A polymer electrolyte is provided, which includes a polymer including an ethylene oxide unit; and a lithium salt, wherein the terminal of the polymer is substituted with one to four functional groups selected from the group consisting of a nitrogen compound functional group and phosphorus compound functional group, and the terminal of the polymer and the one to four functional groups are linked by one selected from the group consisting of a C2 to C20 alkylene linker, a C2 to C20 ether linker, and a C2 to C20 amine linker. A method for preparing the same is also provided.

Provided herein are polymers obtainable by a process including the steps a) and b) described below. In Step a) at least one component a1) is condensed to obtain a polyether having remaining hydroxyl groups. Component a1) is at least one component selected from N-(hydroxyalkyl) amins according to formula (Ia) and/or (Ib) as defined below. Besides component a1), further components can be present in the condensation step a). In step b) a part of the remaining hydroxyl groups are reacted with at least one alkylene oxide. The alkoxylation according to step b) is carried out in a substoichiometric way. The ratio of i) the alkylene oxide versus ii) the sum of the amount of the remaining hydroxyl groups is >0:1 to <1:1 [mol/mol]. Further provided herein is a process for preparing such polymers and derivatives of the polymers by quaternization, protonation, sulphation and/or phosphation.

Provided herein are polymers obtainable by a process including the steps a) and b) described below. In Step a) at least one component a1) is condensed to obtain a polyether having remaining hydroxyl groups. Component a1) is at least one component selected from N-(hydroxyalkyl) amins according to formula (Ia) and/or (Ib) as defined below. Besides component a1), further components can be present in the condensation step a). In step b) a part of the remaining hydroxyl groups are reacted with at least one alkylene oxide. The alkoxylation according to step b) is carried out in a substoichiometric way. The ratio of i) the alkylene oxide versus ii) the sum of the amount of the remaining hydroxyl groups is >0:1 to <1:1 [mol/mol]. Further provided herein is a process for preparing such polymers and derivatives of the polymers by quaternization, protonation, sulphation and/or phosphation.

A compound is provided which is effectively adsorbed to a substrate surface, such as an immune reaction vessel, has extremely high protein adsorption inhibitory effect that inhibits non-specific adsorption of protein or the like, and has excellent washability to retain the inhibitory effect before and after washing operation of the substrate. Also provided are a protein adsorption inhibitor using the compound, a phosphorylcholine-modified substrate, and a method for inhibiting protein adsorption. The compound is a phosphorylcholine group-containing polyethylene glycol derivative represented by formula (1). The method for inhibiting protein adsorption of the present invention includes the step of forming an adsorbed layer of the derivative on a substrate surface.

##STR00001##

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

A lipid derivative in which a hydrophilic polymer is bound through a cyclic benzylidene acetal linker, and which can accurately control a hydrolysis rate in the weakly acidic environment of a living body to detach the hydrophilic polymer from a lipid membrane structure. The lipid derivative is represented by formula (1): ##STR00001##
wherein, R.sup.1 and R.sup.6 are each independently a hydrogen atom or a hydrocarbon group; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; R.sup.7 is a hydrocarbon group having from 8 to 24 carbon atoms, an acyl group having from 8 to 24 carbon atoms, a cholesterol derivative, a glycerolipid, a phospholipid or a sphingolipid; P is a hydrophilic polymer; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; and Z.sup.1 and Z.sup.2 are each independently a selected divalent spacer.

The present disclosure is drawn to a polymeric photo active agent which includes diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide modified with a polyether having from 2 to 200 ether groups.

A polymer electrolyte is provided, which includes a polymer including an ethylene oxide unit; and a lithium salt, wherein the terminal of the polymer is substituted with one to four functional groups selected from the group consisting of a nitrogen compound functional group and phosphorus compound functional group, and the terminal of the polymer and the one to four functional groups are linked by one selected from the group consisting of a C2 to C20 alkylene linker, a C2 to C20 ether linker, and a C2 to C20 amine linker. A method for preparing the same is also provided.

The present invention provides a method for preparing a polymer and a use of the polymer. The resulting polymer is used as a dispersant for an aqueous dispersion of a hydraulic binder and/or a latent hydraulic binder, such that water-reducing rate is improved, and suitable control of air content can be achieved, thereby improving the strength of concrete. The method for preparing a polymer includes polycondensation of a polyether macromonomer A of a specific structure, a monomer B and an aldehyde C to obtain the polymer. The monomer B is phenylsulfonic acid, p-/o-aminophenylsulfonic acid, p-/o-hydroxylbenzoic acid, p-/o-aminobenzoic acid, p-/o-hydroxylphenylsulfonic acid, or a phosphoric acid group or phosphorous acid group-containing monomer of a specific structure. A molar ratio of the polyether macromonomer A and the monomer B is 1:(0.5 to 12).

The present invention provides a method for preparing a polymer and a use of the polymer. The resulting polymer is used as a dispersant for an aqueous dispersion of a hydraulic binder and/or a latent hydraulic binder, such that water-reducing rate is improved, and suitable control of air content can be achieved, thereby improving the strength of concrete. The method for preparing a polymer includes polycondensation of a polyether macromonomer A of a specific structure, a monomer B and an aldehyde C to obtain the polymer. The monomer B is phenylsulfonic acid, p-/o-aminophenylsulfonic acid, p-/o-hydroxylbenzoic acid, p-/o-aminobenzoic acid, p-/o-hydroxylphenylsulfonic acid, or a phosphoric acid group or phosphorous acid group-containing monomer of a specific structure. A molar ratio of the polyether macromonomer A and the monomer B is 1:(0.5 to 12).