Devices, systems and methods for applying a bioadhesive substance to an internal surface of the eye, such as the retina, can include an outer sleeve having a proximal end, a distal end, a passageway extending along a length of the elongate body and an opening at the distal end of the elongate body, an applicator tip including an elongate body having a proximal end and a distal end, an applicator portion coupled with the distal end of the elongate body, and a substance supply lumen extending along a length of the device through which a bioadhesive substance can pass so that the bioadhesive substance can be applied to at least the applicator portion of the applicator tip. Some embodiments of the device can also have a source of the bioadhesive substance in fluid communication with at least the substance supply lumen.

Devices, systems and methods for applying a bioadhesive substance to an internal surface of the eye, such as the retina, can include an outer sleeve having a proximal end, a distal end, a passageway extending along a length of the elongate body and an opening at the distal end of the elongate body, an applicator tip including an elongate body having a proximal end and a distal end, an applicator portion coupled with the distal end of the elongate body, and a substance supply lumen extending along a length of the device through which a bioadhesive substance can pass so that the bioadhesive substance can be applied to at least the applicator portion of the applicator tip. Some embodiments of the device can also have a source of the bioadhesive substance in fluid communication with at least the substance supply lumen.

A laser treatment system includes a laser device configured to produce a laser beam at a wavelength in an ultraviolet spectrum to provide for tissue ablation, a lens configured to focus and direct the laser beam to a site to form an opening in a surface of the site, a valve connected to a first channel, and a nozzle that emits the laser beam and controls delivery of at least a first substance and a second substance to the site. A portion of the first channel is disposed within a first sidewall of the nozzle to deliver the first substance, and a second channel unconnected with the valve is disposed within a second sidewall of the nozzle to deliver the second substance.

A laser treatment system includes a laser device configured to produce a laser beam at a wavelength in an ultraviolet spectrum to provide for tissue ablation, a lens configured to focus and direct the laser beam to a site to form an opening in a surface of the site, a valve connected to a first channel, and a nozzle that emits the laser beam and controls delivery of at least a first substance and a second substance to the site. A portion of the first channel is disposed within a first sidewall of the nozzle to deliver the first substance, and a second channel unconnected with the valve is disposed within a second sidewall of the nozzle to deliver the second substance.

Systems, instruments, and methods for minimally invasive procedures including one or more of fractional resection, fractional lipectomy, fractional skin grafting, and/or fractional scar revision are described. Embodiments include instrumentation comprising a scalpet assembly coupled to a carrier, and the scalpet assembly includes a scalpet array. The scalpet array includes one or more scalpets configured for fractional resection, fractional lipectomy, fractional skin grafting, and/or fractional scar revision. The system includes a vacuum component coupled to the scalpet assembly and configured to evacuate tissue from the a site. The carrier is configured to control application of a rotational force and/or a vacuum force to the scalpet assembly.

A system for endoscopically imaging a first target of a patient, using a light source and a light detector, and for laser-treating a same or different second target of the patient, using a laser source, the system. For example, the system can have at least signal processing circuitry, which can include a target response signal laser-source flashing component detector and a flashing analyzer.

Devices and methods for tissue treatment produce a mechanical stimulation therapy and electromagnetic field therapy. The mechanical stimulation therapy provides stimulation of blood circulation and stimulates treated cells. The electromagnetic field enables thermal treatment of tissue. Combination of both therapies improves soft tissue treatment, mainly connective tissue in the skin area and fat reduction.

A quantum cardiac electrophysiology device comprising an array of consumable half-ferromagnetic active electrodes connected to an array of semiconductor of half-ferromagnetic selector switches over an array of half-ferromagnetic resistors to a neutral charges out of the heart, by casting and/or inking the arrhythmic substrate of an arrhythmia by the electrophysiology quantum entan- glement of said arrhythmic substrate.

Provided herein is a multifunctional aesthetic system including a housing, an electromagnetic array situated in the housing and having a plurality of electromagnetic radiation (EMR) sources, each EMR source configured to generate an EMR beam having a wavelength different than that of an EMR beam generated by another of the EMR sources, a controller in electronic communication with the array to operate two or more of the EMR sources to direct the EMR beam to a treatment area, and a sensor in electronic communication with the controller for providing feedback to the controller based on defined parameters to allow the controller to adjust at least one operating condition of the multifunctional system in response to the feedback.

The invention provides a tip that permits therapeutic electromagnetic energy systems to deliver multiple beams of overlapping, partially overlapping, and non-overlapping electromagnetic energy in the treatment of tissue disorders and conditions. The tip finds use with laser systems, intense pulsed light systems, LED systems, radiofrequency systems, and microwave systems.