Device 1 for fixation to the skull 2 of a patient that can serve as a fiducial marker in scan guided surgical operations using a surgical instrument. The device 1 comprises a material translucent for the applied electromagnetic waves of the scan and a fiducial marker and where the device 1 comprises means to fixate the device in a well-defined manner to the surgical instrument.

Systems and methods for multi-modal sensing of three-dimensional position information of the surface of an object are disclosed. In particular, multiple visualization modalities are each used to collect distinctive positional information of a surface of an object. Each of the computed positional information is combined using weighting factors to compute a final, weighted three-dimensional position. In various embodiments, a first depth may be recorded using fiducial markers, a second depth may be recorded using a structured light pattern, and a third depth may be recorded using a light-field camera. Weighting factors may be applied to each of the recorded depths and a final, weighted depth may be computed.

A system and method for inductive heating applications includes positioning one or more inductive heating elements in a location, delivering electromagnetic radiation, by a radiation source, to heat at least a portion of the one or more inductive heating elements, and detecting, by a detector, the heat generated by the one or more inductive heating elements. The system and method also include controlling, by a processing unit, a condition based on the detected heat.

A fusogenic liposome comprising a detectable agent and optionally a cytotoxic drug in its internal aqueous compartment or bound to the liposome membrane is provided, wherein said fusogenic liposome comprises a lipid bilayer comprising a plurality of lipid molecules having 14 to 24 carbon atoms, and at least one of said lipid molecules further comprises a cationic group, a cationic natural or synthetic polymer, a cationic amino sugar, a cationic polyamino acid or an amphiphilic cancer-cell binding peptide; and at least one of said lipid molecules further comprises a stabilizing moiety selected from the group consisting of polyethylene glycol (PEG), polypropylene glycol, polyvinyl alcohol, polyvinylpyrrolidone (PVP), dextran, a polyamino acid, methyl-polyoxazoline, polyglycerol, poly(acryloyl morpholine), and polyacrylamide. Methods utilizing these liposomes in treatment of cancer are further provided.

A method comprises advancing a medical instrument and a catheter toward a target tissue within a patient anatomy. The instrument includes a distal sheath marker and is slidably received within the catheter. The distal sheath marker includes a channel and an identification feature. A portion of the instrument is slidably received within the channel. The method further comprises depositing the distal sheath marker at a location at or near the target. The distal sheath marker indicates a farthest advancement point of the instrument within the patient anatomy. The method further comprises: after depositing the distal sheath marker, withdrawing the instrument away from the target; determining an orientation of the distal sheath marker based on the identification feature; and, after withdrawing the instrument, using the location and orientation of the deposited distal sheath marker to determine a trajectory of a distal end of the instrument at or near the target.

A method of performing a transperineal biopsy procedure includes imaging the prostate with a transrectal ultrasound probe with a transperineal biopsy guide coupled to the probe. The transperineal biopsy guide including a mount coupled to the probe, a guide member coupled to the mount and including a rail receiving channel extending a first length, and a displacement member including a rail member extending a second length between a proximal end and a distal end, and a vertically extending member coupled to the distal end of the rail member. The vertically extending member including a plurality of needle receiving ports. The method further includes sliding the rail member within the rail receiving channel. The method further includes inserting an access needle into the perineal access site of the patient and inserting a needle through the access needle and into a first location of the prostate of the patient.

A system for aerating a marker material. The system includes a first container, a second container, and an aeration connector. The aeration connector includes a body and a screen disk disposed within the body. The first container is in communication with the second container via the aeration connector. The screen disk of the aeration connector is configured to aerate a marker material as the marker material is repeatedly passed between the first container and the second container.

This invention provides methods for marking a target location for a medical procedure, comprising topically, intradermally, subcutaneously, or intramuscularly administering to a subject in need of the medical procedure an ink composition in an amount that is effective to mark with an impermanent tattoo the target location of the medical procedure. The invention also provides methods for marking a subject, comprising topically, intradermally, subcutaneously, or intramuscularly administering to the subject a solid ink composition in an amount that is effective to mark the subject with an impermanent tattoo, wherein the ink composition comprises an ink particle, and wherein the ink particle has a (i) diameter ranging from about 10 nm to about 100 m or (ii) volume ranging from about 0.0001 mm.sup.3 to about 20 mm.sup.3.

The present disclosure 1s directed to systems and methods for endovascular electroencephalography (EEG) and electrocorticography (ECoG) systems. In some embodiments, the disclosed systems include electrode arrays that are configured to record and/or stimulate brain tissue via placement within blood vessels of the brain. Venous and arterial EEG and ECoG electrodes, ambulatory EEG and ECoG systems, and transcutaneous access and signal control systems for general and ambulatory endovascular electroencephalography (EEG) and electrocorticography (ECoG), as well as endovascular neural stimulating electrodes are discussed.

Methods of performing surgical operations and associated devices are disclosed. An example method may include locating a first position on a first surface of a biological tissue; locating a second position on a second opposing surface of the biological tissue, the second position corresponding to the first position; and marking the second position on the second surface. The second surface may be generally opposite the first surface. An example method may include, after marking the second position, performing a therapeutic procedure on the biological tissue in the vicinity of the second position.