A compound of Formula (II): for use in the prevention or treatment of a bacterial infection.

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Dendrimers with monophosphonic or bisphosphonic terminations for the treatment of inflammatory diseases.

Provided are a manufacturing method for an amino-substituted phosphazene compound including reacting a fluorinated phosphazene compound and an amine compound in presence of a compound having a fluorine trapping function; and synthesizing a compound obtained by substituting the amine compound for the fluorinated phosphazene compound, a manufacturing method for an electrolyte solution for a nonaqueous secondary battery using this, and a manufacturing method for a nonaqueous secondary battery.

The present invention relates to a fluorination method for phosphonitrilic chloride trimer and its derivatives including using phosphonitrilicchloride or partially substituted phosphonitrilic chloride trimer as raw material to fluorinate with fluorinating agent in an ionic liquid to replace the chlorine in chloro-cyclotriphosphazene molecule. The present invention uses non-volatile and pollution free ionic liquids as solvent, and just controls a distillation temperature to get a hexafluorocyclotriphosphazene or derivatives thereof with high-purity. It overcomes the shortcoming of the average solvent system that the solvent forms azeotrope with products. The post-process is simple. The production rate is high, and the ionic liquid can be recycled. The present invention produces products with high purity.

An object of the present invention is to provide a mixture of cyclophosphazenes suitably substituted with phenoxy having a polymerizable functional group, such as allyl, on the phenyl ring and a production method for the mixture. The invention relates to a mixture of cyclophosphazene compounds that each contain a plurality of constituent units linked to each other, each constituent unit being represented by formula (I):

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wherein R.sup.1 and R.sup.2 are identical or different and represent C.sub.1-4 alkyl or the like, the mixture containing cyclophosphazene compounds in which 3, 4, and 5 constituent units represented by formula (I) are linked, wherein the cyclophosphazene compound containing 3 linked constituent units is cyclophosphazene compound (I-A) with a specific structure, compound (I-A) includes cyclophosphazene compounds (I-A2) and (I-A3) having a specific structure, and compounds (I-A2) and (I-A3) are present in an amount of 80 wt % or more in total in cyclophosphazene compound (I-A).

Provided is a resin composition having excellent flame retardance, molding processability, and post-heat aging flame retardance. A flame-retardant resin composition contains: (A) a polyphenylene ether; (B) at least one thermoplastic resin selected from the group consisting of (B-1) a polystyrene resin, (B-2) a polyamide resin, (B-3) a polypropylene resin, and (B-4) a polyphenylene sulfide resin; and (C) a flame retardant. The (A) component has a content of less than 50 mass % when the flame-retardant resin composition minus ash content is taken to be 100 mass %. The flame-retardant resin composition has a flame retardance level of V-0 as measured by a UL 94 vertical burning test. A molded article formed from the flame-retardant resin composition exhibits a rate of change of chloroform-insoluble content of no greater than 15 mass % before and after being subjected to aging in which the molded article is left for 1,000 hours at 150 C. in an atmospheric environment.

A method of manufacturing cyclophosphazenes PFPE derivatives to be used in the lubrication of magnetic recording media is herein provided. The method comprises: a) a (per)fluoropolyether (PFPE) polyol [PFPE (P.sub.pol)] comprising a fluoropolyoxyalkylene chain (R.sub.f) having two chain ends, each chain end comprising at least one hydroxy group, and b) the corresponding alkoxide of perfluoropolyether (P.sub.pol) [PFPE (P.sub.alk)] wherein the equivalent concentration of PFPE (P.sub.alk) in PFPE (P.sub.pol) is lower than 30%, preferably ranging from 5% to 15%; 2) contacting mixture (M) with a perhalocyclophosphazene (CP.sub.halo) to provide a mixture (M1) containing an equivalent ratio of PFPE (P.sub.alk)/(CP.sub.halo) of at least 1; 3) allowing mixture (M1) to react until complete disappearance of PCl groups to provide a mixture (M2); 4) submitting mixture (M2) to hydrolysis to provide a mixture (M3); 5) optionally removing (P.sub.pol) from mixture (M3) to provide a mixture (M4). A method of purifying mixture (M4) is also herein provided.

Provided are compounds of formula (I) which can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. Also provided are pharmaceutical compositions comprising the compounds, methods of preparing the compounds and the use in the manufacture of medicaments for preventing or treating a disease or condition related to p53 mutants.

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The present invention relates to flame-retardant, impact-modified polycarbonate (PC) compositions and molding compositions which have good mechanical properties, good resistance to chemicals and high hydrolytic stability. The present application additionally relates to the use of the compositions in the production of molded articles, and to molded articles produced from the compositions.

Provided are a manufacturing method for an amino-substituted phosphazene compound including reacting a fluorinated phosphazene compound and an amine compound in presence of a compound having a fluorine trapping function; and synthesizing a compound obtained by substituting the amine compound for the fluorinated phosphazene compound, a manufacturing method for an electrolyte solution for a nonaqueous secondary battery using this, and a manufacturing method for a nonaqueous secondary battery.