The present invention provides a method of penis enlargement. The method comprises administering to a site of penis of a subject a graft enriched with adipose derived regenerative cells.

Disclosed are a cell-free fat extract and a preparation method therefor and the method of use thereof. The cell-free fat extract is used for preparing a composition or a preparation, wherein the composition or preparation is used in a method of: preventing and/or treating acute respiratory distress syndrome and/or acute lung injury, preventing and/or treating hypoxemia, improving pulmonary tissue inflammations, improving pulmonary tissue injuries, preventing and/or treating systemic inflammatory response syndrome, and preventing and/or treating multiple organ failure.

Obesity and related conditions and diseases pose ever increasing issues for the developed world. There is a need for interventions that can treat/prevent the underlying causes of e.g., diabetes and obesity. Accordingly compositions and methods for altering at least one expression level related to cellular metabolism are disclosed herein.

Disclosed is a chimeric polypeptide for use in-vitro tissue engineering, the polypeptide including cellulose binding domain (CBD), a cell effector protein (CEP), and a linker linking the CBD to the CEP, as well as systems and method utilizing same.

A method for elongating telomeres of cells comprises steps of: providing physical stimulation directly or indirectly to cells; and culturing a mixture of the cells and a medium for a predetermined time, wherein providing the stimulation directly to the cells comprises applying physical stimulation to the medium containing the cells, and providing the stimulation indirectly to the cells comprises applying physical stimulation to the medium not containing the cells and then mixing the medium and the cells. The method for elongating telomeres of cells is simpler than a conventional method and is superior in terms of time, cost, efficiency, and safety. In addition, the method induces cell division and provides an anti-aging effect, in addition to simply elongating telomeres. Thereby, it is expected that the method can ameliorate and prevent not only problems caused by shortening of telomeres, but also various aging-related diseases and conditions.

Systems and methods for producing food products including cultured food products. The cultured food products include sushi-grade fish meat, fish surimi, foie gras, and other food types. Various cell types are utilized to produce the food products and can include muscle, fat, and/or liver cells. The cultured food products are grown in pathogen-free culture conditions without exposure to toxins and other undesirable chemicals. The food products can be processed to provide a desired shape, texture and consistency.

A device and method for the extraction of stem cells from adipose tissue wherein an adipose tissue dissolved in an isotonic solution is subjected to a washing operation and subsequent filtering step and to centrifugation operations to initiate three stem cell cultures thereby maximising in this manner the yield of the sample collected.

In certain aspects, the present invention provides compositions and methods for increasing thermogenic adipocytes (e.g., brown adipocytes or other UCP-1 expressing adipocytes) by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-myostatin antibodies, anti-GDF3 antibodies, anti-Nodal, anti-activin, and anti-GDF11 antibodies. A variety of metabolic and other disorders may be treated by causing an increase in thermogenic adipocytes.

An object of the present invention is to provide a method for preparing osteoblasts that are applicable, without causing risk of canceration, to bone defect repair or to the treatment of bone resorption, fracture, osteoporosis, or the like. To solve this problem, the present invention provides a method for preparing osteoblasts, the method comprising culturing mammal differentiated somatic cells in a medium in the presence of at least one compound selected from the group consisting of (1) statin compounds, (2) casein kinase 1 inhibitors, (3) cAMP inducers, and (4) histone methyltransferase inhibitors, to convert the somatic cells into osteoblasts.

The present disclosure provides methods and compositions useful for the production of slaughter-free meat products, and the characterizations of the same. The slaughter-free meat products contain several points of distinction when compared to conventional meat procured by harvesting the tissue of a dead animal. Such points of distinction include, but are not limited to, significantly reduced or substantially no: steroid hormones, antibiotics, or microbial contamination; lower fat content; no vasculature; and extended shelf life both at room temperature and when refrigerated.