The subject of this disclosure is devices, systems, and uses thereof to treat a plurality of patients for paroxysmal atrial fibrillation. The solution can include delivering a multi-electrode radiofrequency balloon catheter and a multi-electrode diagnostic catheter to one or more targeted pulmonary veins; ablating tissue of the one or more targeted pulmonary veins using the multi-electrode radiofrequency balloon catheter; diagnosing the one or more targeted pulmonary veins using the multi-electrode diagnostic catheter; and achieving at least one of a predetermined clinical effectiveness and acute effectiveness of the method or use based on use of the multi-electrode radiofrequency balloon catheter and the multi-electrode diagnostic catheter in the isolation of the one or more targeted pulmonary veins.

A system for mapping neuromuscular junctions for botulinum neurotoxin (BoNT) injections includes a stimulation electrode and an electromyography (EMG) sensor array including EMG sensors configured to be arranged about a person's face. Each EMG sensor detects muscle activity of a facial muscle of a facial muscle group. An EMG amplifier includes a plurality of input channels. Each input channel receives data of facial muscle activity in the facial muscle group from the EMG sensor array. A computer is in communication with the EMG amplifier. A processor of the computer identifies neuromuscular junctions (NMJs) of the facial muscle group based on the data of facial muscle activity received from the EMG sensor array. The plurality of NMJs are mapped with respect to the at least one facial muscle group of the body of the person. At least one NMJ site for BoNT injection is recommended by the computer.

Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for supporting components of an implantable medical device. The apparatuses, systems, and methods may include a first electrode and a second electrode and a scaffold assembly configured to support the first electrode and the second electrode.

A system for diagnosing and quantifying an organ prolapse includes a first manometry catheter configured for insertion within a first organ of the pelvic floor. The first manometry catheter includes an inflatable balloon configured to support a series of first sensors disposed along a length thereof and operably coupled to an image display for displaying a first image thereon relating to the first organ. One or more additional manometry catheters are configured for insertion within one or more respective additional organs. The additional manometry catheters include inflatable balloons configured to support corresponding additional sensors along a length thereof. The additional sensors are operably coupled to the image display for displaying one or more additional images thereon relating to the one or more additional organs. The first image and the one or more additional images being simultaneously displayed on the image display for diagnostic and quantification purposes.

The object of the present invention is the method to assess the pelvic floor muscle injury, comprising the steps of applying the measuring probe into the anus, generation of electric current signals of constant amplitude, using a current generator, and applying the signals into the pelvic floor muscles by means of application electrodes (EA1) and (EA2), detection of electric voltage signals from the pelvic floor muscles by means of a plurality of measuring electrodes (EP1), EP2 . . . EPn, analysis of electric current and voltage signals for amplitude values and phase dependencies of their waveform, wherein the electric current signals and the electric voltage signals from the pelvic bottom muscles constitute signals variable in time, of the frequencies ranging from 2 kHz to 200 kHz. The object of the invention is also an electrode based measuring probe and apparatus implementing the method of assessment pelvic floor muscles injury.

An apparatus with a first photodetector and a second photodetector is provided. The apparatus is configured to receive light, and the first photodetector is configured to detect a first portion of the light. The first photodetector and the second photodetector are in a stacked arrangement and the apparatus is configured to pass a second portion of the light through the first photodetector to the second photodetector. The apparatus further includes an optical blocking filter configured to filter the second portion of the light prior to the second portion of the light arriving at the second photodetector.

Pressure sensing guidewire assemblies are described herein where the guidewire assembly may be comprised of an elongate guidewire body and multiple pressure sensors secured near or at a distal end of the guidewire body. The signals obtained from the guidewire connectors and aortic sensor modules may be synchronized to minimize signal acquisition delays. The signals may be further processed to equalize the pressure waveforms by shifting the connector waveform to align correctly with the aortic module waveform and improve output signals.

A method of monitoring cardiac dysfunction, such as pericardial effusion, is disclosed. The method uses an indwelling probe inserted within a coronary sinus or a chamber or vessel of the heart, the probe having motion sensing means configured to sense motion of the probe based on movement of the wall of the coronary sinus or other chamber or vessel. Data is obtained from the motion sensing means and processed to monitor for cardiac dysfunction. The monitoring can be in real-time and can utilise one or more three-axis accelerometers. In some embodiments, two or more three-axis accelerometers are spaced longitudinally along an elongate body of the probe, which can increase accuracy and reliability of monitoring.

A sensor (110), a sensor assembly (256) for detecting at least one analyte in a body fluid and methods of manufacturing a sensor (110) and a sensor assembly (256) for detecting at least one analyte in a body fluid are disclosed. The sensor (110) has at least one substrate (114). The sensor (110) further has at least two electrodes (116) applied to the substrate (114), wherein the electrodes (116) are adapted for detecting the analyte. The sensor (110) further has at least two contact pads (118) applied to the substrate (114) and at least two electrical traces (120) applied to the substrate (114). The electrical traces (120) electrically connect the electrodes (116) and the contact pads (118). The sensor (110) further comprises a sealing ring (134) fixedly applied to the substrate (114). The sealing ring (134) surrounds the contact pads (118).

In some examples, a medical device system includes an electrode. The medical device system may include impedance measurement circuitry coupled to the electrode, the impedance measurement circuitry may be configured to generate an impedance signal indicating impedance proximate to the electrode. The medical device system may include processing circuitry that may be configured to identify a first component of the impedance signal. The first component of the impedance signal may be correlated to a cardiac event. The processing circuitry may be configured to determine that the cardiac event occurred based on the identification of the first component of the impedance signal.