Disclosed is a dissolvable, gel-forming film, and methods for its use, comprising a water-soluble cellulose ether, a hydrophilic rheological modifying agent, and an active proteolytic enzyme or other drug substance. The gel-forming film has a water content of less than 15% w/w and is capable of forming a hydrogel when contacted with water or other aqueous medium. The disclosed films achieve delivery of stable proteolytic enzymes to the desired site of action in a manner that provides uniform delivery of the enzymes.

The present invention provides a method for producing resin beads which can provide various types of products, such as cosmetics, imparted with superior tactile impression, spreadability on the skin, transparency, and product stability, and which can be substituted for resin particles composed of a synthetic material derived from petroleum. The method is a method for producing resin beads containing a cellulose derivative as a main component. The production method includes: a suspension preparation step of mixing an oil phase containing the cellulose derivative and an organic solvent that dissolves the cellulose derivative, the organic solvent having a water-solubility of 0.1 to 50.0 g, and an aqueous phase containing a dispersion stabilizer, thereby preparing a suspension containing oil droplets containing the cellulose derivative and the organic solvent; and an oil droplet contraction step of adding water to the suspension, thereby contracting the oil droplets, wherein the water is added to the suspension in such a way as to satisfy the following expression (A) until a content of the organic solvent in the suspension becomes equal to or less than the water-solubility of the organic solvent.

(W/S)/T≤1.00  (A), wherein

W: an addition amount of water (parts by mass),

S: an amount of the suspension (parts by mass), and

T: a time (minutes) required for addition.

The present invention provides a method for producing resin beads which can provide various types of products, such as cosmetics, imparted with superior tactile impression, spreadability on the skin, transparency, and product stability, and which can be substituted for resin particles composed of a synthetic material derived from petroleum. The method is a method for producing resin beads containing a cellulose derivative as a main component. The production method includes: a suspension preparation step of mixing an oil phase containing the cellulose derivative and an organic solvent that dissolves the cellulose derivative, the organic solvent having a water-solubility of 0.1 to 50.0 g, and an aqueous phase containing a dispersion stabilizer, thereby preparing a suspension containing oil droplets containing the cellulose derivative and the organic solvent; and an oil droplet contraction step of adding water to the suspension, thereby contracting the oil droplets, wherein the water is added to the suspension in such a way as to satisfy the following expression (A) until a content of the organic solvent in the suspension becomes equal to or less than the water-solubility of the organic solvent.

(W/S)/T≤1.00  (A), wherein

W: an addition amount of water (parts by mass),

S: an amount of the suspension (parts by mass), and

T: a time (minutes) required for addition.

Disclosed are endodontic filling materials and methods. A method for filling a dental root canal may include providing a hydrosetting filling material and inserting the hydrosetting filling material into the dental root canal, the material setting in the root canal to form a biocompatible filling. The hydrosetting filling material comprises a hydrogel former and a filler. The hydrogel former is at least one of a reactive organic hydrogel formers, an inorganic hydrogel formers, and a non-reactive organic hydrogel formers, and the filler is at least one of a self-hardening and a non-hardening filler. Plural filling material precursor compositions that collectively contain hydrogel formers and fillers may be provided.

Disclosed are endodontic filling materials and methods. A method for filling a dental root canal may include providing a hydrosetting filling material and inserting the hydrosetting filling material into the dental root canal, the material setting in the root canal to form a biocompatible filling. The hydrosetting filling material comprises a hydrogel former and a filler. The hydrogel former is at least one of a reactive organic hydrogel formers, an inorganic hydrogel formers, and a non-reactive organic hydrogel formers, and the filler is at least one of a self-hardening and a non-hardening filler. Plural filling material precursor compositions that collectively contain hydrogel formers and fillers may be provided.

Hydroxypropyl methyl cellulose having a high thermal gel strength even at a low viscosity is provided and utilized. Specifically provided is hydroxypropyl methyl cellulose having such properties that a 2% by weight aqueous solution of the hydroxypropyl methyl cellulose has a viscosity at 20° C. of 300 to 2,000 mPa.Math.s and a storage elastic modulus at 85° C. of 2,000 to 4,500 mPa. Also provided is a food comprising the hydroxypropyl methyl cellulose. Further provided is a method for producing the hydroxypropyl methyl cellulose, the method comprising a step of depolymerizing, with an acid, high-viscosity hydroxypropyl methyl cellulose having such a property that a 2% by weight aqueous solution of the high-viscosity hydroxypropyl methyl cellulose has a viscosity at 20° C. of 70,000 to 100,000 mPa.Math.s to obtain the hydroxypropyl methyl cellulose.

A filler compound containing a positively charged polymer that includes (meth)acrylate monomer units having an alkylammonium functionality.

A liquid composition comprises an organic diluent and at least one cellulose ether having anhydroglucose units joined by 1-4 linkages and having methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that hydroxyl groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.29 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group. The liquid composition can be used for preparing a solid dispersion of an active ingredient in a cellulose ether.

The present invention pertains to a process for manufacturing a vinylidene fluoride polymer, to a polymer obtainable via said process and to an article comprising the same.

Disclosed are microcapsule compositions having a microcapsule that contains a microcapsule core and a microcapsule shell encapsulating the microcapsule core. The microcapsule has a particle size of 1 micron to 100 microns in diameter. The microcapsule core contains an active material. The microcapsule shell is formed of at least three moieties, in which a first moiety is derived from a polygalactomannan, a second moiety is derived from a polyisocyanate, and a third moiety is derived from a multi-functional aldehyde or a tannic acid.