Patent classifications
C08B37/0078
Methods and compositions for promoting hair growth
Methods and compositions related to promoting hair growth are described.
High purity heparin and production method therefor
The present invention provides a high purity heparin useful to be a pharmaceutical product, cosmetics, research reagent, or the like, and a method for producing the same, more specifically, a heparin which does not substantially contain a nitrous acid degradation-resistant impurity and a method for producing a heparin, comprising mixing an aqueous solution of 5 to 30% by weight of the heparin with ethanol having an amount (volume) 0.2 to 1 times the amount (volume) of the aqueous heparin solution to obtain a colloidal precipitate of heparin.
SYNTHETIC HEXASACCHARIDES MIMICS OF HEPARIN SHOWING HEPARANASE INHIBITION ACTIVITY
The present invention is directed to hexasaccharides mimetics of heparins presenting remarkable heparanase inhibition activity. The compounds have formula (I), wherein R.sup.1 is selected from the group consisting of NH.sub.2, NHSO.sub.3Na, NHAc; R.sup.2 is selected from the group consisting of NH.sub.2, NHSO.sub.3Na, NHAc; R.sup.3 is selected from the group consisting of Bn, H; R.sup.4 is selected from the group consisting of Ac, H, SO.sub.3Na; R.sup.5 is CO.sub.2Na; R.sup.6 is selected from the group consisting of Me, Ethyl, Alkyl, alkyl azide, alkynyl, cholestanol aglycon; R.sup.7 is selected from the group consisting of CH.sub.2OH, COOH.
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