Methods and systems for identifying optimized ablation targets for treating and preventing arrhythmias sustained by reentrant circuits are described. The methods comprise receiving at least one mesh generated from one or more images of a patient’s heart, receiving activation data generated from one or more simulations of electrical-signal propagation over the at least one mesh, generating at least one flow graph based on the activation data and the at least one mesh, and applying a max-flow min-cut algorithm to the at least one flow graph to determine at least one of a number, one or more dimensions, and one or more locations of one or more ablation targets. Non-transitory computer-readable media storing a set of instructions for treating and preventing arrhythmias sustained by reentrant circuits are also described.

A method is provided for cardiac pacing therapy guidance including: receiving an 3D or anatomic model and/or processing thereof, receiving location information of at least one heart conduction feature and/or processing thereof, receiving location information of at least one cardiac vein and/or processing thereof, receiving ECG recording data and/or processing thereof, determining a heart activation map relative to the model, and determining potential implant areas for implantation of at least one pacing system lead, such as for the purpose of outputting such information relating to the model and the potential implant areas for displaying thereof.

A noninvasive system for imaging, planning, and treating cardiac arrhythmia in a subject includes a noninvasive means for imaging a heart and identifying an arrhythmia including an array of body surface electrodes for noninvasively measuring electrical potentials at a plurality of locations to identify the arrhythmia, and a geometry determining device for noninvasively obtaining a heart-torso geometry. An imaging processor computes heart electrical activity data and generates an image of the heart from the electrical potentials and the heart-torso geometry. A treatment planning system for developing a noninvasive treatment plan for the arrhythmia is configured to import an arrhythmia target defined relative to the image of the heart, and register the imported arrhythmia target to a primary planning dataset. A noninvasive means for treating the arrhythmia includes implementing the noninvasive treatment plan developed by the treatment planning system.

An adaptive real-time radial k-space sampling trajectory (ARKS) can respond to a physiologic feedback signal to reduce motion effects and ensure sampling uniformity. In this adaptive k-space sampling strategy, the most recent signals from an ECG waveform can be continuously matched to the previous signal history, new radial k-space locations c were determined, and these MR signals combined using multi-shot or single-shot radial acquisition schemes. The disclosed methods allow for improved

A method includes receiving a first representation of an internal surface of at least a portion of a wall of an organ of a patient, and a second representation of an external surface of at least the portion of the wall of the organ. The first and second representations are registered with one another. An exploded representation is generated from the first and second representations, that shows both the internal surface and the external surface. The exploded representation is presented to a user.

The invention relates to a method for generating MR images (10, 20) of an object in its environment within a region of interest, said object executing motion comprising a plurality of moving phases within a period of time. According to several aspects of the invention, the method comprises the steps of: —providing a first dataset pertaining to one of the moving phases of the object (Si); —generating a first image (10) of a region of interest from the first dataset (S2); —identifying a dynamic region (12) and a static region (14) inside the first image (10), wherein the regions (12, 14) are predominantly dynamic or static respectively within the periodeperiod of time (S3); —editing the first image (10) by masking out the dynamic region (14) (S4); —performing an inverse Fourier transformation of the edited first image (16) showing the remaining static region (14) (S5); —providing a second dataset pertaining to one of the moving phases of the object (S6); —subtraction of the inverse Fourier transformation of the edited first image (16) with the remaining static region (14) from the second dataset (S7); —performing a Fourier transformation on the subtracted second dataset (18) (S8); and —generating a second image (20) of a reduced region of interest with respect to the region of interest of the first image (10), which reduced region of interest includes the dynamic region (12) (S9). The invention further relates to a corresponding MRI system for generating MR images of an object in its environment within a region of interest.

Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.

Systems and methods for producing ultrasound images are disclosed herein. In one embodiment, ultrasound image data are acquired in discrete time increments at one or more positions relative to a subject. Control points are added by a user for two or more image frames and a processor interpolates the location of the control points for image frames obtained at in-between times.

An image registration device includes: an image acquisition unit that acquires a plurality of images; a divided region setting unit that sets divided regions by dividing each registration processing target of the plurality of images; a pixel value conversion method determination unit that determines, for each set of divided regions set at the same position of the respective registration processing targets, a pixel value conversion method for each divided region based on a pixel value of each divided region of the set; a pixel value conversion unit that performs pixel value conversion within each divided region of the set of divided regions using the determined pixel value conversion method for each divided region; and a registration processing unit that performs registration processing on the plurality of images subjected to pixel value conversion.

A novel catheter-based system which ligates the left atrial appendage (LAA) on the outside of the heart, preferably using a combination of catheters and/or instruments, e.g., a guide catheter positioned inside the left atrial appendage which may assist in locating the left atrial appendage and/or assist in the optimal placement of a ligature on the outside of the appendage, and a ligating catheter and/or instrument outside the heart in the pericardial space to set a ligating element at the neck of the left atrial appendage.