Process for the preparation of diosmin.

To extract, from plants such as freesia, a novel useful substance which is important in the food/pharmaceutical industry and which is expected to be useful for human health. The present inventors have found that an aromatic compound glycoside, which is a novel substance, is produced in a freesia cultivar having yellow petals such as “Ishikawa f2” in the flower thereof. The inventors have further confirmed that the glycoside exhibits an antioxidant effect, a lipid metabolism-improving effect, and a diabetes-ameliorating effect.

To extract, from plants such as freesia, a novel useful substance which is important in the food/pharmaceutical industry and which is expected to be useful for human health. The present inventors have found that an aromatic compound glycoside, which is a novel substance, is produced in a freesia cultivar having yellow petals such as “Ishikawa f2” in the flower thereof. The inventors have further confirmed that the glycoside exhibits an antioxidant effect, a lipid metabolism-improving effect, and a diabetes-ameliorating effect.

The disclosure relates to methods of forming a dihydrochalcone using electrocatalytic dehydrogenation. In particular, the disclosure relates to methods of forming a dihydrochalcone electrocatalytically hydrogenating (ECH) a reactant compound over a catalytic cathode in a reaction medium having a non-alkaline pH value, thereby forming a dihydrochalcone product; wherein the reactant compound has a structure according to Formula (I). The method can be used to prepare dihydrochalcone sweeteners, such as, for example, naringin dihydrochalcone and neohesperidin dihydrochalcone. ##STR00001##

The disclosure provides a method for separating eighteen components in a traditional Chinese medicine composition, including: (1) preparing the traditional Chinese medicine composition into a total extract of the traditional Chinese medicine composition, separating by resin through sequentially eluting with water, 10% ethanol and 30% ethanol, and collecting the 30% ethanol eluate to obtain a 30% ethanol extract; (2) adding the 30% ethanol extract to a reverse phase silica gel ODS-AQ-HG, and separating in a medium pressure separation column to obtain differently numbered elution dry pastes; (3) dissolving the differently numbered elution dry paste with 30% methanol as a solvent, and passing the solution through a 0.45 μm microporous membrane, carrying out a primary separation by high performance liquid chromatography and collecting chromatographic peaks with different retention times, and further purifying by high performance liquid chromatography; finally obtaining the components of eighteen components.

The present invention relates to a method for preparation of soybean leaves having a high content of an isoflavone derivative in a dark condition and soybean leaves having a high content of an isoflavone derivative prepared thereby. Specifically, treatment of a soybean plant 20 days to 60 days after seeding with a predetermined concentration of ethylene in a dark condition was found to accumulate higher concentrations of isoflavone derivatives in soybean leaves than treatment with ethephon in a light condition, which requires a high level of energy. Therefore, when used, the method of the present invention can economically and quickly prepare soybean leaves having a very high content of isoflavones, and the soybean leaves having a high content of isoflavone derivatives, an extract of the soybean leaves, and a fraction of the extract can be advantageously used as a food and medicine material against diseases caused by estrogen unbalance and deficient antioxidant activity.

Provided herein are analogs of the natural product icariin represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The analogs can be used to modulate (e.g., inhibit, such as by competitive inhibition) PDE5 and thereby treat a wide range of PDE5-mediated diseases, including cardiovascular, gastrointestinal, pulmonary, musculoskeletal, neurological and reproductive diseases. Also provided herein are compositions and methods including compounds of Structural Formula (I).

Provided herein are analogs of the natural product icariin represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The analogs can be used to modulate (e.g., inhibit, such as by competitive inhibition) PDE5 and thereby treat a wide range of PDE5-mediated diseases, including cardiovascular, gastrointestinal, pulmonary, musculoskeletal, neurological and reproductive diseases. Also provided herein are compositions and methods including compounds of Structural Formula (I).

The anthocyanin synthesized from date palm may include co-pigmented anthocyanin complexes synthesized by extracting an anthocyanin from date palm leaves and reacting the anthocyanin with phenolic compounds also resulting from date palm leaf extraction in order to produce a co-pigmented anthocyanin complex. Date palm leaf powder may be mixed with water containing about 1.08% hydrochloric acid in a glass or ceramic lined reactor, and extraction may be performed by boiling the mixture for an hour or more. The color of the co-pigmented anthocyanin complex produced by this method may be adjusted by continuing the heating in half hour increments, in order to deepen the hue of the co-pigmented anthocyanin complex. The co-pigmented anthocyanin complex may be separated from the liquid mixture by first filtering the liquid mixture, refining the liquid mixture by adding gelatin to form a colloidal solution, and freeze-drying the refined liquid mixture.

The disclosure relates to methods of forming a dihydrochalcone using electrocatalytic dehydrogenation. In particular, the disclosure relates to methods of forming a dihydrochalcone electrocatalytically hydrogenating (ECH) a reactant compound over a catalytic cathode in a reaction medium having a non-alkaline pH value, thereby forming a dihydrochalcone product; wherein the reactant compound has a structure according to Formula (I). The method can be used to prepare dihydrochalcone sweeteners, such as, for example, naringin dihydrochalcone and neohesperidin dihydrochalcone.

##STR00001##