A gastrointestinal treatment system including a gastrointestinal capsule adapted to treat a subject following ingestion of the gastrointestinal capsule. The gastrointestinal capsule includes: (a) a housing; (b) a vibrating agitator, powered by the battery, the vibrating agitator adapted such that, in a first vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule; (c) a power supply disposed within the housing and adapted to power the vibrating agitator; and (d) a controller adapted, in response to receipt of an activation input, to activate the vibrating agitator to operate in the first vibrating mode of operation at at least one predetermined time of day. The system and method may be used to treat an ailment of the gastrointestinal tract and/or to mitigate at least one symptom of jetlag in a subject travelling from an origin location to a destination location.

The capsule includes a tubular body and a front-end unit including an anchoring member for the anchoring of the capsule to a wall of a patient's organ. The front-end unit is mobile in relative axial rotation with respect to the tubular body, and a disengageable coupling member is adapted to allow this relative rotation when the tubular body receives an external rotational stress, the anchoring member then exerting a reaction torque higher than a predetermined threshold torque, and to prevent the relative rotation in the absence of external rotational stress applied to the tubular body. The coupling member may in particular include, between the front-end unit and the tubular body, a friction interface, with an elastically deformable element applying an axial compression between a bearing face of the tubular body and a support ring integral with the anchoring member.

Disclosed is a radio antenna comprising a substrate of dielectric material; a ground plane of electrically conductive material on a first face of the substrate; a resonator for converting an incident electrical signal into an electromagnetic wave and for resonating at at least two different resonant frequencies. The resonator comprises at least three elements, each in the form of strips of conductive material and arranged on a second face of the substrate opposite the first face. A second element is electrically connected to the ground plane by means of a via passing through the substrate at a first end of the corresponding strip, forms an extension of the first element, and is electrically connected directly to the first element at a second end of said strip which is opposite the first end.

A noise-separating cardiac monitor is provided. An implantable housing includes an external surface. A wireless antenna is shaped to wrap around an interior periphery of the implantable housing. Electrodes are provided on a ventral surface of the implantable housing to capture P-wave signals and R-wave signals. Electronic circuitry is provided within the wearable housing and includes a low power microcontroller. A front end circuit includes a signal lead operable to sense cardiac electrical potentials through one of the electrodes, a reference lead operable to sense the cardiac electrical potentials through another electrode, and a reference generator configured to inject a driven reference to the reference lead. The signal lead includes a coupling capacitor and a protection resistor associated with thermal noise. The thermal noise is not contained in the driven reference and not introduced to the reference lead. A non-volatile memory is electrically interfaced with the microcontroller.

A medical device includes a hybrid circuitry assembly and a core circuitry support structure. The core circuitry support structure includes a frame defining a cavity configured to receive at least a portion of the hybrid circuitry assembly. An outer surface of the frame is shaped to correspond to an inside surface of a core assembly housing configured to enclose the hybrid circuitry assembly and the core circuitry support structure.

Systems and methods described herein use near field communications to locate a radiating transponder, such as a pill swallowed by a patient. The system can be triggered to turn on and transmit a waveform to a set of antennas attached to, coupled with, or near the patient. The magnetic field emitted by the transponder can be measured by the receiving antennas, for example, using principles of mutual inductance. The differential phase and/or time shifts between the antennas can contain sufficient information to find the location of the transponder and optionally its orientation relative to body coordinates. The system can display the location and/or orientation of the transponder. Further, the pill can include a reservoir to deliver a payload at a particular site of the patient's body based at least in part on the determined location.

A method, a computer program product, and a computer system provide medications to a patient with a time gap. The method includes determining a dissolving pattern for the patient. The dissolving pattern includes a medication dissolving rate for a first medication prescribed to the patient and a filler dissolving rate for a filler selected so that the time gap is elapsed prior to a second medication being provided after the first medication. The medication dissolving rate and the filler dissolving rate are specific to the patient. The method includes determining dimensions of the first medication to correspond to a dosage of the prescribed first medication and dimensions of the filler to correspond to the time gap. The method includes providing a pill including at least the first medication and the filler, the first medication surrounding the filler such that the first medication is dissolved prior to the filler being dissolved.

A medical temperature monitoring system includes an electrical wire set having a thermistor at a distal end of the wire set configured to sense temperatures to which the thermistor is exposed; an electronic circuit in electrical communication with the wire set and the thermistor and configured to convert the temperatures sensed by the thermistor to temperature display signals; a display in electrical communication with the electronic circuit for receiving the temperature display signals and displaying temperatures corresponding to the temperature display signals; and a bead of cured protective material encapsulating the thermistor. The protective material is a radiation curable adhesive applied to the thermistor in an uncured state and then cured to encapsulate the thermistor. The bead of cured protective material electrically isolates the conductor sufficient to pass a Hi-Pot test at 500 VAC, <0.1 mA.

The present application provides a trypsin detection film, a preparation method therefor, application thereof and a trypsin detection kit, which relates to the technical field of trypsin detection. The preparation method for the trypsin detection film comprises the following steps: providing a polymer film substrate; immersing the polymer film substrate in a dye solution to attach a dye to the polymer film substrate, so as to obtain a trypsin detection film.

A swallowable capsule for obtaining fluid samples from the gastrointestinal (GI) tract of a subject. The capsule comprises an outer shell having an inlet port that allows a fluid sample to enter into the interior space of the capsule. A piston is arranged in the interior space and can be moved via a pressure generating device to exert pressure on one side of the piston to propel the piston from an open position, in which fluid can enter the capsule from outside to a closed position, in which entrance of fluid from outside the capsule is prevented. The piston has at least one seal portion that closes the shell opening in the closed position. A control unit is configured to control the pressure generating device so as to move the piston in a forward direction from the open position to the closed position.