Various corneal marker tools and assemblies are provided for use in ophthalmic procedures to place ink marks on the cornea. One tool assembly includes an applicator containing an ink and a disposable marking tip attachable to the applicator, where ink is injected from the applicator into hollow channels of the marking tip. Another tool assembly includes a reusable handle and a disposable marking tip attachable to the handle. Another tool assembly includes a marker assembled with a cap with an ink pad. Another tool assembly includes a marker tool and a nesting adapter to be used with a patient interface device. Other tools have a one-piece design with a marker head and an handle fixedly joined together. Some tools have pre-inked marking elements, or an embedded light source, or a built-in level indicator, or a ring-shaped marker head, or a leaf spring feature on their marking prongs.

Markers, microwave probes, and related systems and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The marker includes an energy converter e.g., one or more photodiodes, for transforming energy pulses striking the marker into electrical energy, a switch, e.g., FET, coupled to the photodiodes such that light from a probe cause the switch to open and close. A pair of antenna wires are coupled to the switch to provide an antenna, the switch configured to open and close when light strikes the photodiodes to modulate signals from the probe reflected by the antenna back to the probe to identify the location of the marker. The marker also includes an electro static discharge (ESD) protection device coupled to the switch to provide protection against an electrostatic discharge event.

An impedance reflector apparatus, systems, and methods are provided for detecting a marker implanted within tissue that includes a switch for changing a configuration of an antenna of the marker. The apparatus includes a set of transmit electrodes coupled to a signal generator for transmitting a drive current into tissue to generate an electromagnetic field around the marker, a set of receive electrodes configured to detect voltage signals within the tissue corresponding to the electromagnetic field, and a light source for delivering light pulses into the body to open and close the switch to change the configuration of the antenna of the marker. A processor coupled to the receive electrodes processes the detected voltage signals to identify changes in the electromagnetic field that are synchronized with the light pulses to determine whether the marker is operating properly.

Embodiments of the invention provide a system and method for resecting a tissue mass. The system for resecting a tissue mass includes a surgical instrument and a first sensor for measuring a signal corresponding to the position and orientation of the tissue mass. The first sensor is dimensioned to fit insider or next to the tissue mass. The system also includes a second sensor attached to the surgical instrument configured to measure the position and orientation of the surgical instrument. The second sensor is configured to receive the signal from the first sensor. A controller is in communication with the first sensor and/or the second sensor, and the controller executes a stored program to calculate a distance between the first sensor and the second sensor. Accordingly, visual, auditory, haptic or other feedback is provided to the clinician to guide the surgical instrument to the surgical margin.

An implant injection device, including an injection needle, a receiver housing for receiving at least one implant, an injection mechanism, the injection mechanism including a pushing rod, arranged upstream from the at least one implant housed in the receiver housing, extending longitudinally and configured to push the at least one implant through the injection needle between an initial position and a final position in which the at least one implant is injected, a mechanism for actuation by a user, configured to actuate a displacement of the pushing rod from the initial position to the final position, the mechanism for actuation including a rack transmission mechanism.

Removable marker implants having fiducial markers disposed on multiple elongate members extend and splay laterally outward when deployed thereby providing improved 3D localization and tracking of a portion of the patient's body for stereotactic radiosurgery. Such an approach is particularly useful for tracking of the uterus during radiosurgery treatment of uterine fibroids. Such implants can include an outer sheath that contains the multiple elongate members during delivery into the portion of the body. The elongate members can be slidably disposed within the shaft and advanced into an expanded deployed position by advancement of an applicator shaft or rod within the sheath. Marker implant can also be integrally formed implants with flexible arms having fiducial markers thereon that can be constrained in a sheath for delivery and resiliently splay laterally outward when released from the shaft. Methods of delivery and deployment are also provided.

A radiopaque anchor and delivery device system may comprise a pigtail catheter and a radiopaque anchor. The pigtail catheter may be a dual lumen catheter configured to deploy the radiopaque anchor and delivery a radiopaque fluid or contrast agent. The implantable radiopaque anchor may be slidably disposed within and deployable from a lumen of the elongate shaft.

A biopsy marker device includes: a biopsy marker; and an encapsulation member surrounding the biopsy marker. The encapsulation member comprising a compressible material that is configured to move between a compressed position around the biopsy marker and an expanded position post-deployment.

Medical devices useful in interventional procedures performed under magnetic resonance imaging (MRI) are described herein. A medical device comprises a body member and a marker formed of work-hardened stainless steel attached to the body member. The stainless steel of the marker has an ultimate tensile strength of between about 100 KSI and about 225 KSI. The marker can be attached to the body member in a manner that contributes work to the stainless steel or in a manner that does not contribute work to the stainless steel. Methods of making medical devices, medical imaging methods, and methods of performing interventional medical treatment are also described herein.

A localization tool for localizing and marking a nodule of a patient includes a magnetic portion for locating a magnetic fiducial marker disposed in or adjacent the nodule, and an electrocautery element for marking the nodule or tissue adjacent the nodule upon locating the magnetic fiducial marker.