A polymeric delivery system delivers a biologic to cells. In some embodiments, the polymeric delivery system includes polyplexes. Each polyplex includes at least one charged polymer and at least one biologic. The at least one charged polymer includes a polyester copolymer of a polyol and a polycarboxylic acid modified with at least one charged moiety having an opposite charge from a net charge of the at least one biologic. In other embodiments, the polymeric delivery system includes self-assembled particles including a block copolymer and a biologic associated with the block copolymer. The block copolymer includes a first block of a polyester copolymer of a polyol and a polycarboxylic acid and a second block of a second monomer or a second polymer.

The present disclosure provides for a metal chelated polyol liquid and/or a metal chelated polyether polyol liquid that can be used in an isocyanate-reactive composition and a reaction mixture for forming a polyurethane polymer. The metal chelated polyester polyol liquid is a reaction product of a chelating polyester polyol having a chelating moiety and a metal compound having a metal ion. The metal chelated polyether polyol liquid is a reaction product of a chelating polyether polyol having a chelating moiety and a metal compound having a metal ion. The chelating moiety of the chelating polyester polyol or the chelating polyether polyol chelates the metal ion to form the metal chelated polyester polyol liquid or the metal chelated polyether polyol liquid, respectively, having a mole ratio of the metal ion to the chelating moiety of 0.05:1 to 2:1.

Embodiments of the present disclosure are directed towards solvent-based compositions that include a reaction product formed by reacting a polyol and an aminopolycarboxylic compound.

Polyethylene glycol (PEG)-b-poly(β-amino ester) (PBAE) co-polymers (PEG-PBAE) and blends of PEG-PBAEs and PBAEs and their use for delivering drugs, genes, and other pharmaceutical or therapeutic agents safely and effectively to different sites in the body and to different cells, such as cancer cells, are disclosed.

The present invention is a soluble material for three-dimensional modeling that is used as a material of a support material for supporting a three-dimensional object when the three-dimensional object is manufactured by a 3D printer of a fused deposition modeling system and that contains a thermoplastic resin having a hydrophilic group and an organic salt compound represented by a general formula (I) below: (R.sup.1—SO.sub.3.sup.−).sub.nX.sup.n+ (I). According to the present invention, it is possible to provide a soluble material for three-dimensional modeling that is used for a support material and that is capable of suppressing the degradation of the modeling accuracy of a three-dimensional object when the three-dimensional object is manufactured by a 3D printer of a fused deposition modeling system, and has a high rate of dissolution to neutral water to be removable speedily from a precursor of the three-dimensional object without use of a strong alkaline aqueous solution.

A thermoplastic resin may have a structural unit of formula (1):

##STR00001##

wherein A.sup.1 to A.sup.8 are each independently ═CH— or ═N—, and at least one of A.sup.1 to A.sup.8 is ═N—. R.sup.1 to R.sup.8 are each independently a hydrogen atom, an alkyl group, an aryl group, a heteroaryl group, or the like, and at least two adjacent groups out of R.sup.1 to R.sup.8 may be bonded to each other to form a ring. R.sup.9 and R.sup.10 are each independently a direct bond or an optionally substituted alkylene group having 1 to 20 carbon atoms. X is an oxygen atom, a carbonyl group, or an optionally substituted amino group. And n is an integer of 0 to 5.

A resin composition includes: a resin having a first group capable of forming at least two hydrogen bonds; and a photoisomerization compound having a second group capable of forming at least two hydrogen bonds complementarily with the first group and having a moiety that is reversibly isomerized by light.

The present invention discloses a method for synthesizing an aromatic-aliphatic copolyester without a catalyst and a product thereof. The method includes: a prepolymerization stage: under the condition of not adding a catalyst, subjecting raw materials including an aromatic dicarboxylic acid, a dihydric alcohol and a cyclic dicarboxylic acid or a corresponding anhydride thereof to an esterification reaction to obtain a carboxyl-terminated prepolymer, where the total molar amount of the dicarboxylic acids is greater than the molar amount of the dihydric alcohol; and a polymerization stage: under the condition of reduced pressure, removing the anhydride corresponding to the cyclic dicarboxylic acid from the carboxyl-terminated prepolymer at a reaction temperature not lower than the boiling point of the anhydride corresponding to the cyclic dicarboxylic acid to obtain an aromatic-aliphatic copolyester. According to the method of the present invention, the aromatic-aliphatic copolyester without a catalyst can be prepared, so that the problems of biological toxicity, accelerated aging, shortened storage time and service life and the like caused by a catalyst residue can be avoided. Meanwhile, the aromatic-aliphatic copolyester has degradability, so that the current environmental protection pressure is reduced.

Provided is a laser marking multilayer film that includes: a layer (X) at least as an outermost layer, the layer (X) being made from a resin composition (x) containing a bisphenol-based polycarbonate (A) and a polyester (B), the polyester (B) containing a predetermined compound as a diol component, the resin composition (x) containing the predetermined compound in an amount of 0.1 to 20 mass %; and at least one layer (Y) made from a resin composition (y) containing the bisphenol-based polycarbonate (A) and a laser beam energy absorber (C). The multilayer film does not contaminate equipment such as a T-die and rolls in melt extrusion molding, brings about good laser marking performance. On the multilayer film, laser-marked information does not fade even in long-term use. In the multilayer film, the base material does not deteriorate.

The present invention relates to the technical field of oil and gas drilling, and discloses a biodiesel-based constant rheological property drilling fluid containing intelligent temperature responsive polymer, which contains two or more of the following components which are stored in admixture or separately: base oil biodiesel, aqueous phase, emulsifier, organic soil, constant rheological property flow pattern modifier, hydrolysis inhibitor, filtrate reducer and weighting material; the constant rheological property flow pattern modifier is an intelligent temperature responsive polymer, and the polymer contains structural units provided by bis-hydroxyethyl bis-hydroxypropyl stearyl ammonium chloride, ethylene bis-stearamide and dimerized fatty acid. The drilling fluid provided by the present invention has excellent environmental protection property and degradability, and has conventional rheological property, weak gel structure and fluid loss property which are equivalent to those of the conventional oil-based drilling fluid, and also has excellent temperature resistance, CaO compatibility and constant rheological property.