A polypeptide compound having a structure shown in formula I, or a stereoisomer, mixture or pharmaceutically acceptable salt thereof Experimental results show that the polypeptide compound can effectively exhibit high agonistic activity to GHSR-1a.

##STR00001##

The invention relates to synthetic peptide amide ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P.sub.450 CYP inhibition and low penetration into the brain. The synthetic peptide amides of the invention conform to the structure:

##STR00001##

The compounds are useful in the prophylaxis and treatment of pain and inflammation associated with a variety of diseases and conditions.

Provided is a production method of a polypeptide in which expressing a polypeptide as a tagged polypeptide is included, the method including expressing the tagged polypeptide from a nucleic acid containing a base sequence encoding a tag consisting of an amino acid sequence set forth in SEQ ID NO: 1, which is arranged immediately after a start codon, and a base sequence encoding a polypeptide that is arranged in-frame downstream of the base sequence encoding the tag,

SEQ ID NO: 1: Val-Lys-Lys-(Xaa)n. (Xaa)n is a chain of n pieces of any amino acids, where n is an integer of 1 to 8, and the amino acids constituting (Xaa)n may be one type of amino acid or two or more types of amino acids.

The present invention relates to the use of peptides, peptoids and/or peptidomimetics capable of self-assembling and forming a (nanofibrous) hydrogel in biofabrication. The present invention further relates to methods for preparing hydrogels and to methods for preparing continuous fibres and to methods for obtaining multi-cellular constructs with defined, precise geometrics. The present invention further relates to various uses of such hydrogels for obtaining mini-hydrogel arrays and 3D organoid structures or 3D macromolecular biological constructs.

Disclosed are a compound-linker conjugate and a class of compounds having the STING activation activity, as well as their applications in the preparation of antibody drug conjugates. The compound-linker conjugate is represented by

##STR00001##

The compounds are represented by

##STR00002##

The compounds are suitable as payloads of the antibody drug conjugates.

The present invention discloses an anti-aging sturgeon roe tetrapeptide, having a peptide sequence of NLPL. The present invention further discloses a preparation method of the anti-aging sturgeon roe tetrapeptide, specifically comprising the following steps: (1) adding deionized water to sturgeon roes and homogenizing to obtain a sturgeon roe homogenate; (2) adjusting a pH value of the sturgeon roe homogenate, adding Alcalase, performing enzymolysis and enzyme inactivation, and cooling to obtain sturgeon roe enzymatic hydrolysate; and (3) centrifuging the sturgeon roe enzymatic hydrolysate, taking a supernatant to obtain anti-aging sturgeon roe tetrapeptide, and storing for later use. The sturgeon roe peptide prepared by the present invention can improve the levels of oxidative stress and skin related factors (type I collagen and hyaluronic acid) by adjusting a cell proliferation state, so as to realize the protective effect on skin cells at a cellular level.

The present invention generally relates to compounds that are useful for inhibiting one or more of hepatocyte growth factor activator, matriptase, hepsin, Factor Xa, or thrombin. The present invention also relates to various methods of using the inhibitor compounds including treating a malignancy, a pre-malignant condition, or cancer by administering an effective amount of the inhibitor to a subject in need thereof.

Provided is a cognitive function-improving composition. Specifically, provided is a cognitive function-improving composition comprising at least one selected from the group consisting of a thermolysin digest of ovalbumin, a peptide comprising amino acid sequence LP, and a peptide comprising amino acid sequence LE.

The present invention discloses an anti-aging sturgeon roe tetrapeptide, having a peptide sequence of NLPL (SEQ ID NO: 9). The present invention further discloses a preparation method of the anti-aging sturgeon roe tetrapeptide, specifically comprising the following steps: (1) adding deionized water to sturgeon roes and homogenizing to obtain a sturgeon roe homogenate; (2) adjusting a pH value of the sturgeon roe homogenate, adding alkaline protease, performing enzymolysis and enzyme inactivation, and cooling to obtain sturgeon roe enzymatic hydrolysate; and (3) centrifuging the sturgeon roe enzymatic hydrolysate, taking a supernatant to obtain anti-aging sturgeon roe tetrapeptide, and storing for later use. The sturgeon roe peptide prepared by the present invention can improve the levels of oxidative stress and skin related factors (type I collagen and hyaluronic acid) by adjusting a cell proliferation state, so as to realize the protective effect on skin cells at a cellular level.

This invention provides isolated and characterized secreted molecules from probiotic bacteria for use in compositions and methods for the treatment and/or prevention of infection by harmful pathogenic bacteria. The isolated secreted molecules can also be used in nutritional or medical food products which provide probiotics to the gastrointestinal tract of a mammal.