The present invention relates to a technique for effective intranasal delivery to the brain. More specifically, the present invention is used for diagnosing, preventing or treating central nervous system encephalopathy, neurodegenerative diseases or brain tumor by effectively delivering to the brain a pH-responsive and bioreducible PPA polymer, which can be used as a drug carrier, by means of nasal administration.

The present disclosure relates to degradable polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and have backbones which are capable of undergoing degradation in vivo. In some aspects, the disclosure also provides methods of using these degradable polymers for the delivery of a drug.

A multi-arm, degradable polyethylene glycol derivative with a high molecular weight that does not cause vacuolation of cells is provided. A degradable polyethylene glycol derivative represented by the following formula (1):

##STR00001##

wherein n1 and n2 are each independently 45-950, W.sup.1 and W.sup.2 are each independently an oligopeptide of 2-47 residues, a1 and a2 are each independently 1-8, Q is a hydrocarbon chain having 2-12 carbon atoms and optionally containing an oxygen atom and/or a nitrogen atom, X.sup.1 and X.sup.2 are each independently a functional group capable of reacting with a bio-related substance, and L.sup.1, L.sup.2, L.sup.3, L.sup.4, L.sup.5 and L.sup.6 are each independently a divalent spacer.

A multi-arm, degradable polyethylene glycol derivative with a high molecular weight that does not cause vacuolation of cells is provided. A degradable polyethylene glycol derivative represented by the following formula (1):

##STR00001##

wherein n1 and n2 are each independently 45-950, W.sup.1 and W.sup.2 are each independently an oligopeptide of 2-47 residues, a1 and a2 are each independently 1-8, Q is a hydrocarbon chain having 2-12 carbon atoms and optionally containing an oxygen atom and/or a nitrogen atom, X.sup.1 and X.sup.2 are each independently a functional group capable of reacting with a bio-related substance, and L.sup.1, L.sup.2, L.sup.3, L.sup.4, L.sup.5 and L.sup.6 are each independently a divalent spacer.

A lubricant for a magnetic recording medium capable of forming a lubricant layer having excellent adhesion to a protective layer is provided. A lubricant for a magnetic recording medium contains a fluorine-containing ether compound in which a group having an ethylenic carbon-carbon double bond is disposed at one or both terminals of a perfluoroalkyl polyether chain. It is preferable that the group having the ethylenic carbon-carbon double bond is disposed at one terminal of the perfluoroalkyl polyether chain, and a hydroxyl group is disposed at other terminal. It is preferable that the lubricant for a magnetic recording medium contains a compound in which one or more functional groups selected from a hydroxyl group, an amino group, an amido group and a carboxyl group is disposed at one or both terminals of a perfluoroalkyl polyether chain.

A lubricant for a magnetic recording medium capable of forming a lubricant layer having excellent adhesion to a protective layer is provided. A lubricant for a magnetic recording medium contains a fluorine-containing ether compound in which a group having an ethylenic carbon-carbon double bond is disposed at one or both terminals of a perfluoroalkyl polyether chain. It is preferable that the group having the ethylenic carbon-carbon double bond is disposed at one terminal of the perfluoroalkyl polyether chain, and a hydroxyl group is disposed at other terminal. It is preferable that the lubricant for a magnetic recording medium contains a compound in which one or more functional groups selected from a hydroxyl group, an amino group, an amido group and a carboxyl group is disposed at one or both terminals of a perfluoroalkyl polyether chain.

The present disclosure provides amphiphilic fluorinated surfactant molecules for lowering the surface tension of aqueous, hydrocarbon, or solid phases in the presence of a fluorophilic continuous phase and for selectively interacting with biological and/or chemical molecules.

Polyurethane foams are made by curing a reaction mixture that contains an aromatic polyisocyanate, at least one isocyanate-reactive material having an average functionality of at least 2 and an equivalent weight of at least 200 per isocyanate-reactive group, at least one blowing agent, at least one surfactant and at least one catalyst, and a certain 3-oxopropanamide compound. Foams so produced emit low levels of aldehydes.

The present invention relates to a composition comprising a mixture of a first and a second hydrophobically modified alkylene oxide polymer, wherein the first hydrophobically modified alkylene oxide polymer is endcapped with at least one first hydrophobic group functionalized with a secondary amine or a salt thereof, or a tertiary amine or a salt thereof;

and wherein the second hydrophobically modified alkylene oxide polymer is endcapped with at least one second hydrophobic group, structure I:

##STR00001##

where R.sup.1, R.sup.2, m, and n are as defined herein. The present invention also relates to a method for preparing the composition. The composition of the present invention provides an associative thickener with an excellent balance of as-is viscosity and temperature stability over a wide temperature range.

A branched type hetero monodispersed polyethylene glycol represented by formula (1) ##STR00001##
where X.sup.1, Y.sup.1, n, E, L.sup.1, L.sup.2 and L.sup.3 are as defined herein.