Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

A product allows gaseous manufacturing by-products to be vented from the inside a sealed package tray. An exemplary method for packaging a device includes sealing the device inside a package tray with a gas-permeable sealing material, resulting in a sealed package tray. The sealing material allows volatile substances to vent from inside the sealed package tray to outside the sealed package tray.

Devices, systems and methods are described herein that enable and make assessments related to pregnancy, including assessments related to a labor-related status such as the onset of true labor. In some embodiments, a pregnancy monitoring system comprises a portable, noninvasive data acquisition device adhered to a patient's skin, comprising at least two electrodes to measure uterine electrical activity, signal processing means, data storage means, and a battery. Systems for notification of the labor-related status are described.

The present invention is a holding case for an instrumented intra-oral appliance containing recorded data, which charges the intra-oral appliance while not in use and transmits recorded data to storage for review and analysis. The transferred data may be subjected to downloading, validation, storage, analysis, measuring, database fusion (with for example data from other devices), data output, and data recording. Output may be further transferred to a computer, processor, phone, tablet computer, or other hardware for review by a user or technical, research, medical, or other oversight personnel. The holding case can also send data to the appliance including firmware or other onboard operating instructions. The holding case can include additional features such as custom dentition of the user, UV light, or a visual user interface.

An implantable device for sensing data includes a subcutaneous sensor configured to couple with an implant. The implantable device is operably configured to wirelessly and transcutaneously transmit data sensed by the subcutaneous sensor. The sensor may be powered wirelessly and transcutaneously. Transmission of data and/or power may be provided by ultrasound sound waves. The sensor may be in electrical communication with a piezoelectric transducer configured to receive the ultrasound sound waves.

A system includes a sensor applicator, a sensor control device arranged within the sensor applicator and including an electronics housing and a sensor extending from a bottom of the electronics housing, and a cap coupled to one of the sensor applicator and the sensor control device, wherein the cap is removable prior to deploying the sensor control device from the sensor applicator.

A system includes a sensor applicator, a sensor control device arranged within the sensor applicator and including an electronics housing and a sensor extending from a bottom of the electronics housing, and a cap coupled to one of the sensor applicator and the sensor control device, wherein the cap is removable prior to deploying the sensor control device from the sensor applicator.

The present disclosure relates to a sterilization packaging method for a body-attachable biometric monitoring device. Provided is a sterilization packaging method for a body-attachable biometric monitoring device, the method in which a sterilization packaging process can be performed in a convenient and simple manner, further contamination which can occur during a sterilization process is prevented, damages due to moisture and the like after the packaging is complete are also prevented and thus complete sterilization packaging can be performed, in order to separately perform a sterilization packaging step in two steps, primary packaging is performed for a sterilizable state and then sterilization is performed, secondary packaging is performed to maintain airtightness for a primary packaged article which has been sterilized and thus penetration by an external contaminant and the like during the sterilization and packaging processes is prevented to prevent damages to a biometric monitoring device, a separate adsorbent is positioned outside the primary packaged article and then the secondary packaging is performed and thus functional degradation of the adsorbent during the sterilization process is prevented to enable inner packaging of the adsorbent in an excellent functional state, and a moisture removal function can be performed stably to enable a complete sterilization packaging.

Methods for treating tissue are provided. In one embodiment, an adjunct material, when secured to tissue, can receive at least one physiological element released from the tissue during healing progression of the tissue, and can exhibit first and second stiffnesses in compression that are approximately constant during first and second time periods from contact with the tissue, with the second stiffness decreasing with time as a function of at least one of oxidation, enzyme-catalyzed hydrolysis, and change of pH resulting from interaction with the at least one physiological element. In another embodiment, the adjunct can receive a unit volume of fluid that causes first and second portions of the adjunct to expand according to first and second expansion behaviors that differ from one another to apply different pressures to the tissue.

A charging device for a physiological signal transmitter is disclosed. The charging device includes a transmitter placing seat, and a controlling module controlling an operation between the charging device and the physiological signal transmitter in a safe state. When the physiological signal transmitter is at the predetermined position, the locking portion unlocks the operating portion to perform one of driving the second electrical connecting port to move from the first position to the second position to electrically connect to the first electrical connecting port and driving the second electrical connecting port to move from the second position to the first position to electrically disconnect to the first electrical connecting port.