An image capturing and illumination system comprises a headband, a camera head mounted on the headband and having a camera lens defining a focal point, and a fiber-optic lens assembly for transmitting light therefrom. The fiber-optic lens assembly includes a pair of laterally spaced-apart lenses flanked on opposite sides of the camera lens for directing beams of light toward the focal point.

An illuminated microsurgical instrument comprises a distally projecting tubular member arranged to perform a medical procedure at an interventional site, a sheath member surrounding a portion of the tubular member, and an optical fiber extending along a length of the outer surface of the tubular member between the tubular member and the sheath member. A method of manufacturing an illuminated microsurgical instrument comprises placing an optical fiber on a positioning member, placing a sheath member around the optical fiber and positioning member and securing the sheath member to the optical fiber, removing material from a distal end of the sheath member and optical fiber at a non-perpendicular angle with respect to a longitudinal axis of the positioning member, removing the positioning member from within the sheath member, and placing the sheath member with the optical fiber secured thereto around a distally projecting tubular member.

Certain aspects relate to systems and techniques for articulating medical instruments. In one aspect, the instrument includes a wrist having at least two degrees of freedom of movement, and an end effector coupled to the wrist. The end effector can include an upper jaw, a lower jaw, and a firing mechanism configured to form staples in tissue. Actuation of the firing mechanism can be decoupled from the movement of the wrist in the at least two degrees of freedom.

A tissue oximetry device utilizes at least three or at least four different wavelengths of light for collection of reflectance data where the different wavelengths are longer than 730 nanometers. The three or four wavelengths are utilized to generate a range of reflectance data suited for accurate determination of oxygenated hemoglobin and deoxygenated hemoglobin concentrations. The relatively long wavelengths decrease optical interference from certain dyes, particularly methylene blue and PVPI, which may be present on tissue being analyzed for viability and further enhance the generation of accurate reflectance data. The wavelengths are 760 nanometers, 810 nanometers, and 850 nanometers, or 760 nanometers, 810 nanometers, 850 nanometers, and 900 nanometers.

A method for calibrating detectors of a self-contained, tissue oximetry device includes emitting light from a light source into a tissue phantom, detecting in a plurality of detectors the light emitted from the light source, subsequent to reflection from the tissue phantom, and generating a set of detector responses by the plurality of detectors based on detecting the light emitted from the light source. The method further includes determining a set of differences between the set of detector responses and a reflectance curve for the tissue phantom, and generating a set of calibration functions based on the set of differences. Each calibration function in the set of calibration functions is associated with a unique, light source-detector pair. The method further includes storing the set of calibration function in a memory of the self-contained, tissue oximetry device.

A surgical retractor for positioning within an incision within a body of a patient is described. The surgical retractor comprises a flexible air-impermeable bag surrounding an interior region and extending from a first end through a central region to a second end. The surgical retractor includes a first port in the central region, the flexible air-impermeable bag surrounding a first channel that extends from the first port towards the first end, a second port in the central region, the flexible air-impermeable bag surrounding a second channel that extends from the second port toward the second end, and a plurality of beads substantially filling the interior region of the flexible air-impermeable bag. The flexible air-impermeable bag is configured to rigidify in response to air being evacuated from the interior region to position and hold intra-incision contents within a surgical working space in a patient.

Disclosed are instruments and methods for acquiring co-registered orthogonal fluorescence and photoacoustic volumetric projections of an interrogated object. In an embodiment, an instrument includes a rotary mechanism configured to rotate an interrogated object relative to an array of photoacoustic transducers and an optical detector. An optical excitation unit is configured to irradiate the interrogated object with pulses of light, inducing both fluorescence and photoacoustic responses inside the interrogated object at each of a plurality of rotational positions. The array of photoacoustic transducers includes unfocused elements arranged in a pattern along an axis of rotation, the elements configured to detect photoacoustic signals generated inside the volume of the interrogated object. The optical detector is arranged opposite to the array of photoacoustic transducers with respect to the axis of rotation and is configured to register sources of fluorescence excited inside the interrogated object. Each of the optical excitation axes form with each of the optical detection axes, and with each of the photoacoustic detection axes, angles that are between 60° and 90° so as to enable acquisition of co-registered orthogonal fluorescence and photoacoustic volumetric projections of the interrogated object.

In certain embodiments, an ophthalmic procedure contact lens for ophthalmic treatment of an eye with a laser beam includes a frame, an objective lens, and an illumination ring. The frame has an eye end, an operator end, and a flange-like shape with an interior region. The eye end is configured to be disposed outwardly from the eye. The objective lens is disposed within the interior region of the frame. The objective lens transmits the laser beam through the eye end to treat the eye. The illumination ring is coupled to the frame and provides annular illumination through the eye end to illuminate the eye. The illumination ring includes a ring substrate and light emitters coupled to the ring substrate. The light emitters emit light.

A method for determining oxygen saturation includes emitting light from sources into tissue; detecting the light by detectors subsequent to reflection; and generating reflectance data based on detecting the light. The method includes determining a first subset of simulated reflectance curves from a set of simulated reflectance curves stored in a tissue oximetry device for a coarse grid; and fitting the reflectance data points to the first subset of simulated reflectance curves to determine a closest fitting one of the simulated reflectance curves. The method includes determining a second subset of simulated reflectance curves for a fine grid based on the closest fitting one of the simulated reflectance curves; determining a peak of absorption and reflection coefficients from the fine grid; and determining an absorption and a reflectance coefficient for the reflectance data points by performing a weighted average of the absorption coefficients and reflection coefficients from the peak.

A system to treat a patient comprises a user interface that allows a physician to view an image of tissue to be treated in order to develop a treatment plan to resect tissue with a predefined removal profile. The image may comprise a plurality of images, and the planned treatment is shown on the images. The treatment probe may comprise an anchor, and the image shown on the screen may have a reference image marker shown on the screen corresponding to the anchor. The planned tissue removal profile can be displayed and scaled to the image of the target tissue of an organ such as the prostate, and the physician can adjust the treatment profile based on the scaled images to provide a treatment profile in three dimensions. The images shown on the display may comprise segmented images of the patient with treatment plan overlaid on the images.