Polycaprolactone (PCL) scaffolds having macropores interconnected with micorpores are provided. Tissue grafts that include the PCL scaffold having therapeutic cells encapsulated within the macropores are also provided. Also provided are methods of making the PCL scaffold and the tissue graft, and methods of transplanting cells into an individual using the tissue graft.

Implantable devices for orthopedic, including spine and other uses are formed of porous reinforced polymer scaffolds. Scaffolds include a thermoplastic polymer forming a porous matrix that has continuously interconnected pores. The porosity and the size of the pores within the scaffold are selectively formed during synthesis of the composite material, and the composite material includes a plurality of reinforcement particles integrally formed within and embedded in the matrix and exposed on the pore surfaces. The reinforcement particles provide one or more of reinforcement, bioactivity, or bioresorption.

A method for making a polymer with a porous layer from a solid piece of polymer is disclosed. In various embodiments, the method includes heating a surface of a solid piece of polymer to a processing temperature and holding the processing temperature while displacing a porogen layer through the surface of the polymer to create a matrix layer of the solid polymer body comprising the polymer and the porogen layer. In at least one embodiment, the method also includes removing at least a portion of the layer of porogen from the matrix layer to create a porous layer of the solid piece of polymer.

The disclosure is related to compositions having water permeability greater than about 20 g/(hr*m.sup.2) that includes one or more elastomers and one or more agents and methods of preparing the same. The compositions are suitable for use in acoustical devices such as earpieces, e.g., in-ear earpieces.

A method may comprise: sintering a particulate mixture comprising binder particles at about 5% to about 75% by weight of the particulate mixture and fugitive particles at about 25% to about 90% by weight of the particulate mixture, thereby forming a porous mass; and substantially removing the fugitive particles from the porous mass, thereby forming an ultra-low pressure drop (ULPD) porous mass with fugitive particles at 0% to about 5% by weight of the ULPD porous mass.

A foam composition that includes a polymer material such as polyurethane or polyurea and a leachable water-soluble fine powder is provided. This composition can be used in a relatively simple process to obtain a foam body (porous body) that is uniform only at the surface or uniform throughout. The foam body can be suitably used as a golf ball member in golf balls required to have good controllability on approach shots. Also provided is a method for producing a foam member, which method includes the steps of molding the foam composition to obtain a solid molded body, and then leaching out and removing the water-soluble fine powder so as to obtain a foam-molded body.

A method for making a polymer with a porous layer from a solid piece of polymer is disclosed. In various embodiments, the method includes heating a surface of a solid piece of polymer to a processing temperature and holding the processing temperature while displacing a porogen layer through the surface of the polymer to create a matrix layer of the solid polymer body comprising the polymer and the porogen layer. In at least one embodiment, the method also includes removing at least a portion of the layer of porogen from the matrix layer to create a porous layer of the solid piece of polymer.

A method for making a polymer with a porous layer from a solid piece of polymer is disclosed. In various embodiments, the method includes heating a surface of a solid piece of polymer to a processing temperature and holding the processing temperature while displacing a porogen layer through the surface of the polymer to create a matrix layer of the solid polymer body comprising the polymer and the porogen layer. In at least one embodiment, the method also includes removing at least a portion of the layer of porogen from the matrix layer to create a porous layer of the solid piece of polymer.

A material composition including a matrix including a first material, the matrix including a plurality of voids disposed in the matrix, two or more voids being spaced apart from each other, a plurality of elongate fibers of a second material located within the matrix, wherein the plurality of fibers are configured to reinforce the matrix and, wherein the material composition is a composite material composition.

Embodiments herein described provide devices for identifying and collecting rare cells or cells which occur at low frequency in the body of a subject, such as, antigen-specific cells or disease-specific cells. More specifically, the devices are useful for trapping immune cells and the devices contain a physiologically-compatible porous polymer scaffold, a plurality of antigens, and an immune cell-recruiting agent, wherein the plurality of antigens and the immune cell recruiting agent attract and trap the immune cell in the device. Also provided are pharmaceutical compositions, kits, and packages containing such devices. Additional embodiments relate to methods for making the devices, compositions, and kits/packages. Further embodiments relate to methods for using the devices, compositions, and/or kits in the diagnosis or therapy of diseases such as autoimmune diseases or cancers.