Systems and methods for image-guided medical procedures use fluoroscopic 3D reconstructions to plan and navigate a percutaneously-inserted device such as a biopsy tool from an entry point to a target.

A medical procedure system, including a medical instrument to be inserted into a body part, and including position-tracking transducers to provide position signals, a distal end, and at least one radiopaque marker, a position tracking sub-system to compute a position including at least one location and orientation of the distal end in a position-tracking sub-system coordinate frame responsively to the position signals, a fluoroscope to capture fluoroscopic images of an interior of the body part and the radiopaque marker(s), and a registration sub-system to render, to a display, the captured fluoroscopic images including at least one marker-image of the radiopaque marker(s), and at least one graphical representation indicative of the computed position of the distal end, receive user-alignment input aligning the graphical representation(s) with the marker-image(s), and register the position-tracking sub-system coordinate frame with a coordinate frame of the fluoroscope responsively to the received user-alignment input.

The present disclosure relates to systems and methods to perform a surgical procedure. The systems and methods utilize MRI-compatible fiducial markers including a body having at least one feature configured to receive an MRI-compatible and MRI-visible material and to allow registration of a navigational tool. The MRI-compatible fiducial markers can be affixed to a bone of a patient. The registered navigational tool can be used to advance a surgical tool along a navigational path to perform a surgical procedure.

In general, devices, systems, and methods for fiducial identification and tracking are provided.

Markers for use in bodily tissue take a variety of forms, and may include a plurality of ultrasound reflective elements, for example hollow shells filled with air, and a hydrogel that binds the ultrasound reflective elements. The hydrogel may be natural or artificial and may be cross-linked. An ultrasound system advantageously injects variance in a drive signal, that varies a frequency or phase of an ultrasound interrogation signal from a nominal frequency or nominal phase. The amount of variation is preferable one to six orders of magnitude less than the nominal frequency or phase. The ultrasound system can present or detect a twinkling artifact at least in a Doppler mode of operation, resulting from interaction of the varying interrogation signal with the ultrasound reflective elements.

The present invention is directed to an implantable medical device, comprising: a device body, with at least a portion of said body coated by a sensing coating that comprises an echogenic material or a radiopaque material, or combinations thereof, said sensing coating configured to dissolve or swell in presence of at least one infection biomarker; wherein a portion of said sensing coating is covered by a protective film, forming a protected portion, said protected portion configured not to dissolve or swell in presence of said biomarker and methods of detecting presence of biomarkers in the vicinity of an implanted medical device.

A method for postural independent location of targets in diagnostic images acquired by multimodal acquisitions, compensating for deformation of soft tissues due to changing posture, includes generating a transition of a digital image of the inside of a target region from a first to a second position by correlating the position of markers placed on the external surface of the target region in a digital image of the inside of the target region and in a digital representation of the external surface of the target region acquired by optically scanning the external surface; and at a later time registering the diagnostic image of the inside of the target region, transitioned into the second position, with a diagnostic image of the same target region acquired with the target region in the second position by matching a second representation of the external surface of the target region in the second position without markers with the diagnostic image of the inside of the target region transitioned into the second position.

A surgical system including a patient tracker and a tracking system. The patient tracker is adapted for attachment to a patient, and includes a hybrid marker having a radiological marker contained within an optical marker. The tracking system tracks the hybrid marker. A computing device obtains a three-dimensional image of a patient' s anatomy and the attached patient tracker; identifies a three-dimensional portion of the hybrid marker within a scan volume; determines a location of the hybrid marker within the scan volume based on the identified three-dimensional portion; tracks the location of the hybrid marker in three-dimensional space using the tracking system while the patient tracker remains fixed to the patient; and registers the three-dimensional image in three-dimensional space based on a known geometric relationship between the location of the hybrid marker within the scan volume and the location of the hybrid marker in three-dimensional space.

The application describes embodiments including, e.g., a measurement device comprising: a casing, a first magnet arranged within the casing such that it is rotatable out of an equilibrium orientation responsive to an external magnetic torque acting on the first magnet, a second magnet to provide a restoring torque to force the first magnet back into the equilibrium orientation responsive to an external magnetic torque rotating the first magnet out of the equilibrium orientation, allowing for a rotational oscillation of the first magnet, which is excited by the external magnetic torque, with a resonant frequency, and a temperature sensitive magnetic material to modify the resonant frequency.

Multi-modal imaging capsule for image-guided proton beam therapy, consisting of a biocompatible polymer layer, .sup.18O-enriched water, and a contrast agent. The biocompatible capsule may be inserted near or inside a tumor under the guidance of X-ray, magnetic resonance, or ultrasonography imaging. Upon proton beam irradiation, the capsule emits positrons, allowing the tumor to be imaged and tracked by a PET detector.