Systems, device and methods treat target tissue to provide a therapeutic benefit to the patient. A tissue treatment device comprises a tissue treatment element constructed and arranged to treat target tissue, such as duodenal mucosa tissue.

Example systems and techniques for denervation, for example, renal denervation. In some examples, a processor determines one or more tissue characteristics of tissue proximate a target nerve and a blood vessel. The processor may generate, based on the one or more tissue characteristics, an estimated volume of influence of denervation therapy delivered by a therapy delivery device disposed within the blood vessel. The processor may generate a graphical user interface including a graphical representation of the tissue proximate the target nerve and the blood vessel and a graphical representation of the estimated volume of influence.

Example systems and techniques for denervation, for example, renal denervation. In some examples, a processor determines one or more tissue characteristics of tissue proximate a target nerve and a blood vessel. The processor may generate, based on the one or more tissue characteristics, an estimated volume of influence of denervation therapy delivered by a therapy delivery device disposed within the blood vessel. The processor may generate a graphical user interface including a graphical representation of the tissue proximate the target nerve and the blood vessel and a graphical representation of the estimated volume of influence.

A system includes an intravascular medical device and a therapeutic medical device. The intravascular medical device includes a heat therapy assembly and an elongated member coupled to the heat therapy assembly. The heat therapy assembly is configured to expand a vessel beyond an initial size of the vessel and deliver energy to a wall of the expanded vessel to heat the wall of the vessel. The therapeutic medical device is communicatively coupled to the heat therapy assembly and configured to control the heat therapy assembly to deliver the energy to ablate smooth muscle cells of the wall of the vessel and substantially denature one or more structural proteins of the wall of the vessel.

A system includes an intravascular medical device and a therapeutic medical device. The intravascular medical device includes a heat therapy assembly and an elongated member coupled to the heat therapy assembly. The heat therapy assembly is configured to expand a vessel beyond an initial size of the vessel and deliver energy to a wall of the expanded vessel to heat the wall of the vessel. The therapeutic medical device is communicatively coupled to the heat therapy assembly and configured to control the heat therapy assembly to deliver the energy to ablate smooth muscle cells of the wall of the vessel and substantially denature one or more structural proteins of the wall of the vessel.

Systems, methods and devices for the treatment of tissue are disclosed. A system includes an elongate tube with a distal portion. A treatment element is positioned on the elongate tube distal portion, the treatment element constructed and arranged to treat target tissue. In one embodiment, gastrointestinal tissue is modified for the treatment of diabetes.

Systems, methods and devices for the treatment of tissue are disclosed. A system includes an elongate tube with a distal portion. A treatment element is positioned on the elongate tube distal portion, the treatment element constructed and arranged to treat target tissue. In one embodiment, gastrointestinal tissue is modified for the treatment of diabetes.

To provide a chemical ablation device that enables simple performance of chemical ablation treatment including pre- and post-treatment potential measurements. A chemical ablation device according to the present invention includes an electrode-equipped guidewire (30) with which intracardiac potential is measurable, an over-the-wire balloon catheter (40) having a guidewire lumen (415) into which the electrode-equipped guidewire (30) is to be inserted, a Y-shaped connector (50) connected to a proximal side of the balloon catheter (40) and including a guidewire port (51) and an expansion port (53), and a hemostasis valve (60) connected to the guidewire port (51) of the Y-shaped connector (50) and including a side-infusion tube (65) for supplying ethanol to the guidewire lumen (415) of the balloon catheter (40). The ethanol supplied to the guidewire lumen (415) of the balloon catheter (40) is ejected from an opening of a distal tip (47).

To provide a chemical ablation device that enables simple performance of chemical ablation treatment including pre- and post-treatment potential measurements. A chemical ablation device according to the present invention includes an electrode-equipped guidewire (30) with which intracardiac potential is measurable, an over-the-wire balloon catheter (40) having a guidewire lumen (415) into which the electrode-equipped guidewire (30) is to be inserted, a Y-shaped connector (50) connected to a proximal side of the balloon catheter (40) and including a guidewire port (51) and an expansion port (53), and a hemostasis valve (60) connected to the guidewire port (51) of the Y-shaped connector (50) and including a side-infusion tube (65) for supplying ethanol to the guidewire lumen (415) of the balloon catheter (40). The ethanol supplied to the guidewire lumen (415) of the balloon catheter (40) is ejected from an opening of a distal tip (47).

The disclosure describes devices, systems, and techniques for identifying and treating bladder dysfunction. In one example, a method includes identifying one or more focal points at respective locations of bladder tissue of a bladder of a patient, the one or more focal points initiating coordinated contractions of a detrusor muscle. The method may also, or alternatively, include ablating, for each of the one or more focal points, a respective portion of the bladder tissue at the respective location of the focal point. Ablation of these targeted portions of the bladder tissue may reduce the coordinated contractions of the detrusor muscle and alleviate overactive bladder symptoms.