A curable composition including a silicone copolymer, a fluoropolyether group-containing compound, and a matrix-forming composition, wherein the silicone copolymer has two or more crosslinkable groups; and the crosslinkable group is a group containing a carbon-carbon double bond, a carbon-carbon triple bond, a cyclic ether group, a hydroxyl group, a thiol group, an amino group, an azide group, a nitrogen-containing heterocyclic group, an isocyanate group, a halogen atom, a phosphoric acid-containing group, or a silane coupling group, or a precursor group thereof. Also disclosed is a film formed from the curable composition, and an article including a substrate and a layer on a surface of the substrate formed from the curable composition.

A silicone copolymer represented by formula (1) or (2) and as defined herein:

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Particles are prepared in an emulsion using a method that includes providing a first reactant having at least two unsaturated carbon-carbon moieties and a second reactant having at least two Si—H moieties, so long as at least one of the unsaturated carbon-carbon moieties of the first reactant or the Si—H moieties of the second reactant is pendant. The method also includes providing a third reactant having a silicon atom and a condensable reactive group bonded to the silicon atom and also having an unsaturated carbon-carbon moiety and/or a Si—H moiety, providing a hydrosilylation catalyst, and providing a polar liquid. The method further includes combining the first, second, and third reactants to form particles that have a cross-linked network wherein the condensable reactive group is disposed on the particles, and adding a silane having an organic moiety and a condensation leaving group to form the particles.

Particles are prepared in an emulsion using a method that includes providing a first reactant having at least two unsaturated carbon-carbon moieties and a second reactant having at least two Si—H moieties, so long as at least one of the unsaturated carbon-carbon moieties of the first reactant or the Si—H moieties of the second reactant is pendant. The method also includes providing a third reactant having a silicon atom and a condensable reactive group bonded to the silicon atom and also having an unsaturated carbon-carbon moiety and/or a Si—H moiety, providing a hydrosilylation catalyst, and providing a polar liquid. The method further includes combining the first, second, and third reactants to form particles that have a cross-linked network wherein the condensable reactive group is disposed on the particles, and adding a silane having an organic moiety and a condensation leaving group to form the particles.

The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C.sub.4-C.sub.40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C.sub.4-C.sub.40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

The present technology provides a nanoparticle that includes a silica network comprising crosslinked polysiloxanes, wherein the crosslinks comprise disulfide linkages, and the nanoparticle has a surface bearing charged functional groups and a surface potential of either less than −30 mV or greater than +30 mV, and wherein the nanoparticle has an average diameter of 20 nm to 60 n. The nanoparticles may be used to efficiently deliver biomolecules to plant cells, including polynucleic acids, proteins and complexes thereof (e.g., Cas9 RNP).

The present technology provides a nanoparticle that includes a silica network comprising crosslinked polysiloxanes, wherein the crosslinks comprise disulfide linkages, and the nanoparticle has a surface bearing charged functional groups and a surface potential of either less than −30 mV or greater than +30 mV, and wherein the nanoparticle has an average diameter of 20 nm to 60 n. The nanoparticles may be used to efficiently deliver biomolecules to plant cells, including polynucleic acids, proteins and complexes thereof (e.g., Cas9 RNP).

This invention relates to medical, health care and non-medical devices comprising a rubbery or elastomeric polymer material taking up more than 5% by weight of water and at most 500% by weight of water after immersion in demineralized water at room temperature for a sufficient time to reach saturation. The material may be in the form of a foam, or in the form of a coating adapted for adhesion to a substrate, or in the form of a sheet, or in the form of a fiber, and may comprise: —repeating units from one or more hydrophobic organic monomers, and —repeating units from one or more monomers (a) being modified with one or more hydrophilic side groups.

This invention relates to medical, health care and non-medical devices comprising a rubbery or elastomeric polymer material taking up more than 5% by weight of water and at most 500% by weight of water after immersion in demineralized water at room temperature for a sufficient time to reach saturation. The material may be in the form of a foam, or in the form of a coating adapted for adhesion to a substrate, or in the form of a sheet, or in the form of a fiber, and may comprise: —repeating units from one or more hydrophobic organic monomers, and —repeating units from one or more monomers (a) being modified with one or more hydrophilic side groups.