Alignment systems and methods are disclosed. A system includes a first component and a second component. The first component has a first body supporting a first alignment member. The second component has a second body supporting a second alignment member. The first and second alignment members are separated from another and are configured to provide an indication that a fluoroscopic device is properly aligned with an anatomical plane when viewed under fluoroscopy. A method includes placing a first component supporting a first alignment member and a second component supporting a second alignment member relative to a patent, and aligning a fluoroscopic device with an anatomical plane using the first and second alignment members.

An ultrasound transducer assembly that includes a piezoelectric layer configured to resonate and generate ultrasound signals around a predetermined ultrasound frequency in which the piezoelectric layer has a width to thickness ratio of at least about 0.6. A conductive matching layer is connected to the top surface of the piezoelectric layer to condition the ultrasound transducer for broad frequency bandwidth operation. A conductive backing layer is connected to the bottom surface of the piezoelectric layer. The ultrasound transducer assembly further includes a rigid body over which the conductive backing layer is positioned, the rigid body assembled for encompassing a central longitudinal axis of a catheter body. A signal and ground electrode may form a metallic layer over the top of or below each of the piezoelectric layers. Electrical waveguides may be connected to corresponding signal and ground electrodes of the transducers.

A system for creating separation between biological surfaces may comprise a hollow body configured for delivery of a fluid to a target location, a fluid supply in fluid-communication with the hollow body, a control element configured to control the delivery of a fluid through the hollow body, at least one first sensor configured to measure at least one parameter of the fluid flowing through the hollow body, at least one second sensor configured to measure at least one parameter of an environment of the hollow body, a feedback control module configured to receive information from one or more of the at least one first sensor or the at least one of the second sensor to control at least one operational function of the system.

Described herein are systems and methods for performing optical signal analysis and lesion predictions in ablations. A system includes a catheter coupled to a plurality of optical fibers via a connector that interfaces with a computing device. The computing device includes a memory and a processor configured to receive optical measurement data of a portion of tissue from the catheter. The processor identifies one or more optical properties of the portion of tissue by analyzing the optical measurement data and determines a time of denaturation of the portion of tissue based on the one or more optical properties. A model is created to represent a correlation between lesion depths and ablation times using the time of denaturation, the one or more optical properties, and the predetermined period of time. A predicted lesion depth for a predetermined ablation time is generated using the model.

A catheter device having a distal tube portion having a longitudinal axis and a tube wall comprising at least one side port; and a guide tip mounted on the distal tube portion, the guide tip defining: a unitary body having an outer wall, and a plurality of indentations in the outer wall, wherein the indentations are oriented substantially parallel to the longitudinal axis, and wherein each indentation extends from a distal-most end of the guide tip to a proximal region of the guide tip.

Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the removal device. The removal device can have a core assembly that includes a hypotube coupled to a first electrical terminal and a pushwire coupled to a second electrical terminal, the pushwire extending through the hypotube lumen. An insulating layer separates the hypotube and the pushwire, and an interventional element is coupled to a distal end of the pushwire. The interventional element can be disposed adjacent to a thrombus. An electrical signal is delivered to the interventional element to promote adhesion of the thrombus to the interventional element. The electrical signal can optionally be a periodic waveform, and the total energy delivered can be between 0.75-24,000 mJ and the peak current delivered via the electrical signal can be between 0.5-5 mA.

A medical treatment device is disclosed herein. In one example, the medical treatment device includes a core assembly which has a first conduct and a second conductor, the second conductor being formed from a first conductive material. An insulative material can surround the second conductor and define one or more uninsulated portions. A second conductive material can surround the first conductive material along at least a portion of the one or more uninsulated portions and can have a higher electrical conductivity than the first conductive material. The medical treatment device can include an interventional element formed from a third conductive material that electrical couples to the first conductor. A fourth conductive material can be disposed over the third conductive material and have a higher electrical conductivity than the third conductive material.

Methods and devices for performing minimally invasive procedures useful for Fallopian tube diagnostics are disclosed. In at least one embodiment, the proximal os of the Fallopian tube is accessed via an intrauterine approach; an introducer catheter is advanced to cannulate and form a fluid tight seal with the proximal os of the Fallopian tube; a second catheter inside the introducer catheter is provided to track the length of the Fallopian tube and out into the abdominal cavity; a balloon at the end of the second catheter is inflated and the second catheter is retracted until the balloon seals the distal os of the Fallopian tube; irrigation is performed substantially over the length of the Fallopian tube; and the irrigation fluid is recovered for cytology or cell analysis.

Systems and methods are provided for injecting one or more agents into tissue within a patient's body. In one embodiment, an injection device includes a substantially axially incompressible elongate member including a lumen extending between proximal and distal ends thereof. A distal stop is provided on the distal end and a needle tip extends distally beyond the distal stop, the needle tip having a cross-section smaller than the distal end. The needle tip includes a passage communicating between the lumen and an outlet in the distal tip that has having a cross-section smaller than the lumen. In an exemplary embodiment, the elongate member includes a coil extending between the proximal and distal ends, and a sleeve disposed within an interior region of the coil extending between the proximal and distal ends. The sleeve defines the lumen and may be free-floating within at least a portion of the coil.

Provided is a laser surgical guidance system including a C-arm fluoroscopy (hereinafter, C-arm) to identify a patient's condition and support a surgical plan and a laser targeting projector to project a line of the surgical plan directly onto an affected part through a line projection module which generates a laser. The laser surgical guidance system may generate a particular laser pattern from the line projection module, transmit the particular laser pattern outputted from the line projection module through a calibration tool including a collimator having a particular orientation, calculate an extrinsic parameter of the calibration tool in a projection image having passed through the calibration tool, and convert coordinates of the C-arm image into the line projection module coordinates using the extrinsic parameter.