A medical device includes a hybrid circuitry assembly and a core circuitry support structure. The core circuitry support structure includes a frame defining a cavity configured to receive at least a portion of the hybrid circuitry assembly. An outer surface of the frame is shaped to correspond to an inside surface of a core assembly housing configured to enclose the hybrid circuitry assembly and the core circuitry support structure.

A system and device for cryoablation of tissue that is suitable for use within an MRI environment. The device may include an elongate body, a treatment element at the distal portion of the elongate body, and one or more pull fibers. The pull fibers may be composed of a non-ferromagnetic material, such as a polymer. Likewise, none of the other device components may be composed of a ferromagnetic material. The device may also include at least one fiber optic sensor. The elongate body distal portion may include a distal tip to which the pull fibers are directly coupled. Additionally or alternatively, the elongate body may include one or more pull fiber lumens configured to allow the pull fibers to deflect the distal portion when a pull force is exerted on the pull fibers.

Techniques for acquiring and processing data in combination with a photonic sensor system-on-a-chip (SoC) (1) to provide real-time calibrated concentration levels of an analyte (e.g., a constituent molecule within a biological substance) are described. A raw signal (1300) to be analyzed is collected by the sensor chip (1) via diffuse reflectance or transmittance. Determination of the analyte concentration is based on, in part, Beer-Lambert principles and facilitated by applying (2240) scattering correction to the raw signal (1300) prior to decomposition and analysis thereof.

A medical system for minimally-invasive measurement of blood flow in an artery (AT). An interventional device (IVD) with an optical fiber (FB) comprising a plurality of temperature-sensitive optical sensor segments, e.g. Fiber Bragg Gratings, spatially distributed along its longitudinal extension is configured for insertion into an artery (AT). A temperature changer (TC) is arranged in the WD to introduce a local change in temperature (ΔT) of a bolus of blood in the artery, to allow thermal tracking over time with the optical fiber (FB). A measurement unit (MU) with a laser light source (LS) delivers light to the optical fiber (FB) and receives light reflected from the optical fiber (FB) and generates a corresponding time varying output signal. A first algorithm (A1) translates this time varying output signal into a set of temperatures corresponding to temperatures at respective positions along the optical fiber (FB). A second algorithm (A2) calculates a measure of blood flow (BF) at respective positions along the optical fiber (FB) in accordance with a temporal behavior of said set of temperatures. Such system can be used to quickly scan an artery for diagnosing stenotic regions without the need for pullbacks or injection of toxic liquids. A good spatial resolution of the blood flow measurement can be obtained in real-time.

A venous positioning projector includes an infrared light source module, a light splitting element, an infrared light image capture module, a processor, and a visible light projection module. The infrared light source module outputs a first infrared light to a target surface. The infrared light image capture module includes a filter and an infrared light image capture element. The light splitting element transmits a second infrared light reflected by the target surface to the filter. The infrared light image capture element receives the second infrared light passing through the filter. The processor generates venous image data according to the first infrared light and the second infrared light received by the infrared light image capture element. The visible light projection module generates a visible light based on the venous image data. The visible light is transmitted to the target surface through the light splitting element to generate a venous image.

An optical sensor system and method of manufacture thereof can include: providing a sensor body; mounting a light emitter to the sensor body, the light emitter for emitting light into tissue; mounting a light detector to the sensor body for providing a physiological measurement from within the tissue; and affixing an optical film above the light detector, the light being angularly constrained by the optical film.

A scanner for scanning a dental site comprises a base, a detector mounted to the base, and an optical element to redirect light reflected off of the dental site towards the detector along a detection axis in a first direction. Two or more flexures couple the optical element to the base, wherein the two or more flexures maintain an alignment of the optical element to the detector with changes in temperature.

A temperature detection system (10) comprising a layer of spin cross-over material (11) in thermal contact with a target surface (12); at least one first light source (13) configured to provide a first and a second illumination (13a, 33a) of at least a first portion (12a) of the layer of spin cross-over material (11); at least one first light receiver (14) configured to capture first and second return light (14b, 34b) coming from the layer of spin cross-over material (11) and resulting respectively from the first and second illuminations; generate a first signal (S1) based on the first return light (14b); and generate a second signal (S2) based on the second return light (34b); a computation circuit (15, 17) configured to determine, based at least on a correlation between the first and second signals (S1, S2), a temperature of the layer of spin cross-over material (11).

An optical transmitter includes a light source and an adjustment structure. The light source is configured to output an original light spot, to transmit a test optical signal to a skin of a user. The adjustment structure is located on an output optical path of the test optical signal. A test optical signal transmitted from an original light spot center of the original light spot is a central light spot optical signal, and the adjustment structure is configured to scatter the central light spot optical signal in a direction away from the original light spot center, to convert the original light spot

The present disclosure relates to methods of collecting and testing bacteria containing samples from within the gastrointestinal (GI) tract of a subject. The methods may include disposing an ingestible device in the GI tract, collecting a bacteria-containing sample from the GI tract, selectively lysing eukaryotic cells in the sample by combining the sample with a dried reagent, exposing bacteria in the sample to resazurin in the ingestible device to produce resorufin, emitting light from the ingestible device, the emitted light being filtered through an optical filter to control for scatter so that the light interacts with the resorufin to produce fluorescence, and measuring a total fluorescence from the resorufin; or a rate of change of fluorescence from the resorufin as a function of time within the GI tract of the subject; and correlating the measured parameter to a number of viable bacterial cells in the sample.