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunction; thus, there is also utility for small molecule ligands that can raise LDL levels.