An apparatus with a first photodetector and a second photodetector is provided. The apparatus is configured to receive light, and there is an optical arrangement configured to split the light received at the apparatus so that a first portion of the light is directed to the first photodetector and a second portion of the light is directed to the second photodetector. An optical blocking filter is configured to filter the second portion of the light prior to the second portion of the light arriving at the second photodetector.

The present invention relates to a device for detecting individual tumor cells, tumor clusters and micro metastases in the circulatory system which are enriched with a photo-sensitive substance. It is the object of the invention to provide a device allowing both a secure diagnostic detection of individual tumor cells in the circulatory system of humans and mammals and their therapeutic elimination in situ. This task is solved by a device comprising a radiation source (7, 11) with intravascular or extravascular excitation of the photo-sensitive substance, a detector (1, 12, 13) with intravascular or extravascular detection of a fluorescence and/or phosphorescence and/or luminescence radiation of the excited tumor cells and/or tumor clusters and/or micro metastases, a high sensitivity fluorescence spectrometer (5), connected to said detector (1, 12, 13), for detecting the emitted radiation, a computer (6) connected to said spectrometer (5) recording the received peaks of the emitted radiation as a function of time.

Aspects relate to an energy harvesting device adapted for use by an athlete while exercising. The device may utilize a mass of phase-change material to store heat energy, the stored heat energy subsequently converted into electrical energy by one or more thermoelectric generator modules. The energy harvesting device may be integrated into an item of clothing, and such that the mass of phase change material may store heat energy as the item of clothing is laundered.

Provided herein are quantitative optoacoustic tomography systems and methods for dynamic of functional parameters in a subject, for example, to assess conditions of the peripheral vasculature. The system generally has a pulsed laser, a fiberoptic optic bundle light delivery system, and imaging module, an array of ultrawide-band ultrasonic transducers, a circulation system, and electronics/computer system for system control and three-dimensional and two-dimensional optoacoustic image visualization. Also provided is a method for quantitative optoacoustic tomography of an appendage where an appendage of a subject is imaged under conditions of normal, maximum and minimum tolerable temperatures and displaying differential anatomical images of peripheral vasculature in the appendage and functional diagnostic parameters as a function of time and temperature. From this data medical conditions of the appendage may be diagnosed.

A finger insert for use with a nailfold imaging device includes a housing to receive the user's finger and an immersion substance (e.g., immersion oil), and a deformable pad that holds the user's finger in place during imaging, as well as prevent bubble formation in the substance. The housing includes a transparent wall to facilitate imaging of the finger. The transparent wall includes multiple angled portions that prevent or reduce contact between the nailfold and the wall, to ensure sufficient blood flow through the nailfold region for imaging.

The present disclosure describes a wearable computing device (WCD) in the form of a ring that can be worn on the finger of a human user.

The present invention provides a removable optical imaging device cap for use with a near infrared (NIR) light optical imaging device for detecting intracranial hematoma.

Method and apparatus can be provided according to an exemplary embodiment of the present disclosure. For example, with at least one first section of an optical enclosure, it is possible to provide at least one first electro-magnetic radiation. In addition, with at least one second section provided within the enclosure, it is possible to cause, upon impact by the first radiation, a redirection of the first radiation to become at least one second radiation. Further, with at least one third section of the optical enclosure, it is possible to cause at least one second radiation to be provided to a tissue. For example, the redirection of the first radiation causes, at least approximately, a uniform optical illumination on of a surface of the tissue.

Optical sensors, systems, and methods are described, which may be used to provide or analyze information about a subject. The optical sensor may be placed in proximity to the subject and may include optical sources and optical detectors. The optical sources may irradiate the subject with optical signals and the optical detectors can detect signals from the subject. Analysis of the detected signals can yield information about the subject.

An apparatus for extracorporeal treatment of blood (1) comprising a treatment unit (2), a blood withdrawal line (6), a blood return line (7), a preparation line (19) and a spent dialysate line (13); a non-invasive blood volume sensor (50) for determining an additional property of blood is active on a tube segment (61) of the blood withdrawal line or of the blood return line; the sensor includes one source (53) for directing a signal towards the blood, a plurality of detectors (57) for receiving the signal, and a controller (65) receiving the output signals from the detectors (57) and determining a blood volume variation and a value of sodium concentration in the blood (Na.sub.pl) both based on the output signals. A process of determining at least one parameter and on property of blood circulating an extracorporeal blood circuit is also disclosed.