Processes for preparing a polymer polyol (PMPO) in which a base polyol is continuously produced in a continuous base polyol reactor, the base polyol is continuously discharged from the continuous base polyol reactor; the base polyol is continuously introduced to a continuous PMPO reactor, which is different from the continuous base polyol reactor, and PMPO is continuously removed from the PMPO reactor. Production plant configured to carry out such processes are also described.

Provided herein are polymeric -hydroxy aldehyde or -hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the -carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol.

A polymer (A) having, at one terminal moiety thereof, a terminal structure having two or more carbon-carbon unsaturated bonds. A reactive-silicon-group-containing polymer (B) having, at one terminal moiety thereof, a terminal structure having two or more reactive silicon groups.

Disclosed are compositions that comprise water and a polyether polyol derived from sucrose and an alkylene oxide, as well as polyurethane foam systems comprising such compositions, methods for their production, and the resulting polyurethane foams.

This invention relates to novel double metal cyanide catalysts and to a process for the production of these double metal cyanide catalysts. These DMC catalysts can be used to prepare polyoxyalkylene polyols which have low amounts of high molecular weight tail compared polyoxyalkylene polyols prepared from DMC catalysts of the prior art.

A polyol block copolymer comprising a polycarbonate block, A (-A-ZZ(Z-A).sub.n-), and polyethercarbonate blocks, B. The polyol block copolymer has the polyblock structure:
B-A-ZZ(Z-A-B).sub.n
wherein n=t1 and wherein t=the number of terminal OH group residues on the block A; and wherein each A is independently a polycarbonate chain having at least 70% carbonate linkages, and wherein each B is independently a polyethercarbonate chain having 50-99% ether linkages and at least 1% carbonate linkages; and wherein ZZ(Z).sub.n is a starter residue. A process of producing a polyol block copolymer from a two step process carried out in two reactors, and products and compositions incorporating such copolymers.

The present invention discloses a non-linear PEGylated lipid, including the structure represented by the Formula (1); wherein, B.sub.1 and B.sub.2 are linking bonds or alkylene groups; L.sub.1 and L.sub.2 are linking bonds or divalent linking groups; L.sub.x, Y, and L.sub.d are divalent linking groups; R.sub.1 and R.sub.2 are C.sub.4-50 hydrocarbon groups or C.sub.4-50 residues of hydrocarbon derivative containing 1-4 heteroatoms; X is CH< or

##STR00001##

n.sub.1, n.sub.2, and n.sub.3 are integers in the range of 4-250; T is a terminal group. Compared with linear PEGylated lipids, the non-linear PEGylated lipid provided herein can realize better protective effects toward the modified LNPs. The lipid pharmaceutical composition of the present invention exhibits high efficiency of drug encapsulation, appropriate particle size, non-toxicity, and good stability in serum. The LNP-nucleic acid pharmaceutical composition of the present invention demonstrates an excellent ability to complex with nucleic acids and shows high transfection activity.

##STR00002##

A process for producing a polyol block copolymer in a multiple reactor system including a first and second reactor in which a first reaction takes place in the first reactor and a second reaction takes place in the second reactor. The first reaction is the reaction of a carbonate catalyst with CO.sub.2 and epoxide, in the presence of starter and/or solvent to produce polycarbonate polyol copolymer and the second reaction is the reaction of DMC catalyst with the polycarbonate polyol compound of the first reaction and epoxide to produce polyol block copolymer. The product of the first reaction is fed into the second as crude reaction mixture, the epoxide and the polycarbonate polyol compound of the first reaction are fed in a continuous or semi-batch manner, and/or the product of the first reaction has neutral or alkaline pH on addition to the second. The invention further relates to the copolymers and products incorporating such copolymers.

The invention relates to a process for preparing a polyoxyalkylene carbonate polyol by reacting a polyoxyalkylene polyol with a cyclic carbonate in the presence of an amine catalyst. The invention further relates to polyoxyalkylene carbonate polyols obtainable using the method according to the invention and to a process for preparing polyurethanes by reacting the polyoxyalkylene carbonate polyols according to the invention with polyisocyanates.

A polyol block copolymer including a polycarbonate block, A(AZZ(ZA).sub.n), and polyethercarbonate blocks, B. The polyol block copolymer has the polyblock structure:

##STR00001##

wherein n=t1 and wherein t=the number of terminal OH group residues on the block A; and wherein each A is independently a polycarbonate chain having at least 70% carbonate linkages, and wherein each B is independently a polyethercarbonate chain having 50-99% ether linkages and at least 1% carbonate linkages; and wherein ZZ(Z).sub.n is a starter residue. The process of producing a polyol block copolymer from a two step process carried out in two reactors, and products and compositions incorporating such copolymers.