A battery-operated electronic device, such as, e.g., a continuous glucose monitoring (CGM) transmitter, has a switch disconnect circuit that reduces battery discharge while the device is stored and/or in “shelf mode.” The device has two externally-accessible activation pads each configured to contact a same electrical conductor positioned in packaging for the device that causes the switch disconnect circuit to disconnect the battery from device electronics while the device is in the packaging. Upon removal of the device from the packaging, the two activation pads no longer contact the electrical conductor, causing the switch disconnect circuit to automatically connect the battery to the device electronics. Methods of reducing battery discharge in a battery-operated electronic device and other aspects are also described.

A system includes a sensor applicator, a sensor control device arranged within the sensor applicator and including an electronics housing and a sensor extending from a bottom of the electronics housing, and a cap coupled to one of the sensor applicator and the sensor control device, wherein the cap is removable prior to deploying the sensor control device from the sensor applicator.

Devices associated with on-body analyte sensor units are disclosed. These devices include any of packaging and/or loading systems, applicators and elements of the on-body sensor units themselves. Also, various approaches to connecting electrochemical analyte sensors to and/or within associated on-body analyte sensor units are disclosed. The connector approaches variously involve the use of unique sensor and ancillary element arrangements to facilitate assembly of separate electronics assemblies and sensor elements that are kept apart until the end user brings them together.

An assembly and method for delivery of an analyte sensor including a reusable applicator having a proximal portion and a distal portion are disclosed. The reusable applicator can include a housing, a sensor carrier configured a sensor carrier configured to releasably receive a first analyte sensor, a sharp carrier configured to releasably receive a sharp module and movable between the proximal portion of the reusable applicator and the distal portion of the reusable applicator for delivery of the first analyte sensor from the reusable applicator, and a reset tool configured to reset the reusable applicator for delivery of another analyte sensor.

The present invention discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting the sensor and containing a part of the sensor, a waterproof seal disposed above the implantation hole, and an elastic divider disposed in the implantation hole to separate the implantation hole and covering all over a cross-sectional area of the implantation hole.

A charging device for a physiological signal transmitter is disclosed, wherein the physiological signal transmitter is to receive and transmit a physiological signal from a subcutaneous tissue of a living body, and has a first electrical connecting port. The charging device comprises a body including a placing portion, a charging module and an operating module. The placing portion disposes thereon the physiological signal transmitter, and includes a bearing surface and a first opening. The bearing surface disposes thereon the physiological signal transmitter, and the first opening aligns therewith the first electrical connecting port of the physiological signal transmitter. The charging module is accommodated in the body and includes a second electrical connecting port, a third electrical connecting port and a circuit assembly. The second electrical connecting port is disposed in the opening and protrusive beyond or beneath the bearing surface. The third electrical connecting port is connected to a power source. The circuit assembly is configured to control a charging on the physiological signal transmitter, and electrically connected to the second electrical connecting port and the third electrical connecting port. The operating module is accommodated in the body, and coupled with the charging module, wherein when the physiological signal transmitter is placed on the bearing surface and in a first operating state, the operating module protrudes the second electrical connecting port beyond the bearing surface to electrically connect with the first electrical connecting port.

A sensor component is sterilised for use in a system for measuring the concentration of one or more analytes in fluid in a fluid line. The sensor component comprises one or more sensing elements having an optical property that varies with the concentration of the one or more analytes in the fluid, and is configured to engage with the fluid line such that the sensing elements are exposed to the fluid. The method comprises introducing a gaseous sterilising agent into a sealed cavity via one or more ports providing fluid connection to the cavity, wherein the one or more sensing elements are exposed to the cavity, replacing the gaseous sterilising agent with a sterile liquid via the ports, and sealing the ports. Also disclosed is a sensor component with a configuration facilitating the application of the method.

The present invention provides methods, compositions, kits, and devices for detecting heavy metals in dried blood (e.g., dried blood spots). For example, the present invention provides: 1) dried blood spot paper that is detectably free of heavy metals and methods of preparing such paper using organic acid; 2) dried blood extraction solutions optimized for heavy metal detection (e.g., extraction solutions containing acetic acid and/or gold); 3) methods for estimating venous blood volume from dried blood mass; and 4) kits and kit components optimized for heavy metal detection in dried blood (e.g., kits with paper detectably free of heavy metals, heavy metal free skin wipes, metal free collection case, etc.).

A medical device for detecting, at least one analyte, in a body fluid is disclosed. The medical device comprises: at least one analyte sensor having an insertable portion adapted for at least partially being inserted into a body tissue of a user, at least one insertion cannula, wherein the analyte sensor at least partially is placed inside the insertion cannula; at least one housing, wherein the housing comprises at least one sensor compartment, wherein the sensor compartment forms a sealed compartment receiving at least the insertable portion of the analyte sensor, wherein the sealed compartment comprises at least one detachable upper cap and at least one detachable lower cap, wherein the detachable lower cap is configured for detachment before insertion, thereby opening the insertable portion for insertion, wherein the insertion cannula is attached to the detachable upper cap, wherein the detachable upper cap is configured for detachment after insertion, thereby removing the insertion cannula; and at least one electronics unit, wherein the analyte sensor is operably connected to the electronics unit, wherein the electronics unit comprises at least one interconnect device with at least, one electronic component attached thereto, wherein the interconnect device fully or partially surrounds the housing.

A medical device for detecting at least one analyte in a body fluid, a method for assembling the medical device and a method of using the medical device are disclosed. The medical device comprises: an analyte sensor having an insertable portion; an insertion cannula receiving the insertable portion of the analyte sensor; an electronics unit connected with the analyte sensor; and a housing comprising an electronics compartment receiving the electronics unit and a sensor compartment receiving the analyte sensor, the sensor compartment forming a sealed compartment receiving the insertable portion of the analyte sensor, the sealed compartment comprising detachable upper and lower caps, the lower cap configured for detachment before insertion, the insertion cannula being attached to the upper cap, wherein detaching the upper cap after insertion removes the insertion cannula, wherein the electronics compartment at least partially surrounds the sensor compartment.