Phosphate-containing copolymers, medical compositions containing the phosphate-containing copolymers, and methods of suppressing microbial virulence are provided. By suppressing virulence, administration and/or application of the medical compositions can be used to prevent, mitigate, or treat a microbial infection. The phosphate-containing copolymers are prepared by phosphorylating either a random copolymer or a random copolymeric block that contains monomeric units of propylene oxide and glycidol.

The invention provides a process for preparing a mixture (M) which comprises silane-terminated polymers (SP1) of the general formula (I)

Y.sup.1—[O—C(═O)—NH—(CR.sup.1.sub.2).sub.b—SiR.sub.a(OR.sup.2).sub.3-a].sub.x  (I),

optionally silane-terminated polymers (SP2) of the general formula (II)

Y.sup.2—[O—C(═O)—NH—(CR.sup.1.sub.2).sub.b—SiR.sub.a(OR.sup.2).sub.3-a].sub.z  (II) and hydroxy-functional polymers (SP3) of the general formula (III)

Y.sup.2—[O—C(═O)—NH—(CR.sup.1.sub.2).sub.b—SiR.sub.a(OR.sup.2).sub.3-a].sub.z-z1(OH).sub.z1  (III) where Y.sup.1 and Y.sup.2 are polymer radicals and R, R.sup.1, R.sup.2, x, z, z1, a and b have the definitions indicated in claim 1, wherein, in a first process step, at least one polymer (HP1) of the general formula (IV)

Y.sup.1—[OH].sub.x  (IV) reacts with at least one isocyanate-functional silane (S) of the general formula (V)

O═C═N—(CR.sup.1.sub.2).sub.b—SiR.sub.a(OR.sup.2).sub.3-a  (V) to give silane-terminated polymers (SP1), and, in a second process step, the unreacted isocyanate groups of the isocyanate-functional silane (S) of the general formula (V) are reacted with at least one oligomer or polymer (HP2) of the general formula (VI)

Y.sup.2(OH).sub.z  (VI); polymer mixtures (M) preparable by the process; and use of the polymer mixtures (M) for producing adhesives and sealants and also coatings.

The invention provides a process for preparing a mixture (M) which comprises silane-terminated polymers (SP1) of the general formula (I)

Y.sup.1—[O—C(═O)—NH—(CR.sup.1.sub.2).sub.b—SiR.sub.a(OR.sup.2).sub.3-a].sub.x  (I),

optionally silane-terminated polymers (SP2) of the general formula (II)

Y.sup.2—[O—C(═O)—NH—(CR.sup.1.sub.2).sub.b—SiR.sub.a(OR.sup.2).sub.3-a].sub.z  (II) and hydroxy-functional polymers (SP3) of the general formula (III)

Y.sup.2—[O—C(═O)—NH—(CR.sup.1.sub.2).sub.b—SiR.sub.a(OR.sup.2).sub.3-a].sub.z-z1(OH).sub.z1  (III) where Y.sup.1 and Y.sup.2 are polymer radicals and R, R.sup.1, R.sup.2, x, z, z1, a and b have the definitions indicated in claim 1, wherein, in a first process step, at least one polymer (HP1) of the general formula (IV)

Y.sup.1—[OH].sub.x  (IV) reacts with at least one isocyanate-functional silane (S) of the general formula (V)

O═C═N—(CR.sup.1.sub.2).sub.b—SiR.sub.a(OR.sup.2).sub.3-a  (V) to give silane-terminated polymers (SP1), and, in a second process step, the unreacted isocyanate groups of the isocyanate-functional silane (S) of the general formula (V) are reacted with at least one oligomer or polymer (HP2) of the general formula (VI)

Y.sup.2(OH).sub.z  (VI); polymer mixtures (M) preparable by the process; and use of the polymer mixtures (M) for producing adhesives and sealants and also coatings.

Provided herein according to some embodiments is a dual cure additive manufacturing resin, comprising: (i) a light polymerizable component, (ii) a photoinitiator, (iii) a heat polymerizable component, and (iv) a non-reactive diluent, which resin is useful for the production of three-dimensional objects by additive manufacturing. Methods of using the same are also provided.

Provided herein according to some embodiments is a dual cure additive manufacturing resin, comprising: (i) a light polymerizable component, (ii) a photoinitiator, (iii) a heat polymerizable component, and (iv) a non-reactive diluent, which resin is useful for the production of three-dimensional objects by additive manufacturing. Methods of using the same are also provided.

A first embodiment of a method for producing water-absorbent resin particles includes a polymerization step of polymerizing a monomer on at least a part of a surface of a surface-crosslinked polymer particle to obtain a polymer. A second embodiment of a method for producing water-absorbent resin particles includes a polymerization step of polymerizing a monomer on at least a part of a surface of a non-surface-crosslinked polymer particle in the presence of a crosslinking agent to obtain a polymer.

A vesicle incorporate a transmembrane protein, the vesicle forming material including a mixture of poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) and polyetheramine. The vesicle can generally withstand elevated temperature without substantial shrinkage of the diameter, which in turn results in maintenance of the water permeability virtually unaffected. Pluronic based vesicles have a large content of amino groups available on the surface illustrated by the larger zeta potential values available for crosslinking in the polyamide layer by chemical reaction with trimesoyl chloride (TMC).

A vesicle incorporate a transmembrane protein, the vesicle forming material including a mixture of poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) and polyetheramine. The vesicle can generally withstand elevated temperature without substantial shrinkage of the diameter, which in turn results in maintenance of the water permeability virtually unaffected. Pluronic based vesicles have a large content of amino groups available on the surface illustrated by the larger zeta potential values available for crosslinking in the polyamide layer by chemical reaction with trimesoyl chloride (TMC).

The presently disclosed and/or claimed inventive concept(s) relates to a method for preparing a reaction product, comprising (1) molten mixing a first active hydrogen containing component and a first alkali hydroxide to form a first mixture; (2) adding water into the first mixture to dissolve the first molten alkali hydroxide to form a second mixture; (3) reacting a first hydrophobic component with the second mixture to provide a Diluent; (4) molten mixing at least one second active hydrogen containing component, a second alkali hydroxide and the Diluent to form a third mixture; (5) adding water into the third mixture to dissolve the second molten alkali hydroxide to form a fourth mixture; and (6) reacting the fourth mixture with a gem-polyhalide compound or a sulfonate ester for a sufficient time to form the reaction product. Also, disclosed is a water soluble or dispersible composition comprising; a diluent and a polymer

The presently disclosed and/or claimed inventive concept(s) relates to a method for preparing a reaction product, comprising (1) molten mixing a first active hydrogen containing component and a first alkali hydroxide to form a first mixture; (2) adding water into the first mixture to dissolve the first molten alkali hydroxide to form a second mixture; (3) reacting a first hydrophobic component with the second mixture to provide a Diluent; (4) molten mixing at least one second active hydrogen containing component, a second alkali hydroxide and the Diluent to form a third mixture; (5) adding water into the third mixture to dissolve the second molten alkali hydroxide to form a fourth mixture; and (6) reacting the fourth mixture with a gem-polyhalide compound or a sulfonate ester for a sufficient time to form the reaction product. Also, disclosed is a water soluble or dispersible composition comprising; a diluent and a polymer