System and methods are disclosed to facilitate intra-operative procedures and planning. A method can include storing tracking data in memory, the tracking data being generated by a tracking system to represent a location of an object in a tracking coordinate system of the tracking system. The method can also include storing a patient-specific implicit model in memory, the patient-specific implicit model being generated based on image data acquired for the patient to define geometry of an anatomical structure of the patient. The method can also include registering the tracking data and the patient-specific implicit model in a common three-dimensional coordinate system. The method can also include generating an output visualization representing a location of the object relative to the geometry of the anatomical structure of the patient in the common coordinate system.

An example method includes acquiring a first image using a medical imaging modality that includes a two-dimensional field of view to include a patient and a multi-modal marker. A second image is acquired using the medical image modality. The second image includes the patient and the multimodal marker and is along a non-coincident angle with respect to the first image. Predetermined portions of the multi-modal marker are visible in the first and second images and have a known location and orientation with respect to at least one sensor detectable by a tracking system. The method also includes estimating a three-dimensional position for predetermined portions of the multi-modal marker. The method also includes determining an affine transformation for registering a three-dimensional coordinate system of the tracking system with a three-dimensional coordinate system of the medical imaging modality.

Systems and methods for tracking a target volume, e.g., tumor, in real-time during radiation treatment are provided. The system includes a memory to store a pre-acquired 3D image of the anatomy of interest in a first reference frame and a processor, operative coupled with the memory, to receive, from an ultrasound probe, a set-up ultrasound image of the anatomy of interest in a second reference frame. The processor further to establish a transformation between the first and second reference frames by registering the set-up ultrasound image with the pre-acquired 3D image and receive, from the ultrasound probe, an intrafraction ultrasound image of the anatomy of interest. The processor further to register the intrafraction ultrasound image with the set-up ultrasound image and track motion of the anatomy of interest based on the registered intrafraction ultrasound image.

3D image data of a skeletal portion is acquired. A location of a proximal portion of a tool is calculated and a location is derived of a distal portion of the tool with respect to the skeletal portion, with respect to the 3D image data. A display indicates the derived location. First and second 2D images of the distal portion of the tool are acquired from two different poses of a 2D imaging device with respect to the subject and registered with the 3D image data. The location of the distal portion with respect to the 3D image data of the skeletal portion is determined based on the registration and an identified location of the distal portion within the 2D x-rays. Based upon the determined location, the display updates the indicated location of the distal portion. Other embodiments are also described.

A method of making an intracorporeal marker, including the method steps of providing a core having a first material with porous hydroxyapatite; and completely covering the core an outer region having a second material with less porous hydroxyapatite, wherein ultrasonic or radiative imaging reveals a difference between the marker and tissue.

The present invention is directed to a system and method for image to world registration for medical reality applications, using a world spatial map. This invention is a system and method to link any point in a fluoroscopic image to its corresponding position in the visual world using spatial mapping with a head mounted display (HMD) (world tracking). On a projectional fluoroscopic 2D image, any point on the image can be thought of as representing a line that is perpendicular to the plane of the image that intersects that point. The point itself could lie at any position in space along this line, located between the X-Ray source and the detector. With the aid of the HMD, a virtual line is displayed in the visual field of the user.

The present invention relates to a medical tracking system comprising at least one sensor device which can be positioned in a fixed position relative to a target, the sensor device comprising a marker device and a marker device detector, the marker device detector being capable of obtaining information for determining a relative position between the marker device detector and another marker device, the system further comprising a control unit configured to process a medical navigation workflow and to select the function of the sensor device as either acting as a marker device detector or as a marker device in a step of the medical navigation workflow.

Multi-modal imaging capsule for image-guided proton beam therapy, consisting of a biocompatible polymer layer, .sup.18O-enriched water, and a contrast agent. The biocompatible capsule may be inserted near or inside a tumor under the guidance of X-ray, magnetic resonance, or ultrasonography imaging. Upon proton beam irradiation, the capsule emits positrons, allowing the tumor to be imaged and tracked by a PET detector.

A system and a method are disclosed that allow for generation of a model or reconstruction of a model of a subject based upon acquired image data. The image data can be acquired in a substantially mobile system that can be moved relative to a subject to allow for image acquisition from a plurality of orientations relative to the subject. The plurality of orientations can include a first and final orientation and a predetermined path along which an image data collector or detector can move to acquire an appropriate image data set to allow for the model of construction.

The invention relates to a navigation system for dental and cranio-maxillofacial surgery, comprising a surgical handpiece (2), an imaging unit (4) which is movably attached to the surgical handpiece (2), and a marker member (6; 44, 46) which is attachable to a cranial bone, a facial bone (26), a tooth or teeth of a patient. The marker member (6; 44, 46) comprises a plurality of marker elements (8, 10; 46) which are detectable by the imaging unit (4). Further, the invention relates to a positioning tool (40) for use with the navigation system, wherein the positioning tool (40) is configured for positioning the marker member (44, 46) on a patient's cranial bone, facial bone (26), tooth or teeth and comprises a die element (42) and the marker member (44, 46). The marker member (44, 46) comprises a deformable material (44), the deformable material (44) is releasably received in the die element (42) and the plurality of marker elements (46) are arranged on a surface of the deformable material (44) which faces the die element (42), The invention further relates to a navigation method for dental and craniomaxillofacial surgery using the navigation system and to a method of positioning a marker member (44, 46) on a patient's cranial bone, facial bone (26), tooth or teeth using the positioning tool (40).